FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011485664> ?p ?o ?g. }

• W2011485664 endingPage "274" @default.
• W2011485664 startingPage "265" @default.
• W2011485664 abstract "This study's goal was to assess the safety of tumor-targeted interleukin-12 (ttIL-12) when administered by electrogenetherapy in C3H/HeJ mice by identifying an initial safe dose for human dose escalation schemes, toxicity target organs, markers of toxicity, and toxicity reversibility. Tumor-free mice receiving two doses of 0.45% NaCl, 1 μg ttIL-12 DNA in 0.45% NaCl or 5 μg ttIL-12 DNA in 0.45% NaCl, 10 days apart combined with low-intensity electroporation were compared with non-treatment controls over time. All mice had blood cell counts, serum chemistry profiles, plasma interleukin-12 and IFNγ determinations, necropsy and multi-organ histopathology. Mild treatment-associated changes included electroporation-associated muscle changes that resolved by 30 days; decreased total white blood cell counts and infectious disease in the 5 μg ttIL-12 group, but not in the 1 μg group, and liver changes in ttIL-12 groups that correlated with alanine transaminase levels and resolved by 30 days. Dystrophic cardiac calcification seen in older, 5 μg ttIL-12-treated mice was the only serious toxicity. Based on these results and the lack of any effect on wound healing when combined with surgery, low-intensity electrogenetherapy with ttIL-12 appears to be safe and well tolerated." @default.
• W2011485664 created "2016-06-24" @default.
• W2011485664 creator A5055203050 @default.
• W2011485664 creator A5056887377 @default.
• W2011485664 date "2011-01-14" @default.
• W2011485664 modified "2023-10-17" @default.
• W2011485664 title "Pre-clinical toxicity assessment of tumor-targeted interleukin-12 low-intensity electrogenetherapy" @default.
• W2011485664 cites W140736463 @default.
• W2011485664 cites W1521747187 @default.
• W2011485664 cites W157631173 @default.
• W2011485664 cites W1609710757 @default.
• W2011485664 cites W1644502582 @default.
• W2011485664 cites W1966226199 @default.
• W2011485664 cites W1972279923 @default.
• W2011485664 cites W1986046059 @default.
• W2011485664 cites W2012095846 @default.
• W2011485664 cites W2021096348 @default.
• W2011485664 cites W2042106455 @default.
• W2011485664 cites W2067971586 @default.
• W2011485664 cites W2077989877 @default.
• W2011485664 cites W2114914602 @default.
• W2011485664 cites W2122387392 @default.
• W2011485664 cites W2129319296 @default.
• W2011485664 cites W2133053113 @default.
• W2011485664 cites W2151707711 @default.
• W2011485664 cites W2165625329 @default.
• W2011485664 cites W2166612314 @default.
• W2011485664 cites W2426629469 @default.
• W2011485664 cites W249403745 @default.
• W2011485664 doi "https://doi.org/10.1038/cgt.2010.77" @default.
• W2011485664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3415231" @default.
• W2011485664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21233859" @default.
• W2011485664 hasPublicationYear "2011" @default.
• W2011485664 type Work @default.
• W2011485664 sameAs 2011485664 @default.
• W2011485664 citedByCount "7" @default.
• W2011485664 countsByYear W20114856642012 @default.
• W2011485664 countsByYear W20114856642014 @default.
• W2011485664 countsByYear W20114856642019 @default.
• W2011485664 countsByYear W20114856642020 @default.
• W2011485664 countsByYear W20114856642022 @default.
• W2011485664 countsByYear W20114856642023 @default.
• W2011485664 crossrefType "journal-article" @default.
• W2011485664 hasAuthorship W2011485664A5055203050 @default.
• W2011485664 hasAuthorship W2011485664A5056887377 @default.
• W2011485664 hasBestOaLocation W20114856642 @default.
• W2011485664 hasConcept C126322002 @default.
• W2011485664 hasConcept C142724271 @default.
• W2011485664 hasConcept C160160445 @default.
• W2011485664 hasConcept C181199279 @default.
• W2011485664 hasConcept C2778488018 @default.
• W2011485664 hasConcept C2778606649 @default.
• W2011485664 hasConcept C2778690821 @default.
• W2011485664 hasConcept C2779679107 @default.
• W2011485664 hasConcept C29730261 @default.
• W2011485664 hasConcept C544855455 @default.
• W2011485664 hasConcept C55493867 @default.
• W2011485664 hasConcept C71924100 @default.
• W2011485664 hasConcept C74172505 @default.
• W2011485664 hasConcept C86803240 @default.
• W2011485664 hasConcept C90924648 @default.
• W2011485664 hasConcept C98274493 @default.
• W2011485664 hasConceptScore W2011485664C126322002 @default.
• W2011485664 hasConceptScore W2011485664C142724271 @default.
• W2011485664 hasConceptScore W2011485664C160160445 @default.
• W2011485664 hasConceptScore W2011485664C181199279 @default.
• W2011485664 hasConceptScore W2011485664C2778488018 @default.
• W2011485664 hasConceptScore W2011485664C2778606649 @default.
• W2011485664 hasConceptScore W2011485664C2778690821 @default.
• W2011485664 hasConceptScore W2011485664C2779679107 @default.
• W2011485664 hasConceptScore W2011485664C29730261 @default.
• W2011485664 hasConceptScore W2011485664C544855455 @default.
• W2011485664 hasConceptScore W2011485664C55493867 @default.
• W2011485664 hasConceptScore W2011485664C71924100 @default.
• W2011485664 hasConceptScore W2011485664C74172505 @default.
• W2011485664 hasConceptScore W2011485664C86803240 @default.
• W2011485664 hasConceptScore W2011485664C90924648 @default.
• W2011485664 hasConceptScore W2011485664C98274493 @default.
• W2011485664 hasIssue "4" @default.
• W2011485664 hasLocation W20114856641 @default.
• W2011485664 hasLocation W20114856642 @default.
• W2011485664 hasLocation W20114856643 @default.
• W2011485664 hasLocation W20114856644 @default.
• W2011485664 hasOpenAccess W2011485664 @default.
• W2011485664 hasPrimaryLocation W20114856641 @default.
• W2011485664 hasRelatedWork W1128426743 @default.
• W2011485664 hasRelatedWork W1768272278 @default.
• W2011485664 hasRelatedWork W2091355127 @default.
• W2011485664 hasRelatedWork W2153203426 @default.
• W2011485664 hasRelatedWork W2941273873 @default.
• W2011485664 hasRelatedWork W3028867733 @default.
• W2011485664 hasRelatedWork W3043569009 @default.
• W2011485664 hasRelatedWork W4232069147 @default.
• W2011485664 hasRelatedWork W4248389488 @default.
• W2011485664 hasRelatedWork W2660217500 @default.
• W2011485664 hasVolume "18" @default.
• W2011485664 isParatext "false" @default.
• W2011485664 isRetracted "false" @default.

• next