FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011492248> ?p ?o ?g. }

• W2011492248 endingPage "458" @default.
• W2011492248 startingPage "451" @default.
• W2011492248 abstract "Fifty years since Peter Mitchell proposed the theory of chemiosmosis, the transformation of cellular redox potential into ATP synthetic capacity is still a widely recognized function of mitochondria. Mitchell used the term ‘proticity’ to describe the force and flow of the proton circuit across the inner membrane. When the proton gradient is coupled to ATP synthase activity, the conversion of fuel to ATP is efficient. However, uncoupling proteins (UCPs) can cause proton leaks resulting in poor fuel conversion efficiency, and some UCPs might control mitochondrial reactive oxygen species (ROS) production. Once viewed as toxic metabolic waste, ROS are now implicated in cell signaling and regulation. Here, we discuss the role of mitochondrial proticity in the context of ROS production and signaling. Fifty years since Peter Mitchell proposed the theory of chemiosmosis, the transformation of cellular redox potential into ATP synthetic capacity is still a widely recognized function of mitochondria. Mitchell used the term ‘proticity’ to describe the force and flow of the proton circuit across the inner membrane. When the proton gradient is coupled to ATP synthase activity, the conversion of fuel to ATP is efficient. However, uncoupling proteins (UCPs) can cause proton leaks resulting in poor fuel conversion efficiency, and some UCPs might control mitochondrial reactive oxygen species (ROS) production. Once viewed as toxic metabolic waste, ROS are now implicated in cell signaling and regulation. Here, we discuss the role of mitochondrial proticity in the context of ROS production and signaling. also called ADP/ATP translocator, it is a member of the mitochondrial inner membrane anion carrier superfamily. Integral membrane protein required for the antiport of ADP3− and ATP4− (ADP3− import in exchange for ATP4− export). Also thought to play other roles in mitochondria including basal proton leak, MPTP structure, and maintenance of cristae integrity. also known as chemiosmosis. Electron transfer along the respiratory chain establishes an electrochemical proton gradient, referred to as protonmotive force (PMF) across the selectively permeable mitochondrial inner membrane. PMF is subsequently used to drive the activity of ATP synthase for ATP production. a post-translational modification involving the formation of a disulfide bond between glutathione and available/reactive cysteine thiols on proteins. composed of several mitochondrial proteins including ANT. MPTP is a nonselective pore that permeabilizes the mitochondrial inner membrane to molecules <1500 Da in size. Assembly and opening normally associated with various pathologies and cell death. a form of electricity generated by mitochondria characterized by the flow of protons, instead of electrons, in the proton circuit from high to low protic potential. The electrochemical potential across the mitochondrial inner membrane. Consists of a transmembrane difference in electric potential (Δψ) and a transmembrane difference in pH (ΔpH). Drives the translocation of several ions and metabolites across the membrane, including H+ via ATP synthase. highly reactive oxygen-containing molecules. ROS are generated spontaneously or by cellular enzymes. Although most ROS species carry unpaired electrons in their outer valence shells, exceptions include hydrogen peroxide. member of the mitochondrial inner membrane anion carrier superfamily. UCP can ‘leak’ protons down the electrochemical gradient (or PMF) from the mitochondrial intermembrane space into the mitochondrial matrix. UCP lowers PMF available for ATP synthase activity. Leak through the UCPs is controlled allosterically (e.g. by purine nucleotides and fatty acids), and at least some UCPs (e.g. UCP2 and UCP3) are controlled by post-translational modification (i.e. glutathionylation). Uncoupling serves a broad range of functions including thermoregulation (UCP1 in brown adipose tissue) and control of mitochondrial ROS production (UCPs 2–4)." @default.
• W2011492248 created "2016-06-24" @default.
• W2011492248 creator A5014760843 @default.
• W2011492248 creator A5061668188 @default.
• W2011492248 date "2012-09-01" @default.
• W2011492248 modified "2023-10-17" @default.
• W2011492248 title "Mitochondrial proticity and ROS signaling: lessons from the uncoupling proteins" @default.
• W2011492248 cites W1597213042 @default.
• W2011492248 cites W1610305067 @default.
• W2011492248 cites W1640170395 @default.
