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• W2011395400 abstract "We have previously demonstrated that differences in neuropathic pain-like behaviors after sciatic nerve injury genetically maps to the major histocompatibility complex (MHC) in rats carrying RT1c or RT1av1 haplotypes on the Piebald Virol Glaxo (PVG) background. In order to further explore the genetic contribution to neuropathic pain, we have here examined the MHC-congenic rat strains PVG-RT1n and PVG-RT1av1 and the inbred strains PVG (RT1c) and Brown-Norway (BN; RT1n). All studied strains developed mechanical hypersensitivity (allodynia-like behavior) of the hind paw after photochemically induced sciatic nerve injury. However, the PVG-RT1n and PVG strains displayed significantly more allodynia than PVG-RT1av1 and BN rats. In addition, the BN strain demonstrated an elevated threshold for the baseline response. The results demonstrate that both MHC and non-MHC genes influence experimental neuropathic pain in rats and also suggest that allelic variation contained in the RT1av1 haplotype on the PVG background protects against neuropathic pain." @default.
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• W2011395400 date "2008-09-01" @default.
• W2011395400 modified "2023-10-01" @default.
• W2011395400 title "Both MHC and non-MHC genes regulate development of experimental neuropathic pain in rats" @default.
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• W2011395400 doi "https://doi.org/10.1016/j.neulet.2008.07.027" @default.
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