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- W2011453521 abstract "Steroid hormone receptors are currently the key to selecting patients who might benefit from endocrine manipulation. As knowledge of the interaction between the various receptors in the cytoplasm and nucleus increases, it is hoped that the percentage of patients who might benefit by manipulation of those hormones will continue to increase. The presence of estrogen receptor coupled with progesterone receptor and a therapeutic test of endocrine sensitivity such as oophorectomy, response to antiestrogens, L-dopa, probably aminoglutethimide and a long tumor-free interval offers an effective way to screen those patients who are excellent candidates for additional endocrine ablation. In this retrospective review of 206 evaluable patients with metastatic breast cancer treated by endocrine ablation with adrenalectomy or hypophysectomy, objective responses were observed in only 50 percent of patients. Estrogen receptor analyses were performed in one or more breast cancer specimens in 113 patients. This study demonstrated that a patient who was estrogen receptor positive and responded to a functional test of endocrine sensitivity had a 70 to 80 percent chance of also benefiting from adrenalectomy or hypophysectomy. Conversely, patients with absent or unknown hormone receptors who fail therapeutic trials of endocrine sensitivity have little or no chance of responding to major ablation and are best treated with multiagent chemotherapy. The value of sequentially treating selected patients with endocrine manipulation as well as chemotherapy was also evident. Patients who did not respond to endocrine manipulation survived slightly over 2 years on chemotherapy. Patients who responded to major ablation lived with metastases an average of 4 years, whereas complete responders lived with metastatic disease an average of 6 years. These data reinforce our belief that a failure to choose and treat patients selectively by all modalities available significantly reduces useful survival in patients with metastatic breast cancer." @default.
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- W2011453521 date "1980-07-01" @default.
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- W2011453521 title "Endocrine ablation for metastatic breast cancer: A reappraisal of hormone receptors" @default.
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- W2011453521 doi "https://doi.org/10.1016/0002-9610(80)90435-3" @default.
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