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- W2011492944 abstract "No AccessJournal of UrologyInvestigative Urology1 Aug 2010Olfactory Mucosal Transplantation After Spinal Cord Injury Improves Voiding Efficiency by Suppressing Detrusor-Sphincter Dyssynergia in Rats Jiro Nakayama, Tetsuya Takao, Hiroshi Kiuchi, Keisuke Yamamoto, Shinichiro Fukuhara, Yasushi Miyagawa, Masanori Aoki, Koichi Iwatsuki, Toshiki Yoshimine, Masaki Ueno, Toshihide Yamashita, Norio Nonomura, Akira Tsujimura, and Akihiko Okuyama Jiro NakayamaJiro Nakayama Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Tetsuya TakaoTetsuya Takao Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Hiroshi KiuchiHiroshi Kiuchi Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Keisuke YamamotoKeisuke Yamamoto Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Shinichiro FukuharaShinichiro Fukuhara Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Yasushi MiyagawaYasushi Miyagawa Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Masanori AokiMasanori Aoki Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Koichi IwatsukiKoichi Iwatsuki Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Toshiki YoshimineToshiki Yoshimine Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Masaki UenoMasaki Ueno Department of Molecular Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Toshihide YamashitaToshihide Yamashita Department of Molecular Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Norio NonomuraNorio Nonomura Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , Akira TsujimuraAkira Tsujimura Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author , and Akihiko OkuyamaAkihiko Okuyama Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.03.105AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Several recent studies showed that olfactory mucosal transplantation after spinal cord injury promotes extensive regeneration of the injured spinal cord. We examined the efficacy of olfactory mucosal transplantation for bladder dysfunction after spinal cord injury in rats. Materials and Methods: In adult female rats the Th9-10 spinal cord was completely transected, followed by olfactory mucosal transplantation or gelatin sponge filling as the control. Each group was examined by cystometrogram and external urethral sphincter electromyogram. Calcitonin gene-related peptide and growth associated protein 43 double positive expression in the L6/S1 dorsal horn was evaluated by immunohistochemistry. Transplant sites were examined by immunohistochemistry with antibodies against neurofilament M and neuronal class III β-tubulin. Results: On cystometrogram voiding efficiency was significantly higher in the transplantation group than in controls. On external urethral sphincter electromyogram with simultaneous cystometrogram the transplantation group showed a larger ratio of interburst silent periods to burst activity duration and a greater number of high frequency oscillations. In the transplantation group calcitonin gene-related peptide and growth associated protein 43 double positive expression in the L6/S1 dorsal horn was less dense than in controls. The transplantation group showed strong neurofilament M and neuronal class III β-tubulin expression at the transplant site. Conclusions: Olfactory mucosal transplantation after spinal cord injury weakened external urethral sphincter excessive bursting and increased the urethral opening to improve voiding efficiency. Olfactory mucosal transplantation may modify emergence of the spinal micturition reflex after spinal cord injury. 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Google Scholar © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 184Issue 2August 2010Page: 775-782 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.Keywordsspinal cord injuriesolfactory mucosatransplantationurination disordersurethraAcknowledgmentsDr. Mitsuharu Yoshiyama, Yumura Onsen Hospital, assisted with discussion.MetricsAuthor Information Jiro Nakayama Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Tetsuya Takao Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Hiroshi Kiuchi Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Keisuke Yamamoto Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Shinichiro Fukuhara Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Yasushi Miyagawa Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Masanori Aoki Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Koichi Iwatsuki Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Toshiki Yoshimine Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Masaki Ueno Department of Molecular Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Toshihide Yamashita Department of Molecular Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Norio Nonomura Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Akira Tsujimura Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Akihiko Okuyama Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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