Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011429550> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2011429550 endingPage "5" @default.
- W2011429550 startingPage "1" @default.
- W2011429550 abstract "The anticancer drugs screening program is a long and expensive process. It is estimated that only 5% of drugs entering clinical trials are approved by the FDA. Moreover, many of the drugs that enter clinical trials are often of limited use in clinical practice, and most cancers remain untreatable. Brain tumors are particularly difficult to treat due to the presence of the blood brain barrier that limits the penetration of anticancer drugs. Additionally the isolation from most brain tumors of putative cancer stem cells and novel models of cancer stem cell biology suggest that anticancer drugs should be delivered for prolonged time and at higher concentrations to deplete any potential tumorigenic cell. In this paper, current concepts of cancer stem cell biology and novel concepts of anticancer drugs screening are integrated to develop a seven-steps algorithm as a guideline for the preclinical evaluation of active compounds for the treatment of brain tumors. The flexibility of the algorithm allows the inclusion of alternative studies to exhaustively investigate anticancer drugs and creates multiple opportunities where decisions to engage or not in early clinical trials can be made providing a useful tool for translational research in neurooncology." @default.
- W2011429550 created "2016-06-24" @default.
- W2011429550 creator A5075596477 @default.
- W2011429550 date "2012-07-03" @default.
- W2011429550 modified "2023-10-03" @default.
- W2011429550 title "An Algorithm for the Preclinical Screening of Anticancer Drugs Effective against Brain Tumors" @default.
- W2011429550 cites W1892378886 @default.
- W2011429550 cites W1966022935 @default.
- W2011429550 cites W1971624714 @default.
- W2011429550 cites W1976172485 @default.
- W2011429550 cites W1978623042 @default.
- W2011429550 cites W1985156459 @default.
- W2011429550 cites W1996963479 @default.
- W2011429550 cites W1999526725 @default.
- W2011429550 cites W2001576834 @default.
- W2011429550 cites W2010317454 @default.
- W2011429550 cites W2025724408 @default.
- W2011429550 cites W2035508211 @default.
- W2011429550 cites W2038644375 @default.
- W2011429550 cites W2044872298 @default.
- W2011429550 cites W2061041791 @default.
- W2011429550 cites W2064110215 @default.
- W2011429550 cites W2075889966 @default.
- W2011429550 cites W2079022594 @default.
- W2011429550 cites W2093917973 @default.
- W2011429550 cites W2100302700 @default.
- W2011429550 cites W2104505549 @default.
- W2011429550 cites W2105540740 @default.
- W2011429550 cites W2117889034 @default.
- W2011429550 cites W2140095545 @default.
- W2011429550 cites W2147960486 @default.
- W2011429550 cites W2153745983 @default.
- W2011429550 cites W2160382843 @default.
- W2011429550 cites W2161983416 @default.
- W2011429550 cites W2168053415 @default.
- W2011429550 cites W4255723385 @default.
- W2011429550 doi "https://doi.org/10.5402/2012/513580" @default.
- W2011429550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398605" @default.
- W2011429550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22830045" @default.
- W2011429550 hasPublicationYear "2012" @default.
- W2011429550 type Work @default.
- W2011429550 sameAs 2011429550 @default.
- W2011429550 citedByCount "4" @default.
- W2011429550 countsByYear W20114295502014 @default.
- W2011429550 countsByYear W20114295502015 @default.
- W2011429550 countsByYear W20114295502018 @default.
- W2011429550 countsByYear W20114295502022 @default.
- W2011429550 crossrefType "journal-article" @default.
- W2011429550 hasAuthorship W2011429550A5075596477 @default.
- W2011429550 hasBestOaLocation W20114295501 @default.
- W2011429550 hasConcept C121608353 @default.
- W2011429550 hasConcept C126322002 @default.
- W2011429550 hasConcept C142724271 @default.
- W2011429550 hasConcept C2779130545 @default.
- W2011429550 hasConcept C535046627 @default.
- W2011429550 hasConcept C60644358 @default.
- W2011429550 hasConcept C71924100 @default.
- W2011429550 hasConcept C86803240 @default.
- W2011429550 hasConcept C98274493 @default.
- W2011429550 hasConceptScore W2011429550C121608353 @default.
- W2011429550 hasConceptScore W2011429550C126322002 @default.
- W2011429550 hasConceptScore W2011429550C142724271 @default.
- W2011429550 hasConceptScore W2011429550C2779130545 @default.
- W2011429550 hasConceptScore W2011429550C535046627 @default.
- W2011429550 hasConceptScore W2011429550C60644358 @default.
- W2011429550 hasConceptScore W2011429550C71924100 @default.
- W2011429550 hasConceptScore W2011429550C86803240 @default.
- W2011429550 hasConceptScore W2011429550C98274493 @default.
- W2011429550 hasLocation W20114295501 @default.
- W2011429550 hasLocation W20114295502 @default.
- W2011429550 hasLocation W20114295503 @default.
- W2011429550 hasLocation W20114295504 @default.
- W2011429550 hasOpenAccess W2011429550 @default.
- W2011429550 hasPrimaryLocation W20114295501 @default.
- W2011429550 hasRelatedWork W2003879170 @default.
- W2011429550 hasRelatedWork W2365364931 @default.
- W2011429550 hasRelatedWork W2385157319 @default.
- W2011429550 hasRelatedWork W2418638721 @default.
- W2011429550 hasRelatedWork W2767460948 @default.
- W2011429550 hasRelatedWork W2767729055 @default.
- W2011429550 hasRelatedWork W2954861808 @default.
- W2011429550 hasRelatedWork W3206348618 @default.
- W2011429550 hasRelatedWork W4226370902 @default.
- W2011429550 hasRelatedWork W4248189593 @default.
- W2011429550 hasVolume "2012" @default.
- W2011429550 isParatext "false" @default.
- W2011429550 isRetracted "false" @default.
- W2011429550 magId "2011429550" @default.
- W2011429550 workType "article" @default.