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- W2011486274 abstract "Abstract Integrase (IN) is an essential enzyme in the human immunodeficiency virus type-1 (HIV-1) replication cycle and, thus, a potential target for chemotherapeutic agents. Because various nucleotide analogues have been reported to inhibit IN in vitro, we investigated the effect of acyclic nucleoside phosphonates. Both unphosphorylated and diphosphorylated derivatives were inhibitory to IN at concentrations ranging between 60 and 800 μM, with diphosphorylated derivatives being 5- to 8-fold more potent than unphosphorylated counterparts." @default.
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- W2011486274 date "1999-04-01" @default.
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- W2011486274 title "Effect of Acyclic Nucleoside Phosphonates on the HIV-1 Integrase in Vitro" @default.
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- W2011486274 doi "https://doi.org/10.1080/15257779908041579" @default.
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