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- W2011527151 abstract "Embryonic stem (ES) cells hold great promise for treating degenerative diseases, including diabetes, Parkinson's, Alzheimer's, neural degeneration, and cardiomyopathies. This research is controversial to some because producing ES cells requires destroying embryos, which generally means human embryos. However, some of the surplus human embryos available from in vitro fertilization (IVF) clinics may have a high rate of genetic errors and therefore would be unsuitable for ES cell research. Although gross chromosome errors can readily be detected in ES cells, other anomalies such as mitochondrial DNA defects may have gone unrecognized. An insurmountable problem is that there are no human ES cells derived from in vivo-produced embryos to provide normal comparative data. In contrast, some monkey ES cell lines have been produced using in vivo-generated, normal embryos obtained from fertile animals; these can represent a gold standard for primate ES cells. In this review, we argue a need for strong research programs using rhesus monkey ES cells, conducted in parallel with studies on human ES and adult stem cells, to derive the maximum information about the biology of normal stem cells and to produce technical protocols for their directed differentiation into safe and functional replacement cells, tissues, and organs. In contrast, ES cell research using only human cell lines is likely to be incomplete, which could hinder research progress, and delay or diminish the effective application of ES cell technology to the treatment of human diseases." @default.
- W2011527151 created "2016-06-24" @default.
- W2011527151 creator A5040986425 @default.
- W2011527151 creator A5069135894 @default.
- W2011527151 creator A5069413174 @default.
- W2011527151 date "2005-06-01" @default.
- W2011527151 modified "2023-10-16" @default.
- W2011527151 title "Challenges of Primate Embryonic Stem Cell Research" @default.
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- W2011527151 doi "https://doi.org/10.1089/clo.2005.7.82" @default.
- W2011527151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15971982" @default.
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