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- W2011415785 abstract "Objective: This prospective randomized double-masked placebo controlled trial was designed to investigate if the use of vasopressin during abdominal hysterectomy would decrease blood loss.Methods: Fifty-one patients undergoing abdominal hysterectomy with the diagnosis of leiomyomatous uterus were randomized and received either vasopressin 10 U/10 mL of normal saline or 10 mL of normal saline, injected 5 mL bilaterally, 1 cm medial to the uterine vessels into the lower uterine segment. The sample size was determined assuming a one third reduction in total blood loss would be clinically relevant. A power analysis determined that 25 patients would be required in each group to assure a power of 0.80, at the 0.05 significance level.Results: Overall, the two groups were very similar with regard to their demographics, preoperative diagnosis, and relevant findings at the time of surgery. The mean total blood loss in the vasopressin and placebo groups was 445.41 mL and 748.42 mL respectively. Total blood loss was significantly decreased by 40% in the vasopressin group compared with the placebo group (P<.001). There was no statistically significant difference between the two groups with respect to possible confounding variables or surgical complications.Conclusion: The injection of vasopressin into the uterus at the time of abdominal hysterectomy significantly reduces blood loss without increasing morbidity. We have shown that it is a useful adjunct during abdominal hysterectomy." @default.
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- W2011415785 date "2001-05-01" @default.
- W2011415785 modified "2023-09-23" @default.
- W2011415785 title "Use of vasopressin during abdominal hysterectomy: a randomized control study" @default.
- W2011415785 doi "https://doi.org/10.1016/s0029-7844(01)01148-6" @default.
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