Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011541425> ?p ?o ?g. }
- W2011541425 endingPage "10716" @default.
- W2011541425 startingPage "10711" @default.
- W2011541425 abstract "IFN-γ is a major cytokine that is critical for host resistance to a broad range of intracellular pathogens. Production of IFN-γ by natural killer and T cells is initiated by the recognition of pathogens by Toll-like receptors (TLRs). In an experimental model of toxoplasmosis, we have identified the presence of a nonlymphoid source of IFN-γ that was particularly evident in the absence of TLR-mediated recognition of Toxoplasma gondii . Genetically altered mice lacking all lymphoid cells due to deficiencies in Recombination Activating Gene 2 and IL-2Rγ c genes also produced IFN-γ in response to the protozoan parasite. Flow-cytometry and morphological examinations of non-NK/non-T IFN-γ + cells identified neutrophils as the cell type capable of producing IFN-γ. Selective elimination of neutrophils in TLR11 −/− mice infected with the parasite resulted in acute susceptibility similar to that observed in IFN-γ–deficient mice. Similarly, Salmonella typhimurium infection of TLR-deficient mice induces the appearance of IFN-γ + neutrophils. Thus, neutrophils are a crucial source for IFN-γ that is required for TLR-independent host protection against intracellular pathogens." @default.
- W2011541425 created "2016-06-24" @default.
- W2011541425 creator A5002914011 @default.
- W2011541425 creator A5003057458 @default.
- W2011541425 creator A5017844537 @default.
- W2011541425 creator A5024392577 @default.
- W2011541425 creator A5050662237 @default.
- W2011541425 creator A5066271545 @default.
- W2011541425 creator A5084475433 @default.
- W2011541425 date "2013-06-10" @default.
- W2011541425 modified "2023-10-11" @default.
- W2011541425 title "TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens" @default.
- W2011541425 cites W1489852543 @default.
- W2011541425 cites W1568496347 @default.
- W2011541425 cites W1671057014 @default.
- W2011541425 cites W1768580582 @default.
- W2011541425 cites W1793115003 @default.
- W2011541425 cites W1925420621 @default.
- W2011541425 cites W1965836015 @default.
- W2011541425 cites W1968321644 @default.
- W2011541425 cites W1970279912 @default.
- W2011541425 cites W1972044265 @default.
- W2011541425 cites W1982070009 @default.
- W2011541425 cites W1982293312 @default.
- W2011541425 cites W1983422677 @default.
- W2011541425 cites W1985157285 @default.
- W2011541425 cites W1987410025 @default.
- W2011541425 cites W1998047654 @default.
- W2011541425 cites W2009101093 @default.
- W2011541425 cites W2009521410 @default.
- W2011541425 cites W2014133727 @default.
- W2011541425 cites W2014770545 @default.
- W2011541425 cites W2021361448 @default.
- W2011541425 cites W2036018864 @default.
- W2011541425 cites W2047084643 @default.
- W2011541425 cites W2050209022 @default.
- W2011541425 cites W2057698592 @default.
- W2011541425 cites W2058235794 @default.
- W2011541425 cites W2077602130 @default.
- W2011541425 cites W2084045789 @default.
- W2011541425 cites W2089025478 @default.
- W2011541425 cites W2094112441 @default.
- W2011541425 cites W2094197667 @default.
- W2011541425 cites W2096574830 @default.
- W2011541425 cites W2098907119 @default.
- W2011541425 cites W2099708557 @default.
- W2011541425 cites W2100196548 @default.
- W2011541425 cites W2109474336 @default.
- W2011541425 cites W2111200149 @default.
- W2011541425 cites W2111260918 @default.
- W2011541425 cites W2126464081 @default.
- W2011541425 cites W2134768631 @default.
- W2011541425 cites W2138698993 @default.
- W2011541425 cites W2143286868 @default.
- W2011541425 cites W2144885158 @default.
- W2011541425 cites W2147285844 @default.
- W2011541425 cites W2150759819 @default.
- W2011541425 doi "https://doi.org/10.1073/pnas.1307868110" @default.
- W2011541425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696766" @default.
- W2011541425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23754402" @default.
- W2011541425 hasPublicationYear "2013" @default.
- W2011541425 type Work @default.
- W2011541425 sameAs 2011541425 @default.
- W2011541425 citedByCount "100" @default.
- W2011541425 countsByYear W20115414252013 @default.
- W2011541425 countsByYear W20115414252014 @default.
- W2011541425 countsByYear W20115414252015 @default.
- W2011541425 countsByYear W20115414252016 @default.
- W2011541425 countsByYear W20115414252017 @default.
- W2011541425 countsByYear W20115414252018 @default.
- W2011541425 countsByYear W20115414252019 @default.
- W2011541425 countsByYear W20115414252020 @default.
- W2011541425 countsByYear W20115414252021 @default.
- W2011541425 countsByYear W20115414252022 @default.
- W2011541425 countsByYear W20115414252023 @default.
- W2011541425 crossrefType "journal-article" @default.
- W2011541425 hasAuthorship W2011541425A5002914011 @default.
- W2011541425 hasAuthorship W2011541425A5003057458 @default.
- W2011541425 hasAuthorship W2011541425A5017844537 @default.
- W2011541425 hasAuthorship W2011541425A5024392577 @default.
- W2011541425 hasAuthorship W2011541425A5050662237 @default.
- W2011541425 hasAuthorship W2011541425A5066271545 @default.
- W2011541425 hasAuthorship W2011541425A5084475433 @default.
- W2011541425 hasBestOaLocation W20115414251 @default.
- W2011541425 hasConcept C153726182 @default.
- W2011541425 hasConcept C159654299 @default.
- W2011541425 hasConcept C203014093 @default.
- W2011541425 hasConcept C2776178377 @default.
- W2011541425 hasConcept C2778128430 @default.
- W2011541425 hasConcept C2778690821 @default.
- W2011541425 hasConcept C2780841837 @default.
- W2011541425 hasConcept C553184892 @default.
- W2011541425 hasConcept C79879829 @default.
- W2011541425 hasConcept C86803240 @default.
- W2011541425 hasConcept C89423630 @default.
- W2011541425 hasConcept C95444343 @default.
- W2011541425 hasConceptScore W2011541425C153726182 @default.
- W2011541425 hasConceptScore W2011541425C159654299 @default.