Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011436438> ?p ?o ?g. }
- W2011436438 endingPage "2019" @default.
- W2011436438 startingPage "2008" @default.
- W2011436438 abstract "Acetylcholine profoundly affects neocortical function, being involved in arousal, attention, learning, memory, sensory and motor function, and plasticity. The majority of cholinergic afferents to neocortex are from neurons in nucleus basalis. Nucleus basalis also contains projecting neurons that release other transmitters, including GABA and possibly glutamate. Hence, electrical stimulation of nucleus basalis evokes the release of a mixture of neurotransmitters in neocortex, and this lack of selectivity has impeded research on cholinergic signaling in neocortex. We describe a method for the selective stimulation of cholinergic axons in neocortex. We used the Cre-lox system and a viral vector to express the light-activated protein channelrhodopsin-2 in cholinergic neurons in nucleus basalis and their axons in neocortex. Labeled neurons depolarized on illumination with blue light but were otherwise unchanged. In anesthetized mice, illumination of neocortex desynchronized the local field potential, indicating that light evoked release of ACh. This novel technique will enable many new studies of the cellular, network, and behavioral physiology of ACh in neocortex." @default.
- W2011436438 created "2016-06-24" @default.
- W2011436438 creator A5023370607 @default.
- W2011436438 creator A5047206221 @default.
- W2011436438 creator A5079772086 @default.
- W2011436438 date "2012-04-01" @default.
- W2011436438 modified "2023-09-30" @default.
- W2011436438 title "Selective optogenetic stimulation of cholinergic axons in neocortex" @default.
- W2011436438 cites W138934867 @default.
- W2011436438 cites W1587009451 @default.
- W2011436438 cites W1852715831 @default.
- W2011436438 cites W1906725220 @default.
- W2011436438 cites W1932235786 @default.
- W2011436438 cites W1966698116 @default.
- W2011436438 cites W1967411907 @default.
- W2011436438 cites W1969045806 @default.
- W2011436438 cites W1976485053 @default.
- W2011436438 cites W1980737345 @default.
- W2011436438 cites W1987332330 @default.
- W2011436438 cites W1987964421 @default.
- W2011436438 cites W1988852098 @default.
- W2011436438 cites W1990748097 @default.
- W2011436438 cites W1991444801 @default.
- W2011436438 cites W1997205438 @default.
- W2011436438 cites W1997210267 @default.
- W2011436438 cites W1997470921 @default.
- W2011436438 cites W2000421906 @default.
- W2011436438 cites W2005114592 @default.
- W2011436438 cites W2010645840 @default.
- W2011436438 cites W2010975466 @default.
- W2011436438 cites W2014630817 @default.
- W2011436438 cites W2023708889 @default.
- W2011436438 cites W2028311911 @default.
- W2011436438 cites W2032924239 @default.
- W2011436438 cites W2036744364 @default.
- W2011436438 cites W2036962817 @default.
- W2011436438 cites W2037820041 @default.
- W2011436438 cites W2047347093 @default.
- W2011436438 cites W2050586239 @default.
- W2011436438 cites W2050932531 @default.
- W2011436438 cites W2056210890 @default.
- W2011436438 cites W2057178098 @default.
- W2011436438 cites W2058445457 @default.
- W2011436438 cites W2067463771 @default.
- W2011436438 cites W2074663969 @default.
- W2011436438 cites W2077847569 @default.
- W2011436438 cites W2079373480 @default.
- W2011436438 cites W2086854067 @default.
- W2011436438 cites W2087128420 @default.
- W2011436438 cites W2088944569 @default.
- W2011436438 cites W2093545276 @default.
- W2011436438 cites W2102733342 @default.
- W2011436438 cites W2117506145 @default.
- W2011436438 cites W2127183925 @default.
- W2011436438 cites W2143152453 @default.
- W2011436438 cites W2151380506 @default.
- W2011436438 cites W2155265451 @default.
- W2011436438 cites W2155821975 @default.
- W2011436438 cites W2159423248 @default.
- W2011436438 cites W2160961804 @default.
- W2011436438 cites W2162056177 @default.
- W2011436438 cites W2163438163 @default.
- W2011436438 cites W2168415226 @default.
- W2011436438 cites W2396331417 @default.
- W2011436438 cites W2414042622 @default.
- W2011436438 cites W2419563370 @default.
- W2011436438 cites W83614152 @default.
- W2011436438 doi "https://doi.org/10.1152/jn.00870.2011" @default.
- W2011436438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3331667" @default.
- W2011436438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22236708" @default.
- W2011436438 hasPublicationYear "2012" @default.
- W2011436438 type Work @default.
- W2011436438 sameAs 2011436438 @default.
- W2011436438 citedByCount "87" @default.
- W2011436438 countsByYear W20114364382013 @default.
- W2011436438 countsByYear W20114364382014 @default.
- W2011436438 countsByYear W20114364382015 @default.
- W2011436438 countsByYear W20114364382016 @default.
- W2011436438 countsByYear W20114364382017 @default.
- W2011436438 countsByYear W20114364382018 @default.
- W2011436438 countsByYear W20114364382019 @default.
- W2011436438 countsByYear W20114364382020 @default.
- W2011436438 countsByYear W20114364382021 @default.
- W2011436438 countsByYear W20114364382022 @default.
- W2011436438 countsByYear W20114364382023 @default.
- W2011436438 crossrefType "journal-article" @default.
- W2011436438 hasAuthorship W2011436438A5023370607 @default.
- W2011436438 hasAuthorship W2011436438A5047206221 @default.
- W2011436438 hasAuthorship W2011436438A5079772086 @default.
- W2011436438 hasBestOaLocation W20114364382 @default.
- W2011436438 hasConcept C104966671 @default.
- W2011436438 hasConcept C134018914 @default.
- W2011436438 hasConcept C169760540 @default.
- W2011436438 hasConcept C22885893 @default.
- W2011436438 hasConcept C24998067 @default.
- W2011436438 hasConcept C2775910092 @default.
- W2011436438 hasConcept C2777222312 @default.
- W2011436438 hasConcept C2778205193 @default.