FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011452661> ?p ?o ?g. }

• W2011452661 endingPage "3362" @default.
• W2011452661 startingPage "3350" @default.
• W2011452661 abstract "Mutation-based treatments are a new development in genetic medicine, in which the nature of the mutation dictates the therapeutic strategy. Interest has recently focused on diseases caused by premature termination codons (PTCs). Drugs inducing the readthrough of these PTCs restore the production of a full-length protein. In this study, we explored the possibility of using aminoglycoside antibiotics to induce the production of a full-length functional p53 protein from a gene carrying a PTC. We identified a human cancer cell line containing a PTC, for which high levels of readthrough were obtained in the presence of aminoglycosides. Using these cells, we demonstrated that aminoglycoside treatment stabilized the mutant mRNA, which would otherwise have been degraded by non-sense-mediated decay, resulting in the production of a functional full-length p53 protein. Finally, we showed that aminoglycoside treatment decreased the viability of cancer cells specifically in the presence of nonsense-mutated p53 gene. These results open possibilities of developing promising treatments of cancers linked with non-sense mutations in tumor suppressor genes. They show that molecules designed to induce stop-codon readthrough can be used to inhibit tumor growth and offer a rational basis for developing new personalized strategies that could diversify the existing arsenal of cancer therapies." @default.
• W2011452661 created "2016-06-24" @default.
• W2011452661 creator A5028426279 @default.
• W2011452661 creator A5061404649 @default.
• W2011452661 creator A5074291311 @default.
• W2011452661 creator A5090435222 @default.
• W2011452661 date "2010-12-10" @default.
• W2011452661 modified "2023-10-16" @default.
• W2011452661 title "Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides" @default.
• W2011452661 cites W1971724293 @default.
• W2011452661 cites W1979319210 @default.
• W2011452661 cites W1987766109 @default.
• W2011452661 cites W1988269377 @default.
• W2011452661 cites W1988397255 @default.
• W2011452661 cites W1988494414 @default.
• W2011452661 cites W1988501412 @default.
• W2011452661 cites W1994734184 @default.
• W2011452661 cites W1996089239 @default.
• W2011452661 cites W2002573912 @default.
• W2011452661 cites W2004214625 @default.
• W2011452661 cites W2013330927 @default.
• W2011452661 cites W2014780970 @default.
• W2011452661 cites W2021258923 @default.
• W2011452661 cites W2022647537 @default.
• W2011452661 cites W2022944296 @default.
• W2011452661 cites W2028930203 @default.
• W2011452661 cites W2038527941 @default.
• W2011452661 cites W2041613899 @default.
• W2011452661 cites W2045410328 @default.
• W2011452661 cites W2046419821 @default.
• W2011452661 cites W2051011059 @default.
• W2011452661 cites W2060354975 @default.
• W2011452661 cites W2069289373 @default.
• W2011452661 cites W2074477570 @default.
• W2011452661 cites W2076732344 @default.
• W2011452661 cites W2081894694 @default.
• W2011452661 cites W2085811948 @default.
• W2011452661 cites W2092902276 @default.
• W2011452661 cites W2095273007 @default.
• W2011452661 cites W2105552492 @default.
• W2011452661 cites W2105735073 @default.
• W2011452661 cites W2107129827 @default.
• W2011452661 cites W2122967691 @default.
• W2011452661 cites W2123767456 @default.
• W2011452661 cites W2129905922 @default.
• W2011452661 cites W2131056651 @default.
• W2011452661 cites W2132264109 @default.
• W2011452661 cites W2141439233 @default.
• W2011452661 cites W2144347168 @default.
• W2011452661 cites W2146661675 @default.
• W2011452661 cites W2146970739 @default.
• W2011452661 cites W2151956271 @default.
• W2011452661 cites W2153172903 @default.
• W2011452661 cites W2155570392 @default.
• W2011452661 cites W2156299289 @default.
• W2011452661 cites W2157305393 @default.
• W2011452661 cites W2158010208 @default.
• W2011452661 cites W2158494985 @default.
• W2011452661 cites W2160400422 @default.
• W2011452661 cites W4211018016 @default.
• W2011452661 doi "https://doi.org/10.1093/nar/gkq1277" @default.
• W2011452661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3082906" @default.
• W2011452661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21149266" @default.
• W2011452661 hasPublicationYear "2010" @default.
• W2011452661 type Work @default.
• W2011452661 sameAs 2011452661 @default.
• W2011452661 citedByCount "119" @default.
• W2011452661 countsByYear W20114526612012 @default.
• W2011452661 countsByYear W20114526612013 @default.
• W2011452661 countsByYear W20114526612014 @default.
• W2011452661 countsByYear W20114526612015 @default.
• W2011452661 countsByYear W20114526612016 @default.
• W2011452661 countsByYear W20114526612017 @default.
• W2011452661 countsByYear W20114526612018 @default.
• W2011452661 countsByYear W20114526612019 @default.
• W2011452661 countsByYear W20114526612020 @default.
• W2011452661 countsByYear W20114526612021 @default.
• W2011452661 countsByYear W20114526612022 @default.
• W2011452661 countsByYear W20114526612023 @default.
• W2011452661 crossrefType "journal-article" @default.
• W2011452661 hasAuthorship W2011452661A5028426279 @default.
• W2011452661 hasAuthorship W2011452661A5061404649 @default.
• W2011452661 hasAuthorship W2011452661A5074291311 @default.
• W2011452661 hasAuthorship W2011452661A5090435222 @default.
• W2011452661 hasBestOaLocation W20114526611 @default.
• W2011452661 hasConcept C104317684 @default.
• W2011452661 hasConcept C119599485 @default.
• W2011452661 hasConcept C127413603 @default.
• W2011452661 hasConcept C143065580 @default.
• W2011452661 hasConcept C143141573 @default.
• W2011452661 hasConcept C179185449 @default.
• W2011452661 hasConcept C2777787772 @default.
• W2011452661 hasConcept C2778264664 @default.
• W2011452661 hasConcept C501593827 @default.
• W2011452661 hasConcept C501734568 @default.
• W2011452661 hasConcept C502942594 @default.
• W2011452661 hasConcept C54355233 @default.
• W2011452661 hasConcept C555283112 @default.

• next