Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011470724> ?p ?o ?g. }
- W2011470724 endingPage "198" @default.
- W2011470724 startingPage "190" @default.
- W2011470724 abstract "Influenza virus infection can cause severe complications in human immunodeficiency virus type-1 (HIV-1)-infected individuals leading to an increased risk of complications and death compared to that seen in uninfected individuals. We assessed the capacity of influenza virus (Flu) to modulate transcription of the HIV-1 long terminal repeat (LTR) in human CD4+ T cells. We found that Flu is able to promote expression of both the transiently transfected and stably integrated HIV-1 LTR-driven reporter gene. Experiments performed with Arthrobacter-derived neuraminidase and ammonium chloride revealed that Flu-dependent activation of HIV-1 transcription required an intimate contact between Flu and the target cell and efficient entry of Flu inside human CD4+ T cells. Amplification of a Flu-specific mRNA by RT-PCR indicated that human T cells were indeed productively infected with Flu. Virus preparations rendered noninfectious after UV irradiation could no longer upregulate HIV-1 LTR activity. Furthermore, experiments conducted with wild type and NF-κB-mutated HIV-1 LTR-directed reporter vectors suggested that the positive action of Flu on HIV-1 LTR activity was mediated through the induction of NF-κB. Our data show that fully competent Flu can lead to NF-κB-dependent activation of HIV-1 transcription in CD4+ T cells." @default.
- W2011470724 created "2016-06-24" @default.
- W2011470724 creator A5005502155 @default.
- W2011470724 creator A5005935743 @default.
- W2011470724 creator A5039852039 @default.
- W2011470724 creator A5073259394 @default.
- W2011470724 creator A5090418892 @default.
- W2011470724 date "2005-02-01" @default.
- W2011470724 modified "2023-10-07" @default.
- W2011470724 title "Influenza virus activates human immunodeficiency virus type-1 gene expression in human CD4-expressing T cells through an NF-κB-dependent pathway" @default.
- W2011470724 cites W1521747102 @default.
- W2011470724 cites W1536703863 @default.
- W2011470724 cites W1559780175 @default.
- W2011470724 cites W1565917249 @default.
- W2011470724 cites W1574277876 @default.
- W2011470724 cites W1604267887 @default.
- W2011470724 cites W1659719610 @default.
- W2011470724 cites W1771500607 @default.
- W2011470724 cites W1966623111 @default.
- W2011470724 cites W1978913285 @default.
- W2011470724 cites W1983946936 @default.
- W2011470724 cites W1987189799 @default.
- W2011470724 cites W1994882085 @default.
- W2011470724 cites W1995152884 @default.
- W2011470724 cites W2008412982 @default.
- W2011470724 cites W2009516666 @default.
- W2011470724 cites W2011303568 @default.
- W2011470724 cites W2017832395 @default.
- W2011470724 cites W2022931362 @default.
- W2011470724 cites W2023243934 @default.
- W2011470724 cites W2026452856 @default.
- W2011470724 cites W2027384581 @default.
- W2011470724 cites W2030338113 @default.
- W2011470724 cites W2036015085 @default.
- W2011470724 cites W2039224805 @default.
- W2011470724 cites W2044584901 @default.
- W2011470724 cites W2045530942 @default.
- W2011470724 cites W2051465469 @default.
- W2011470724 cites W2058131526 @default.
- W2011470724 cites W2064050331 @default.
- W2011470724 cites W2073231427 @default.
- W2011470724 cites W2079999509 @default.
- W2011470724 cites W2086468039 @default.
- W2011470724 cites W2094663416 @default.
- W2011470724 cites W2100771432 @default.
- W2011470724 cites W2112139849 @default.
- W2011470724 cites W2112156608 @default.
- W2011470724 cites W2113993673 @default.
- W2011470724 cites W2114881519 @default.
- W2011470724 cites W2122691081 @default.
- W2011470724 cites W2125284130 @default.
- W2011470724 cites W2128364566 @default.
- W2011470724 cites W2131076468 @default.
- W2011470724 cites W2132187263 @default.
- W2011470724 cites W2146585942 @default.
- W2011470724 cites W2154116964 @default.
- W2011470724 cites W2158884355 @default.
- W2011470724 cites W2163146557 @default.
- W2011470724 cites W2165117243 @default.
- W2011470724 cites W2169294522 @default.
- W2011470724 cites W2169565071 @default.
- W2011470724 cites W2253990994 @default.
- W2011470724 cites W2406500641 @default.
- W2011470724 cites W4233722283 @default.
- W2011470724 doi "https://doi.org/10.1016/j.clim.2004.10.002" @default.
- W2011470724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15639653" @default.
- W2011470724 hasPublicationYear "2005" @default.
- W2011470724 type Work @default.
- W2011470724 sameAs 2011470724 @default.
- W2011470724 citedByCount "2" @default.
- W2011470724 crossrefType "journal-article" @default.
- W2011470724 hasAuthorship W2011470724A5005502155 @default.
- W2011470724 hasAuthorship W2011470724A5005935743 @default.
- W2011470724 hasAuthorship W2011470724A5039852039 @default.
- W2011470724 hasAuthorship W2011470724A5073259394 @default.
- W2011470724 hasAuthorship W2011470724A5090418892 @default.
- W2011470724 hasConcept C104317684 @default.
- W2011470724 hasConcept C138885662 @default.
- W2011470724 hasConcept C150194340 @default.
- W2011470724 hasConcept C159047783 @default.
- W2011470724 hasConcept C161733203 @default.
- W2011470724 hasConcept C179926584 @default.
- W2011470724 hasConcept C199491388 @default.
- W2011470724 hasConcept C2522874641 @default.
- W2011470724 hasConcept C2777546802 @default.
- W2011470724 hasConcept C2910020833 @default.
- W2011470724 hasConcept C41895202 @default.
- W2011470724 hasConcept C54009773 @default.
- W2011470724 hasConcept C55493867 @default.
- W2011470724 hasConcept C86803240 @default.
- W2011470724 hasConcept C89423630 @default.
- W2011470724 hasConceptScore W2011470724C104317684 @default.
- W2011470724 hasConceptScore W2011470724C138885662 @default.
- W2011470724 hasConceptScore W2011470724C150194340 @default.
- W2011470724 hasConceptScore W2011470724C159047783 @default.
- W2011470724 hasConceptScore W2011470724C161733203 @default.
- W2011470724 hasConceptScore W2011470724C179926584 @default.
- W2011470724 hasConceptScore W2011470724C199491388 @default.