FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011451869> ?p ?o ?g. }

• W2011451869 endingPage "119" @default.
• W2011451869 startingPage "107" @default.
• W2011451869 abstract "In sea urchin embryos, the initial animal-vegetal (AV) axis is specified during oogenesis but the mechanism is largely unknown. By using chemical reagents such as lithium, it is possible to shift the principal embryonic territories toward a vegetal fate. We have investigated the possibility of obtaining the same morphological effect as with lithium by utilizing Fabs against the maternal Bep4 protein that is localized in the animal part of Paracentrotus lividus egg and embryos. Incubation of fertilized eggs with Fabs against Bep4 protein causes exogastrulation at 48 h of development of P. lividus embryos, similar to embryos treated with lithium. This vegetalizing effect was ascertained by utilizing territorial markers such as EctoV, EndoI, and Ig8. The effect of Fabs against Bep4 on gene expression was observed by monitoring spatial expression of the hatching enzyme gene. A decreased expression domain compared to its normal spatial distribution was detected and this effect was again comparable to those obtained with lithium treatment. Association of Bep4 with a cadherin was demonstrated by immunoprecipitation and immunostaining experiments, and an involvement in cell signaling is discussed. In addition, treatment of embryos with anti-Bep4 Fabs causes an enhancement in the level and an expansion in the pattern of nuclear beta-catenin. Moreover, this treatment also provokes a decrease of beta-catenin in adherens junctions. Together, these data indicate that anti-Bep4 Fabs provoke a shift of the animal-vegetal boundary toward the animal pole and suggest an active role of Bep4 protein in patterning along the AV axis." @default.
• W2011451869 created "2016-06-24" @default.
• W2011451869 creator A5026649366 @default.
• W2011451869 creator A5028335898 @default.
• W2011451869 creator A5038393978 @default.
• W2011451869 creator A5043909142 @default.
• W2011451869 date "2001-06-01" @default.
• W2011451869 modified "2023-09-26" @default.
• W2011451869 title "Bep4 Protein Is Involved in Patterning along the Animal–Vegetal Axis in the Paracentrotus lividus Embryo" @default.
• W2011451869 cites W1507992335 @default.
• W2011451869 cites W1910862521 @default.
• W2011451869 cites W1927894522 @default.
• W2011451869 cites W1963493954 @default.
• W2011451869 cites W1964266829 @default.
• W2011451869 cites W1965675804 @default.
• W2011451869 cites W1966664463 @default.
• W2011451869 cites W1967208634 @default.
• W2011451869 cites W1977229813 @default.
• W2011451869 cites W1992167522 @default.
• W2011451869 cites W2000015384 @default.
• W2011451869 cites W2002006586 @default.
• W2011451869 cites W2007215839 @default.
• W2011451869 cites W2012477673 @default.
• W2011451869 cites W2015158699 @default.
• W2011451869 cites W2027715295 @default.
• W2011451869 cites W2034301820 @default.
• W2011451869 cites W2039622517 @default.
• W2011451869 cites W2051788298 @default.
• W2011451869 cites W2061423346 @default.
• W2011451869 cites W2068050329 @default.
• W2011451869 cites W2071915231 @default.
• W2011451869 cites W2075719209 @default.
• W2011451869 cites W2077182969 @default.
• W2011451869 cites W2084457841 @default.
• W2011451869 cites W2084667467 @default.
• W2011451869 cites W2085968319 @default.
• W2011451869 cites W2089273867 @default.
• W2011451869 cites W2116428404 @default.
• W2011451869 cites W2116644216 @default.
• W2011451869 cites W2117799366 @default.
• W2011451869 cites W2118409394 @default.
• W2011451869 cites W2119847528 @default.
• W2011451869 cites W2127462980 @default.
• W2011451869 cites W2143214449 @default.
• W2011451869 cites W2144300167 @default.
• W2011451869 cites W2145193273 @default.
• W2011451869 cites W2155832999 @default.
• W2011451869 cites W2161840169 @default.
• W2011451869 cites W2166082074 @default.
• W2011451869 cites W2185263368 @default.
• W2011451869 cites W2186309647 @default.
• W2011451869 cites W2285915540 @default.
• W2011451869 cites W2432325459 @default.
• W2011451869 cites W2461291411 @default.
• W2011451869 cites W96091379 @default.
• W2011451869 doi "https://doi.org/10.1006/dbio.2001.0233" @default.
• W2011451869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11356023" @default.
• W2011451869 hasPublicationYear "2001" @default.
• W2011451869 type Work @default.
• W2011451869 sameAs 2011451869 @default.
• W2011451869 citedByCount "9" @default.
• W2011451869 countsByYear W20114518692013 @default.
• W2011451869 countsByYear W20114518692017 @default.
• W2011451869 crossrefType "journal-article" @default.
• W2011451869 hasAuthorship W2011451869A5026649366 @default.
• W2011451869 hasAuthorship W2011451869A5028335898 @default.
• W2011451869 hasAuthorship W2011451869A5038393978 @default.
• W2011451869 hasAuthorship W2011451869A5043909142 @default.
• W2011451869 hasBestOaLocation W20114518691 @default.
• W2011451869 hasConcept C105702510 @default.
• W2011451869 hasConcept C129536746 @default.
• W2011451869 hasConcept C1491633281 @default.
• W2011451869 hasConcept C149402561 @default.
• W2011451869 hasConcept C153911025 @default.
• W2011451869 hasConcept C194058213 @default.
• W2011451869 hasConcept C196843134 @default.
• W2011451869 hasConcept C201508349 @default.
• W2011451869 hasConcept C2776908312 @default.
• W2011451869 hasConcept C2779436081 @default.
• W2011451869 hasConcept C55493867 @default.
• W2011451869 hasConcept C6047887 @default.
• W2011451869 hasConcept C86803240 @default.
• W2011451869 hasConcept C87073359 @default.
• W2011451869 hasConcept C95444343 @default.
• W2011451869 hasConceptScore W2011451869C105702510 @default.
• W2011451869 hasConceptScore W2011451869C129536746 @default.
• W2011451869 hasConceptScore W2011451869C1491633281 @default.
• W2011451869 hasConceptScore W2011451869C149402561 @default.
• W2011451869 hasConceptScore W2011451869C153911025 @default.
• W2011451869 hasConceptScore W2011451869C194058213 @default.
• W2011451869 hasConceptScore W2011451869C196843134 @default.
• W2011451869 hasConceptScore W2011451869C201508349 @default.
• W2011451869 hasConceptScore W2011451869C2776908312 @default.
• W2011451869 hasConceptScore W2011451869C2779436081 @default.
• W2011451869 hasConceptScore W2011451869C55493867 @default.
• W2011451869 hasConceptScore W2011451869C6047887 @default.
• W2011451869 hasConceptScore W2011451869C86803240 @default.
• W2011451869 hasConceptScore W2011451869C87073359 @default.

• next