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• W2011446445 abstract "Vitamin B6 (B6) deficiency affects homocysteine metabolism, and this leads to hyperhomocysteinemia. In this study, we examined i) the effects of B6-deficiency and graduated levels of dietary methionine on homocysteine metabolism, and ii) the effects of fortified folate on homocysteine metabolism. In experiment 1, Wistar male rats were fed a control or a B6-deficient diet supplemented with l-methionine at a level of 3, 6, or 9 g/kg of diet for 5 weeks. The resulting plasma homocysteine levels in the B6-deficient groups increased in relation to the increase in dietary methionine level. Next, in experiment 2, rats were fed a control, B6-deficient, or folate enriched (10 mg pteroylmonoglutamic acid/kg) B6-deficient diet containing l-methionine at 9 g/kg for 5 weeks. Although the B6-deficient diet induced hyperhomocysteinemia, folate fortification ameliorated the plasma homocysteine concentration. Overall, our results indicate that folate fortification ameliorates the hyperhomocysteinemia induced by B6 deficiency and supplemental methionine intake." @default.
• W2011446445 created "2016-06-24" @default.
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• W2011446445 date "2012-10-23" @default.
• W2011446445 modified "2023-10-03" @default.
• W2011446445 title "Folic Acid Fortification Ameliorates Hyperhomocysteinemia Caused by a Vitamin B₆-Deficient Diet Supplemented with<scp>L</scp>-Methionine" @default.
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• W2011446445 doi "https://doi.org/10.1271/bbb.120279" @default.
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