FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011509980> ?p ?o ?g. }

• W2011509980 endingPage "77" @default.
• W2011509980 startingPage "68" @default.
• W2011509980 abstract "The dosing level and frequency of omalizumab are guided by a dosing table based on total serum immunoglobulin E (IgE) and bodyweight. Using a validated, mathematical simulation model (based on concentration data from 8 studies), we evaluated the impact of a revised omalizumab dosing table (every 4 weeks dosing regimen) on the pharmacokinetic and pharmacodynamic profiles of free and total IgE. Safety analysis, in patients with high levels of exposure to omalizumab, was done using data from the clinical and post-marketing databases. The model accurately predicted observed omalizumab, free and total IgE concentrations. After reaching steady-state, the average increase in exposure was 10%, even for patients with the highest concentrations at the upper 97.5th percentile. Free IgE suppression slightly increased in the initial phase, and slightly reduced at the trough of the dosing cycle, but average suppression remained similar for both regimens. The safety profile of omalizumab was similar for patients receiving higher or lower doses. Thus, doubling the dose of omalizumab, in a subset of patients receiving 225-300 mg of omalizumab (every 2 weeks dosing regimen) can efficiently suppress free IgE without compromising safety or efficacy." @default.
• W2011509980 created "2016-06-24" @default.
• W2011509980 creator A5021678540 @default.
• W2011509980 creator A5028028709 @default.
• W2011509980 creator A5058866214 @default.
• W2011509980 date "2015-02-01" @default.
• W2011509980 modified "2023-10-06" @default.
• W2011509980 title "Revision of omalizumab dosing table for dosing every 4 instead of 2 weeks for specific ranges of bodyweight and baseline IgE" @default.
• W2011509980 cites W1517386226 @default.
• W2011509980 cites W1592080890 @default.
• W2011509980 cites W1910182345 @default.
• W2011509980 cites W1967215794 @default.
• W2011509980 cites W1983832849 @default.
• W2011509980 cites W2004147651 @default.
• W2011509980 cites W2010216472 @default.
• W2011509980 cites W2011018995 @default.
• W2011509980 cites W2016277634 @default.
• W2011509980 cites W2029587541 @default.
• W2011509980 cites W2039164436 @default.
• W2011509980 cites W2042553471 @default.
• W2011509980 cites W2045625663 @default.
• W2011509980 cites W2062574496 @default.
• W2011509980 cites W2063778528 @default.
• W2011509980 cites W2085255857 @default.
• W2011509980 cites W2088638067 @default.
• W2011509980 cites W2097981132 @default.
• W2011509980 cites W2101960704 @default.
• W2011509980 cites W2110052844 @default.
• W2011509980 cites W2110500887 @default.
• W2011509980 cites W2160953471 @default.
• W2011509980 cites W2164367822 @default.
• W2011509980 cites W4312658601 @default.
• W2011509980 cites W4313333802 @default.
• W2011509980 cites W86085617 @default.
• W2011509980 doi "https://doi.org/10.1016/j.yrtph.2014.12.002" @default.
• W2011509980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25497995" @default.
• W2011509980 hasPublicationYear "2015" @default.
• W2011509980 type Work @default.
• W2011509980 sameAs 2011509980 @default.
• W2011509980 citedByCount "28" @default.
• W2011509980 countsByYear W20115099802016 @default.
• W2011509980 countsByYear W20115099802019 @default.
• W2011509980 countsByYear W20115099802020 @default.
• W2011509980 countsByYear W20115099802021 @default.
• W2011509980 countsByYear W20115099802022 @default.
• W2011509980 countsByYear W20115099802023 @default.
• W2011509980 crossrefType "journal-article" @default.
• W2011509980 hasAuthorship W2011509980A5021678540 @default.
• W2011509980 hasAuthorship W2011509980A5028028709 @default.
• W2011509980 hasAuthorship W2011509980A5058866214 @default.
• W2011509980 hasBestOaLocation W20115099801 @default.
• W2011509980 hasConcept C105795698 @default.
• W2011509980 hasConcept C111113717 @default.
• W2011509980 hasConcept C112705442 @default.
• W2011509980 hasConcept C122048520 @default.
• W2011509980 hasConcept C126322002 @default.
• W2011509980 hasConcept C141105273 @default.
• W2011509980 hasConcept C159654299 @default.
• W2011509980 hasConcept C203014093 @default.
• W2011509980 hasConcept C2777288759 @default.
• W2011509980 hasConcept C2778564945 @default.
• W2011509980 hasConcept C2781413609 @default.
• W2011509980 hasConcept C33923547 @default.
• W2011509980 hasConcept C71924100 @default.
• W2011509980 hasConcept C90924648 @default.
• W2011509980 hasConcept C98274493 @default.
• W2011509980 hasConceptScore W2011509980C105795698 @default.
• W2011509980 hasConceptScore W2011509980C111113717 @default.
• W2011509980 hasConceptScore W2011509980C112705442 @default.
• W2011509980 hasConceptScore W2011509980C122048520 @default.
• W2011509980 hasConceptScore W2011509980C126322002 @default.
• W2011509980 hasConceptScore W2011509980C141105273 @default.
• W2011509980 hasConceptScore W2011509980C159654299 @default.
• W2011509980 hasConceptScore W2011509980C203014093 @default.
• W2011509980 hasConceptScore W2011509980C2777288759 @default.
• W2011509980 hasConceptScore W2011509980C2778564945 @default.
• W2011509980 hasConceptScore W2011509980C2781413609 @default.
• W2011509980 hasConceptScore W2011509980C33923547 @default.
• W2011509980 hasConceptScore W2011509980C71924100 @default.
• W2011509980 hasConceptScore W2011509980C90924648 @default.
• W2011509980 hasConceptScore W2011509980C98274493 @default.
• W2011509980 hasIssue "1" @default.
• W2011509980 hasLocation W20115099801 @default.
• W2011509980 hasLocation W20115099802 @default.
• W2011509980 hasOpenAccess W2011509980 @default.
• W2011509980 hasPrimaryLocation W20115099801 @default.
• W2011509980 hasRelatedWork W1976159180 @default.
• W2011509980 hasRelatedWork W2004325424 @default.
• W2011509980 hasRelatedWork W2021319218 @default.
• W2011509980 hasRelatedWork W2110500887 @default.
• W2011509980 hasRelatedWork W2227061539 @default.
• W2011509980 hasRelatedWork W2992709639 @default.
• W2011509980 hasRelatedWork W3021369409 @default.
• W2011509980 hasRelatedWork W3174177415 @default.
• W2011509980 hasRelatedWork W4283757445 @default.
• W2011509980 hasRelatedWork W4284681976 @default.
• W2011509980 hasVolume "71" @default.
• W2011509980 isParatext "false" @default.

• next