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• W2011384425 abstract "A series of 2-substituted C-aryl glucosides have been synthesized and evaluated for inhibition of hSGLT1 and hSGLT2. Introduction of an appropriate ortho substituent at the proximal phenyl ring adjacent to the glycosidic bond was found to improve SGLT2 inhibitory activity and dramatically increase selectivity for hSGLT2 over hSGLT1. Selected compounds were investigated for in vivo efficacy." @default.
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• W2011384425 date "2010-06-15" @default.
• W2011384425 modified "2023-10-14" @default.
• W2011384425 title "ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors" @default.
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• W2011384425 doi "https://doi.org/10.1016/j.bmc.2010.04.088" @default.
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