Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011512341> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2011512341 endingPage "n/a" @default.
- W2011512341 startingPage "n/a" @default.
- W2011512341 abstract "GABAB autoreceptors inhibit release of GABA from GABAergic nerve terminals. Agonists of these receptors (e.g. baclofen) inhibit, whereas antagonists (e.g. (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid; Sch 50911) enhance release of the transmitter. The actions of thymol (2-isopropyl-5-methylphenol) and the structurally related compound 2-tert-butyl-4-methylphenol, (4MP) on the release of [3H]-GABA were examined in rat neocortical slices where the GABAergic nerves had been preloaded with [3H]-GABA and subsequently stimulated electrically on two occasions (S1 and S2). Test agents, baclofen and Sch 50911 were added to the superfusion medium prior to the second period of stimulation (S2). Stimulation-induced overflow (SIO) of [3H]-GABA as a consequence of these stimulations (SIO1 and SIO2) were calculated and the effects of agents determined by comparing the SIO2/SIO1 ratio in the presence of each agent with that in control tissue. Thymol potentiated the release of [3H]-GABA (EC50 170 μmol/L), an action reversed by baclofen (2 μmol/L). Baclofen alone had little effect on GABA release. Release of [3H]-GABA was inhibited by 4MP (IC50 3 μmol/L) and this effect was blocked by Sch 50911 (10 μmol/L). Alone, Sch 50911 markedly potentiated the release of GABA. These results imply that 4MP is an agonist of GABAB autoreceptors; however, further studies are needed to confirm that thymol is indeed a GABAB autoreceptor antagonist. Of interest are structural differences in these agents. Thymol has a propyl group in the ortho position relative to the phenolic hydroxyl, whereas in 4MP this is a butyl group and the methyl group moves from position 5 to 4. Whether one or both of these changes was responsible for the above actions is unknown." @default.
- W2011512341 created "2016-06-24" @default.
- W2011512341 creator A5008013016 @default.
- W2011512341 creator A5026855073 @default.
- W2011512341 creator A5071014323 @default.
- W2011512341 date "2014-08-01" @default.
- W2011512341 modified "2023-09-25" @default.
- W2011512341 title "Pharmacological actions of thymol and an analogue at GABABautoreceptors" @default.
- W2011512341 doi "https://doi.org/10.1111/1440-1681.12278" @default.
- W2011512341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25115309" @default.
- W2011512341 hasPublicationYear "2014" @default.
- W2011512341 type Work @default.
- W2011512341 sameAs 2011512341 @default.
- W2011512341 citedByCount "2" @default.
- W2011512341 countsByYear W20115123412017 @default.
- W2011512341 countsByYear W20115123412018 @default.
- W2011512341 crossrefType "journal-article" @default.
- W2011512341 hasAuthorship W2011512341A5008013016 @default.
- W2011512341 hasAuthorship W2011512341A5026855073 @default.
- W2011512341 hasAuthorship W2011512341A5071014323 @default.
- W2011512341 hasConcept C101027131 @default.
- W2011512341 hasConcept C134018914 @default.
- W2011512341 hasConcept C170493617 @default.
- W2011512341 hasConcept C185592680 @default.
- W2011512341 hasConcept C24998067 @default.
- W2011512341 hasConcept C2776885963 @default.
- W2011512341 hasConcept C2777278459 @default.
- W2011512341 hasConcept C2778938600 @default.
- W2011512341 hasConcept C2779177108 @default.
- W2011512341 hasConcept C2780642067 @default.
- W2011512341 hasConcept C2781201050 @default.
- W2011512341 hasConcept C43617362 @default.
- W2011512341 hasConcept C55493867 @default.
- W2011512341 hasConcept C71240020 @default.
- W2011512341 hasConcept C8439214 @default.
- W2011512341 hasConcept C86803240 @default.
- W2011512341 hasConcept C98274493 @default.
- W2011512341 hasConceptScore W2011512341C101027131 @default.
- W2011512341 hasConceptScore W2011512341C134018914 @default.
- W2011512341 hasConceptScore W2011512341C170493617 @default.
- W2011512341 hasConceptScore W2011512341C185592680 @default.
- W2011512341 hasConceptScore W2011512341C24998067 @default.
- W2011512341 hasConceptScore W2011512341C2776885963 @default.
- W2011512341 hasConceptScore W2011512341C2777278459 @default.
- W2011512341 hasConceptScore W2011512341C2778938600 @default.
- W2011512341 hasConceptScore W2011512341C2779177108 @default.
- W2011512341 hasConceptScore W2011512341C2780642067 @default.
- W2011512341 hasConceptScore W2011512341C2781201050 @default.
- W2011512341 hasConceptScore W2011512341C43617362 @default.
- W2011512341 hasConceptScore W2011512341C55493867 @default.
- W2011512341 hasConceptScore W2011512341C71240020 @default.
- W2011512341 hasConceptScore W2011512341C8439214 @default.
- W2011512341 hasConceptScore W2011512341C86803240 @default.
- W2011512341 hasConceptScore W2011512341C98274493 @default.
- W2011512341 hasLocation W20115123411 @default.
- W2011512341 hasLocation W20115123412 @default.
- W2011512341 hasOpenAccess W2011512341 @default.
- W2011512341 hasPrimaryLocation W20115123411 @default.
- W2011512341 hasRelatedWork W1973272812 @default.
- W2011512341 hasRelatedWork W1989515221 @default.
- W2011512341 hasRelatedWork W2011512341 @default.
- W2011512341 hasRelatedWork W2022052157 @default.
- W2011512341 hasRelatedWork W2035903046 @default.
- W2011512341 hasRelatedWork W2056711535 @default.
- W2011512341 hasRelatedWork W2083079540 @default.
- W2011512341 hasRelatedWork W2099949194 @default.
- W2011512341 hasRelatedWork W2423615186 @default.
- W2011512341 hasRelatedWork W2562149847 @default.
- W2011512341 isParatext "false" @default.
- W2011512341 isRetracted "false" @default.
- W2011512341 magId "2011512341" @default.
- W2011512341 workType "article" @default.