FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011496738> ?p ?o ?g. }

• W2011496738 endingPage "10" @default.
• W2011496738 startingPage "4" @default.
• W2011496738 abstract "The pathogenesis of systemic lupus erythematosus (SLE) is incompletely understood. Studies in both lupus animal models and human disease indicate a clear role for epigenetic defects, particularly DNA methylation, in the pathogenesis of lupus. T-cell DNA from active lupus patients is hypomethylated, which results in overexpression of methylation-regulated genes, T-cell autoreactivity, and autoimmunity in vivo. Inducing an extracellular signal-regulated kinase (ERK) signaling defect in T cells using a transgenic mouse model resulted in reduced DNA methyltransferase 1 (DNMT1) expression, overexpression of methylation-sensitive genes, and anti-double-stranded DNA (anti-dsDNA) antibody production. ERK signaling is known to be defective in lupus T cells, and this defect is now explained by impaired T-cell protein kinase C (PKC) delta activation. Herein, we discuss how defective epigenetic regulation is involved in the pathogenesis of lupus, which includes both DNA methylation and histone modification changes." @default.
• W2011496738 created "2016-06-24" @default.
• W2011496738 creator A5002494862 @default.
• W2011496738 creator A5033234706 @default.
• W2011496738 date "2009-01-01" @default.
• W2011496738 modified "2023-10-18" @default.
• W2011496738 title "Epigenetic regulation and the pathogenesis of systemic lupus erythematosus" @default.
• W2011496738 cites W1538430276 @default.
• W2011496738 cites W1567305408 @default.
• W2011496738 cites W1743309991 @default.
• W2011496738 cites W1831776830 @default.
• W2011496738 cites W1963746213 @default.
• W2011496738 cites W1965381235 @default.
• W2011496738 cites W1968679842 @default.
• W2011496738 cites W1986803917 @default.
• W2011496738 cites W1987527321 @default.
• W2011496738 cites W1994009027 @default.
• W2011496738 cites W1995665375 @default.
• W2011496738 cites W1996626475 @default.
• W2011496738 cites W1998631235 @default.
• W2011496738 cites W1999023151 @default.
• W2011496738 cites W2002698073 @default.
• W2011496738 cites W2008261028 @default.
• W2011496738 cites W2014912378 @default.
• W2011496738 cites W2018370288 @default.
• W2011496738 cites W2020699105 @default.
• W2011496738 cites W2021273693 @default.
• W2011496738 cites W2022081039 @default.
• W2011496738 cites W2034583127 @default.
• W2011496738 cites W2039276157 @default.
• W2011496738 cites W2043688150 @default.
• W2011496738 cites W2047396455 @default.
• W2011496738 cites W2054545444 @default.
• W2011496738 cites W2066322522 @default.
• W2011496738 cites W2075907707 @default.
• W2011496738 cites W2078675651 @default.
• W2011496738 cites W2080040722 @default.
• W2011496738 cites W2090103702 @default.
• W2011496738 cites W2092550414 @default.
• W2011496738 cites W2093342054 @default.
• W2011496738 cites W2106273198 @default.
• W2011496738 cites W2106655704 @default.
• W2011496738 cites W2108639843 @default.
• W2011496738 cites W2113520107 @default.
• W2011496738 cites W2114037935 @default.
• W2011496738 cites W2115337562 @default.
• W2011496738 cites W2119449850 @default.
• W2011496738 cites W2123095447 @default.
• W2011496738 cites W2127146201 @default.
• W2011496738 cites W2135658911 @default.
• W2011496738 cites W2137798131 @default.
• W2011496738 cites W2138825245 @default.
• W2011496738 cites W2150606117 @default.
• W2011496738 cites W2161993805 @default.
• W2011496738 cites W2168888135 @default.
• W2011496738 cites W2171524621 @default.
• W2011496738 doi "https://doi.org/10.1016/j.trsl.2008.10.007" @default.
• W2011496738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19100952" @default.
• W2011496738 hasPublicationYear "2009" @default.
• W2011496738 type Work @default.
• W2011496738 sameAs 2011496738 @default.
• W2011496738 citedByCount "86" @default.
• W2011496738 countsByYear W20114967382012 @default.
• W2011496738 countsByYear W20114967382013 @default.
• W2011496738 countsByYear W20114967382014 @default.
• W2011496738 countsByYear W20114967382015 @default.
• W2011496738 countsByYear W20114967382016 @default.
• W2011496738 countsByYear W20114967382017 @default.
• W2011496738 countsByYear W20114967382018 @default.
• W2011496738 countsByYear W20114967382019 @default.
• W2011496738 countsByYear W20114967382020 @default.
• W2011496738 countsByYear W20114967382021 @default.
• W2011496738 countsByYear W20114967382022 @default.
• W2011496738 countsByYear W20114967382023 @default.
• W2011496738 crossrefType "journal-article" @default.
• W2011496738 hasAuthorship W2011496738A5002494862 @default.
• W2011496738 hasAuthorship W2011496738A5033234706 @default.
• W2011496738 hasConcept C104317684 @default.
• W2011496738 hasConcept C142724271 @default.
• W2011496738 hasConcept C150194340 @default.
• W2011496738 hasConcept C159654299 @default.
• W2011496738 hasConcept C175211621 @default.
• W2011496738 hasConcept C190727270 @default.
• W2011496738 hasConcept C203014093 @default.
• W2011496738 hasConcept C2775915377 @default.
• W2011496738 hasConcept C2776912625 @default.
• W2011496738 hasConcept C2779134260 @default.
• W2011496738 hasConcept C2779979206 @default.
• W2011496738 hasConcept C2780130043 @default.
• W2011496738 hasConcept C2780942790 @default.
• W2011496738 hasConcept C33288867 @default.
• W2011496738 hasConcept C41091548 @default.
• W2011496738 hasConcept C502942594 @default.
• W2011496738 hasConcept C54355233 @default.
• W2011496738 hasConcept C64927066 @default.
• W2011496738 hasConcept C71924100 @default.
• W2011496738 hasConcept C86803240 @default.
• W2011496738 hasConceptScore W2011496738C104317684 @default.

• next