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- W2011431839 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably during evolution and is widely expressed in the mammalian brain. In Drosophila , mutation of the PACAP homologue results in behavioral defects, including impaired olfaction-associated learning and changes in ethanol sensitivity. Here, we report the generation of mice lacking the PACAP gene (PACAP −/− ). PACAP −/− mice were born in the expected Mendelian ratios but had a high early-mortality rate. The surviving adult PACAP −/− mice displayed remarkable behavioral changes; they exhibited hyperactive and explosive jumping behaviors in an open field, increased exploratory behavior, and less anxiety in the elevated plus maze, emergence, and novel-object tests. Analysis of PACAP −/− mice brains revealed that the serotonin metabolite 5-hydroxyindoleacetic acid was slightly decreased in the cortex and striatum compared with wild-type mice. The present study provides evidence that PACAP plays a previously uncharacterized role in the regulation of psychomotor behaviors." @default.
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- W2011431839 date "2001-10-30" @default.
- W2011431839 modified "2023-10-17" @default.
- W2011431839 title "Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)" @default.
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- W2011431839 doi "https://doi.org/10.1073/pnas.231094498" @default.
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