• W2011492248 cites W1699447737 @default.
• W2011492248 cites W1813230101 @default.
• W2011492248 cites W1920447776 @default.
• W2011492248 cites W1925799544 @default.
• W2011492248 cites W1964126982 @default.
• W2011492248 cites W1967315314 @default.
• W2011492248 cites W1969181138 @default.
• W2011492248 cites W1973475159 @default.
• W2011492248 cites W1974217398 @default.
• W2011492248 cites W1975090760 @default.
• W2011492248 cites W1979048203 @default.
• W2011492248 cites W1984156802 @default.
• W2011492248 cites W1986956461 @default.
• W2011492248 cites W1987762190 @default.
• W2011492248 cites W1993039541 @default.
• W2011492248 cites W1995190951 @default.
• W2011492248 cites W1998596519 @default.
• W2011492248 cites W2009785737 @default.
• W2011492248 cites W2010712769 @default.
• W2011492248 cites W2011866187 @default.
• W2011492248 cites W2014058353 @default.
• W2011492248 cites W2015221597 @default.
• W2011492248 cites W2018141062 @default.
• W2011492248 cites W2020168780 @default.
• W2011492248 cites W2020498032 @default.
• W2011492248 cites W2025038110 @default.
• W2011492248 cites W2026738371 @default.
• W2011492248 cites W2028132430 @default.
• W2011492248 cites W2028142112 @default.
• W2011492248 cites W2036573181 @default.
• W2011492248 cites W2038216672 @default.
• W2011492248 cites W2040856926 @default.
• W2011492248 cites W2042149164 @default.
• W2011492248 cites W2042959152 @default.
• W2011492248 cites W2047128756 @default.
• W2011492248 cites W2051859853 @default.
• W2011492248 cites W2057430342 @default.
• W2011492248 cites W2057973123 @default.
• W2011492248 cites W2058249580 @default.
• W2011492248 cites W2059700478 @default.
• W2011492248 cites W2073446096 @default.
• W2011492248 cites W2075529886 @default.
• W2011492248 cites W2076687053 @default.
• W2011492248 cites W2077404125 @default.
• W2011492248 cites W2077506711 @default.
• W2011492248 cites W2084034472 @default.
• W2011492248 cites W2085869920 @default.
• W2011492248 cites W2086501334 @default.
• W2011492248 cites W2087598382 @default.
• W2011492248 cites W2088658333 @default.
• W2011492248 cites W2089855345 @default.
• W2011492248 cites W2090848174 @default.
• W2011492248 cites W2092394448 @default.
• W2011492248 cites W2093687559 @default.
• W2011492248 cites W2094932063 @default.
• W2011492248 cites W2096686378 @default.
• W2011492248 cites W2109407065 @default.
• W2011492248 cites W2112947221 @default.
• W2011492248 cites W2114077740 @default.
• W2011492248 cites W2114821999 @default.
• W2011492248 cites W2115167405 @default.
• W2011492248 cites W2115708356 @default.
• W2011492248 cites W2121445788 @default.
• W2011492248 cites W2121956021 @default.
• W2011492248 cites W2122341467 @default.
• W2011492248 cites W2122790459 @default.
• W2011492248 cites W2123226016 @default.
• W2011492248 cites W2125126193 @default.
• W2011492248 cites W2128879584 @default.
• W2011492248 cites W2132878122 @default.
• W2011492248 cites W2133486230 @default.
• W2011492248 cites W2133966054 @default.
• W2011492248 cites W2134532539 @default.
• W2011492248 cites W2136867132 @default.
• W2011492248 cites W2141950542 @default.
• W2011492248 cites W2142251961 @default.
• W2011492248 cites W2143505819 @default.
• W2011492248 cites W2144357175 @default.
• W2011492248 cites W2160222676 @default.
• W2011492248 cites W2161869914 @default.
• W2011492248 cites W2162707945 @default.
• W2011492248 cites W2165623186 @default.
• W2011492248 cites W2165725371 @default.
• W2011492248 cites W2166902551 @default.
• W2011492248 cites W2167207642 @default.
• W2011492248 cites W2167376898 @default.
• W2011492248 cites W2167734608 @default.
• W2011492248 cites W2271272206 @default.

• next