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• W2011491605 abstract "Fibulin-5 (FBLN-5) is a widely expressed, integrin-binding extracellular matrix protein that mediates endothelial cell adhesion and scaffolds cells to elastic fibers. It is also a gene target of TGF-β in fibroblasts and endothelial cells that regulates cell proliferation and motility in a context-specific manner. Whereas FBLN-5 expression is low in adult vasculature, its expression is high in developing and injured vasculature, implicating FBLN-5 in regulating angiogenesis and endothelial cell function. We show here that TGF-β stimulates FBLN-5 expression in endothelial cells, and that this response was inhibited by coadministration of the proangiogenic factor, VEGF. FBLN-5 expression was downregulated significantly during endothelial cell tubulogenesis, implying that FBLN-5 expression antagonizes angiogenesis. Accordingly, FBLN-5 overexpression in or recombinant FBLN-5 treatment of endothelial cells abrogated their ability to undergo angiogenic sprouting, doing so by inhibiting endothelial cell proliferation and invasion through Matrigel matrices. Moreover, FBLN-5 antagonized VEGF signaling in endothelial cells, as well as enhanced their expression of the antiangiogenic factor, thrombospondin-1. Finally, the ability of FBLN-5 to antagonize angiogenic processes was determined to be independent of its integrin-binding RGD motif. Collectively, our findings establish FBLN-5 as a novel antagonist of angiogenesis and endothelial cell activities, and offer new insights into why tumorigenesis downregulates FBLN-5 expression." @default.
• W2011491605 created "2016-06-24" @default.
• W2011491605 creator A5008646329 @default.
• W2011491605 creator A5090145675 @default.
• W2011491605 date "2004-06-01" @default.
• W2011491605 modified "2023-09-25" @default.
• W2011491605 title "Fibulin-5 Antagonizes Vascular Endothelial Growth Factor (VEGF) Signaling and Angiogenic Sprouting by Endothelial Cells" @default.
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• W2011491605 doi "https://doi.org/10.1089/104454904323145254" @default.
• W2011491605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15231070" @default.
• W2011491605 hasPublicationYear "2004" @default.
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