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• W2011540282 abstract "An immune response against malaria has to be tightly controlled. The production of pro-inflammatory cytokines is required to control parasites but the same cytokines are also involved in severe malaria. We have shown that CTLA-4 expression during Plasmodium berghei malaria dampens the immune response. This strain provokes a pro-inflammatory immune response that is associated with the pathology of cerebral malaria. Accordingly a blockade of CTLA-4 during the blood-stage of P. berghei malaria leads to an exacerbation of disease. To analyze the effects of a CTLA-4 blockade in a malaria model which is not prone to immune pathology we employed P. yoelii infection. Blood-stage infection led to a rapid induction of CTLA-4 on T cells. Using the non-lethal P. yoelii strain Py17NL we found that a blockade of CTLA-4 resulted in an increased T cell activation and IFN-γ production, which was accompanied by a lower peak parasitemia and earlier parasite clearance. In contrast, blockade of CTLA-4 during infection with a P. yoelii strain exhibiting a higher parasitemia induced markedly increased serum-levels of TNF-α, which was associated with severe inflammation and reduced survival." @default.
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• W2011540282 date "2007-05-01" @default.
• W2011540282 modified "2023-10-16" @default.
• W2011540282 title "CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections" @default.
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• W2011540282 doi "https://doi.org/10.1016/j.micinf.2007.02.013" @default.
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