FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011456844> ?p ?o ?g. }

• W2011456844 endingPage "1745" @default.
• W2011456844 startingPage "1739" @default.
• W2011456844 abstract "The present study investigated whether pregnancy and circulatory ovarian hormones increase the sensitivity of the mesenteric artery to calcitonin gene-related peptide (CGRP)-induced relaxation and possible mechanisms involved in this process. Mesenteric arteries from young adult male rats or female rats (during estrous cycle, after ovariectomy, at Day 20 of gestation, or Postpartum Day 2) were isolated, and the responsiveness of the vessels to CGRP was examined with a small vessel myograph. The CGRP (10−10 to 10−7 M) produced a concentration-dependent relaxation of norepinephrine-induced contractions in mesenteric arteries of all groups. Arterial relaxation sensitivity to CGRP was significantly (P < 0.05) greater in female rats compared with male rats. Pregnancy increased the sensitivity to CGRP significantly (P < 0.05) compared to ovariectomized and Postpartum Day 2 rats. In pregnant rats, CGRP-receptor antagonist, CGRP8–37, inhibited the relaxation responses produced by CGRP. The CGRP-induced relaxation was not affected by NG-nitro-l-arginine methyl ester (nitric oxide inhibitor, 10−4 M) but was significantly (P < 0.05) attenuated by an inhibitor of guanylate cyclase (1H-[1, 2, 4] oxadizaolo[4, 3 -a]quinoxalin-1-one, 10−5 M). Relaxation responses of CGRP on mesenteric arteries were blocked (P < 0.05) by a cAMP-dependent protein kinase A inhibitor, Rp-cAMPs (10−5 M). The CGRP-induced vasorelaxation was significantly (P < 0.05) attenuated by calcium-dependent (tetraethylammonium, 10−3 M), but not ATP-sensitive (glybenclamide, 10−5 M), potassium channel blocker. Therefore, the results of the present study suggest that mesenteric vascular sensitivity to CGRP is higher during pregnancy and that cAMP, cGMP, and calcium-dependent potassium channels appear to be involved. Therefore, we propose that CGRP-mediated vasodilation may be important to maintain vascular adaptations during pregnancy." @default.
• W2011456844 created "2016-06-24" @default.
• W2011456844 creator A5017665929 @default.
• W2011456844 creator A5035519424 @default.
• W2011456844 creator A5044248592 @default.
• W2011456844 creator A5046889331 @default.
• W2011456844 creator A5078033952 @default.
• W2011456844 date "2004-11-01" @default.
• W2011456844 modified "2023-10-14" @default.
• W2011456844 title "Mesenteric Arterial Relaxation to Calcitonin Gene-Related Peptide Is Increased During Pregnancy and by Sex Steroid Hormones1" @default.
• W2011456844 cites W1593442063 @default.
• W2011456844 cites W1964615624 @default.
• W2011456844 cites W1972444390 @default.
• W2011456844 cites W1975870506 @default.
• W2011456844 cites W1978906786 @default.
• W2011456844 cites W1979442189 @default.
• W2011456844 cites W1979492130 @default.
• W2011456844 cites W1980744095 @default.
• W2011456844 cites W1981235584 @default.
• W2011456844 cites W1984212352 @default.
• W2011456844 cites W1986647797 @default.
• W2011456844 cites W1990207368 @default.
• W2011456844 cites W1990456287 @default.
• W2011456844 cites W1991140195 @default.
• W2011456844 cites W1993606462 @default.
• W2011456844 cites W1999056699 @default.
• W2011456844 cites W2000098610 @default.
• W2011456844 cites W2004819411 @default.
• W2011456844 cites W2011800255 @default.
• W2011456844 cites W2017534721 @default.
• W2011456844 cites W2023255319 @default.
• W2011456844 cites W2024041373 @default.
• W2011456844 cites W2026940128 @default.
• W2011456844 cites W2029253166 @default.
• W2011456844 cites W2030411045 @default.
• W2011456844 cites W2030640146 @default.
• W2011456844 cites W2036874023 @default.
• W2011456844 cites W2042405468 @default.
• W2011456844 cites W2043024587 @default.
• W2011456844 cites W2045337129 @default.
• W2011456844 cites W2047838831 @default.
• W2011456844 cites W2052840333 @default.
• W2011456844 cites W2052897175 @default.
• W2011456844 cites W2053277833 @default.
• W2011456844 cites W2056629676 @default.
• W2011456844 cites W2062491158 @default.
• W2011456844 cites W2070824471 @default.
• W2011456844 cites W2081408299 @default.
• W2011456844 cites W2083271446 @default.
• W2011456844 cites W2086556573 @default.
• W2011456844 cites W2087427200 @default.
• W2011456844 cites W2091759202 @default.
• W2011456844 cites W2102261160 @default.
• W2011456844 cites W2104189404 @default.
• W2011456844 cites W2134615137 @default.
• W2011456844 cites W2137990309 @default.
• W2011456844 cites W2139878437 @default.
• W2011456844 cites W2142543494 @default.
• W2011456844 cites W2154529549 @default.
• W2011456844 cites W2165879301 @default.
• W2011456844 cites W2168418861 @default.
• W2011456844 cites W2171196215 @default.
• W2011456844 cites W35939948 @default.
• W2011456844 doi "https://doi.org/10.1095/biolreprod.104.031369" @default.
• W2011456844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15286037" @default.
• W2011456844 hasPublicationYear "2004" @default.
• W2011456844 type Work @default.
• W2011456844 sameAs 2011456844 @default.
• W2011456844 citedByCount "30" @default.
• W2011456844 countsByYear W20114568442012 @default.
• W2011456844 countsByYear W20114568442013 @default.
• W2011456844 countsByYear W20114568442014 @default.
• W2011456844 countsByYear W20114568442015 @default.
• W2011456844 countsByYear W20114568442016 @default.
• W2011456844 countsByYear W20114568442018 @default.
• W2011456844 countsByYear W20114568442021 @default.
• W2011456844 crossrefType "journal-article" @default.
• W2011456844 hasAuthorship W2011456844A5017665929 @default.
• W2011456844 hasAuthorship W2011456844A5035519424 @default.
• W2011456844 hasAuthorship W2011456844A5044248592 @default.
• W2011456844 hasAuthorship W2011456844A5046889331 @default.
• W2011456844 hasAuthorship W2011456844A5078033952 @default.
• W2011456844 hasBestOaLocation W20114568441 @default.
• W2011456844 hasConcept C118303440 @default.
• W2011456844 hasConcept C126322002 @default.
• W2011456844 hasConcept C134018914 @default.
• W2011456844 hasConcept C163170386 @default.
• W2011456844 hasConcept C170493617 @default.
• W2011456844 hasConcept C2776820930 @default.
• W2011456844 hasConcept C2779234561 @default.
• W2011456844 hasConcept C2779627488 @default.
• W2011456844 hasConcept C2780771799 @default.
• W2011456844 hasConcept C2781207646 @default.
• W2011456844 hasConcept C46973012 @default.
• W2011456844 hasConcept C54355233 @default.
• W2011456844 hasConcept C71924100 @default.
• W2011456844 hasConcept C86803240 @default.
• W2011456844 hasConceptScore W2011456844C118303440 @default.

• next