FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011501210> ?p ?o ?g. }

• W2011501210 endingPage "230" @default.
• W2011501210 startingPage "219" @default.
• W2011501210 abstract "<i>Background:</i> Recent clinical trials, epidemiological studies and animal experiments have suggested that probiotics may help suppress the development of allergic responses. <i>Objective:</i> To investigate whether the application of the probiotic <i>Escherichia coli</i> strain Nissle 1917 (EcN) protects mice from developing ovalbumin (OVA)-specific T helper-2 responses in the airways. <i>Methods:</i> OVA-specific Th2 responses were induced by 2 intraperitoneal (i.p.) injections with OVA/alum followed by 1 intranasal (i.n.) challenge with OVA. EcN was given orally during the entire sensitization and challenge period, together with OVA/alum during the i.p. sensitizations, or i.n. before or during the airway challenge with OVA. <i>Results:</i> We found that when the bacteria were given together with OVA/alum airway eosinophilia, airway hyper-reactivity, goblet cell metaplasia and IL-5 levels in the bronchoalveolar lavage and mediastinal lymph node cell cultures were reduced. This effect was associated with increased numbers of IFN-γ producing T helper-1 cells and IFN-γ levels in the airways and strongly increased OVA-specific IgG_2a titers in the serum. The suppressive effect on airway eosinophilia was dependent on IFN-γ but not TLR-4. Applying EcN i.n. or orally did not reduce the development of allergen-specific Th2 responses. <i>Conclusions:</i> Our results suggest that EcN can inhibit the development of allergic responses when the bacteria are present at the site of Th2 cell priming and that this immunomodulatory effect is due to a shift from Th2 to Th1 response. The data support the hypothesis that probiotics may help reduce allergic responses and that EcN may also be used as adjuvant therapy to induce allergen-specific Th1 responses." @default.
• W2011501210 created "2016-06-24" @default.
• W2011501210 creator A5003710894 @default.
• W2011501210 creator A5029206094 @default.
• W2011501210 creator A5039683677 @default.
• W2011501210 creator A5051165028 @default.
• W2011501210 creator A5070377988 @default.
• W2011501210 creator A5072519143 @default.
• W2011501210 creator A5077204945 @default.
• W2011501210 creator A5091613480 @default.
• W2011501210 date "2009-01-01" @default.
• W2011501210 modified "2023-10-16" @default.
• W2011501210 title "Probiotic <i>Escherichia coli </i>Nissle 1917 Suppresses Allergen-Induced Th2 Responses in the Airways" @default.
• W2011501210 cites W1979041581 @default.
• W2011501210 cites W2052679233 @default.
• W2011501210 cites W2079144441 @default.
• W2011501210 cites W2132418349 @default.
• W2011501210 cites W2139697959 @default.
• W2011501210 cites W2167265477 @default.
• W2011501210 cites W4235703039 @default.
• W2011501210 doi "https://doi.org/10.1159/000199717" @default.
• W2011501210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19218814" @default.
• W2011501210 hasPublicationYear "2009" @default.
• W2011501210 type Work @default.
• W2011501210 sameAs 2011501210 @default.
• W2011501210 citedByCount "41" @default.
• W2011501210 countsByYear W20115012102012 @default.
• W2011501210 countsByYear W20115012102013 @default.
• W2011501210 countsByYear W20115012102014 @default.
• W2011501210 countsByYear W20115012102015 @default.
• W2011501210 countsByYear W20115012102016 @default.
• W2011501210 countsByYear W20115012102017 @default.
• W2011501210 countsByYear W20115012102018 @default.
• W2011501210 countsByYear W20115012102019 @default.
• W2011501210 countsByYear W20115012102020 @default.
• W2011501210 countsByYear W20115012102021 @default.
• W2011501210 countsByYear W20115012102022 @default.
• W2011501210 countsByYear W20115012102023 @default.
• W2011501210 crossrefType "journal-article" @default.
• W2011501210 hasAuthorship W2011501210A5003710894 @default.
• W2011501210 hasAuthorship W2011501210A5029206094 @default.
• W2011501210 hasAuthorship W2011501210A5039683677 @default.
• W2011501210 hasAuthorship W2011501210A5051165028 @default.
• W2011501210 hasAuthorship W2011501210A5070377988 @default.
• W2011501210 hasAuthorship W2011501210A5072519143 @default.
• W2011501210 hasAuthorship W2011501210A5077204945 @default.
• W2011501210 hasAuthorship W2011501210A5091613480 @default.
• W2011501210 hasConcept C142724271 @default.
• W2011501210 hasConcept C203014093 @default.
• W2011501210 hasConcept C2775941134 @default.
• W2011501210 hasConcept C2776946954 @default.
• W2011501210 hasConcept C2777129736 @default.
• W2011501210 hasConcept C529295009 @default.
• W2011501210 hasConcept C71924100 @default.
• W2011501210 hasConcept C8891405 @default.
• W2011501210 hasConceptScore W2011501210C142724271 @default.
• W2011501210 hasConceptScore W2011501210C203014093 @default.
• W2011501210 hasConceptScore W2011501210C2775941134 @default.
• W2011501210 hasConceptScore W2011501210C2776946954 @default.
• W2011501210 hasConceptScore W2011501210C2777129736 @default.
• W2011501210 hasConceptScore W2011501210C529295009 @default.
• W2011501210 hasConceptScore W2011501210C71924100 @default.
• W2011501210 hasConceptScore W2011501210C8891405 @default.
• W2011501210 hasIssue "3" @default.
• W2011501210 hasLocation W20115012101 @default.
• W2011501210 hasLocation W20115012102 @default.
• W2011501210 hasOpenAccess W2011501210 @default.
• W2011501210 hasPrimaryLocation W20115012101 @default.
• W2011501210 hasRelatedWork W1963740306 @default.
• W2011501210 hasRelatedWork W1995884250 @default.
• W2011501210 hasRelatedWork W2000304253 @default.
• W2011501210 hasRelatedWork W2011501210 @default.
• W2011501210 hasRelatedWork W2034044876 @default.
• W2011501210 hasRelatedWork W2038477076 @default.
• W2011501210 hasRelatedWork W2140674811 @default.
• W2011501210 hasRelatedWork W2160601823 @default.
• W2011501210 hasRelatedWork W2161530489 @default.
• W2011501210 hasRelatedWork W2948830544 @default.
• W2011501210 hasVolume "149" @default.
• W2011501210 isParatext "false" @default.
• W2011501210 isRetracted "false" @default.
• W2011501210 magId "2011501210" @default.
• W2011501210 workType "article" @default.