Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011467013> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2011467013 endingPage "733" @default.
- W2011467013 startingPage "728" @default.
- W2011467013 abstract "Antisense oligodeoxy-nucleoside phosphorothioates (OPTs) of L-myc were encapsulated into reconstituted influenza-virus-A envelopes (virosomes). The envelopes of the virosomes consisted of a single positively charged (cationic) lipid bilayer. Binding of cationic virosomes to cellular receptors that are membrane glycoproteins or glycolipids containing terminal sialic acid is mediated by the hemagglutinin glycoprotein (HA) of the influenza virus. After internalization through receptor-mediated endocytosis, cationic virosomes fuse efficiently with the membranes of the endosomal-cell compartment, and as a consequence the encapsulated OPT are delivered to the cell cytoplasma. Examination by fluorescence microscopy of the cellular uptake of cationic virosomes containing fluorescein-labeled OPT showed rapid and efficient incorporation of virosomes. Addition of cationic virosomes (75-150 microl) containing antisense L-myc OPT in the picomolar range to small-cell-lung-cancer (SCLC) cell cultures that expressed highly the L-myc oncogene led to strong inhibition of thymidine incorporation in a concentration-dependent manner. Virosome-entrapped sense L-myc OPT and random-order OPT had only minimal effects on the thymidine uptake. Cells of SCLC cell line NCI-H82 expressing a very low level of L-myc were not affected by antisense-L-myc virosomes. In Western-blot analysis, expression of L-myc protein was suppressed in the antisense-virosome-treated NCI-H209 cells but not in untreated control NCI-H209 cells. These results suggest that cationic virosomes may have great potential as an efficient delivery system for antisense oligonucleotides in cancer therapy." @default.
- W2011467013 created "2016-06-24" @default.
- W2011467013 creator A5052006755 @default.
- W2011467013 creator A5052120678 @default.
- W2011467013 date "1998-08-31" @default.
- W2011467013 modified "2023-10-16" @default.
- W2011467013 title "Delivery to cancer cells of antisense L-myc oligonucleotides incorporated in fusogenic, cationic-lipid-reconstituted influenza-virus envelopes (cationic virosomes)" @default.
- W2011467013 cites W1752221293 @default.
- W2011467013 cites W1869466296 @default.
- W2011467013 cites W1971290197 @default.
- W2011467013 cites W1975381946 @default.
- W2011467013 cites W1976983945 @default.
- W2011467013 cites W1991303534 @default.
- W2011467013 cites W1999373563 @default.
- W2011467013 cites W1999598401 @default.
- W2011467013 cites W2000197169 @default.
- W2011467013 cites W2015085861 @default.
- W2011467013 cites W2048119963 @default.
- W2011467013 cites W2050971104 @default.
- W2011467013 cites W2073154386 @default.
- W2011467013 cites W2074685112 @default.
- W2011467013 cites W2081884104 @default.
- W2011467013 cites W2143555562 @default.
- W2011467013 cites W2156354112 @default.
- W2011467013 doi "https://doi.org/10.1002/(sici)1097-0215(19980831)77:5<728::aid-ijc11>3.0.co;2-y" @default.
- W2011467013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9688306" @default.
- W2011467013 hasPublicationYear "1998" @default.
- W2011467013 type Work @default.
- W2011467013 sameAs 2011467013 @default.
- W2011467013 citedByCount "57" @default.
- W2011467013 countsByYear W20114670132012 @default.
- W2011467013 countsByYear W20114670132013 @default.
- W2011467013 countsByYear W20114670132014 @default.
- W2011467013 countsByYear W20114670132015 @default.
- W2011467013 countsByYear W20114670132016 @default.
- W2011467013 countsByYear W20114670132017 @default.
- W2011467013 countsByYear W20114670132021 @default.
- W2011467013 crossrefType "journal-article" @default.
- W2011467013 hasAuthorship W2011467013A5052006755 @default.
- W2011467013 hasAuthorship W2011467013A5052120678 @default.
- W2011467013 hasBestOaLocation W20114670131 @default.
- W2011467013 hasConcept C129312508 @default.
- W2011467013 hasConcept C1491633281 @default.
- W2011467013 hasConcept C153911025 @default.
- W2011467013 hasConcept C155887181 @default.
- W2011467013 hasConcept C159047783 @default.
- W2011467013 hasConcept C185592680 @default.
- W2011467013 hasConcept C2522874641 @default.
- W2011467013 hasConcept C2778692840 @default.
- W2011467013 hasConcept C28005876 @default.
- W2011467013 hasConcept C54009773 @default.
- W2011467013 hasConcept C54355233 @default.
- W2011467013 hasConcept C552990157 @default.
- W2011467013 hasConcept C55493867 @default.
- W2011467013 hasConcept C81885089 @default.
- W2011467013 hasConcept C86803240 @default.
- W2011467013 hasConceptScore W2011467013C129312508 @default.
- W2011467013 hasConceptScore W2011467013C1491633281 @default.
- W2011467013 hasConceptScore W2011467013C153911025 @default.
- W2011467013 hasConceptScore W2011467013C155887181 @default.
- W2011467013 hasConceptScore W2011467013C159047783 @default.
- W2011467013 hasConceptScore W2011467013C185592680 @default.
- W2011467013 hasConceptScore W2011467013C2522874641 @default.
- W2011467013 hasConceptScore W2011467013C2778692840 @default.
- W2011467013 hasConceptScore W2011467013C28005876 @default.
- W2011467013 hasConceptScore W2011467013C54009773 @default.
- W2011467013 hasConceptScore W2011467013C54355233 @default.
- W2011467013 hasConceptScore W2011467013C552990157 @default.
- W2011467013 hasConceptScore W2011467013C55493867 @default.
- W2011467013 hasConceptScore W2011467013C81885089 @default.
- W2011467013 hasConceptScore W2011467013C86803240 @default.
- W2011467013 hasIssue "5" @default.
- W2011467013 hasLocation W20114670131 @default.
- W2011467013 hasLocation W20114670132 @default.
- W2011467013 hasOpenAccess W2011467013 @default.
- W2011467013 hasPrimaryLocation W20114670131 @default.
- W2011467013 hasRelatedWork W1517300360 @default.
- W2011467013 hasRelatedWork W1980369000 @default.
- W2011467013 hasRelatedWork W1991456836 @default.
- W2011467013 hasRelatedWork W2000295852 @default.
- W2011467013 hasRelatedWork W2061893926 @default.
- W2011467013 hasRelatedWork W2095562625 @default.
- W2011467013 hasRelatedWork W2318909117 @default.
- W2011467013 hasRelatedWork W2358205972 @default.
- W2011467013 hasRelatedWork W378297635 @default.
- W2011467013 hasRelatedWork W2515734071 @default.
- W2011467013 hasVolume "77" @default.
- W2011467013 isParatext "false" @default.
- W2011467013 isRetracted "false" @default.
- W2011467013 magId "2011467013" @default.
- W2011467013 workType "article" @default.