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- W2011446219 abstract "A recent study conducted at Royal Free and University College London Medical School, UK has identified a specific allele of the APO-E gene that significantly elevates the risk of heart disease in smokers. Led by Professor Steve Humphries, the research team monitored the health of >3000 middle-aged men over a period of 8 years. They discovered that smokers carrying the E4 form of the gene were 4-times more likely to develop cardiovascular problems than non-smokers. APO-E encodes apolipoprotein E – a protein critical in preventing oxidation of LDL cholesterol; the E4 version appears to be least effective in this role. Although up to a quarter of the UK male population carries the E4 allele, placing them at greater risk, Humphries does not advocate the development of a risk-assessing genetic test. Cessation of smoking remains the most effective method of risk reduction. PON" @default.
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- W2011446219 date "2001-09-01" @default.
- W2011446219 modified "2023-09-23" @default.
- W2011446219 title "Gene increases risks for smokers" @default.
- W2011446219 doi "https://doi.org/10.1016/s1471-4914(01)02147-5" @default.
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