FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011542688> ?p ?o ?g. }

• W2011542688 endingPage "378" @default.
• W2011542688 startingPage "373" @default.
• W2011542688 abstract "The lipoprotein lipase (LPL) gene has been investigated extensively in linkage studies and in studies of its association with lipid profiles and coronary artery disease (CAD), and this gene has also been reported to have an association with hypertension. In our previous linkage study on 148 Chinese hypertensive families, the regions at or near the LPL gene were found to be associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Thus the LPL gene is a logical candidate gene for involvement in the underlying cause of essential hypertension (EH). In the present study, we identified 22 sequence variants by directly sequencing 10 exons and flanking regions of the LPL gene, and investigated the occurrence of 3 of these variants, IVS4-214C>T, 7754C>A and S447X, in a case-control study including 501 normotensive (NT) subjects and 497 EH subjects. In males, the frequencies of the genotypes of each of the 3 variants did not differ significantly between the NT and EH groups. Among the EH group in females, ANCOVA revealed no significant difference in blood pressure levels according to the 7754C>A genotype. However, in female, the distribution of the 7754C>A genotype and the frequency of the A allele of 7754C>A differed significantly between the NT and EH groups (p =0.032 and p =0.027, respectively) with 0.78 (95% confidence interval (CI): 0.56 to 1.07; p =0.12) of odds ratio for the A allele. Moreover, haplotype analysis revealed that T-A-C and T-C-G haplotypes (in the order of IVS4-214C>T, 7754C>A and S447X) were statistically more frequent in the NT group than in the EH group in females and males, respectively. Our indivisual single nucleotide polymorphism (SNP) analysis did not provide substantial evidence of an association between polymorphisms in the LPL gene and hypertension status and/or blood pressure levels in this cohort, but the more powerful haplotypes analysis suggested an association between the LPL gene and hypertension. (Hypertens Res 2004; 27: 373-378)" @default.
• W2011542688 created "2016-06-24" @default.
• W2011542688 creator A5011688144 @default.
• W2011542688 creator A5020362013 @default.
• W2011542688 creator A5020779247 @default.
• W2011542688 creator A5029900952 @default.
• W2011542688 creator A5030326080 @default.
• W2011542688 creator A5053677811 @default.
• W2011542688 creator A5055763642 @default.
• W2011542688 date "2004-01-01" @default.
• W2011542688 modified "2023-10-14" @default.
• W2011542688 title "Lipoprotein Lipase Gene Polymorphisms and Blood Pressure Levels in the Northern Chinese Han Population" @default.
• W2011542688 cites W1508985588 @default.
• W2011542688 cites W1583476286 @default.
• W2011542688 cites W1598899303 @default.
• W2011542688 cites W1711580613 @default.
• W2011542688 cites W1964901903 @default.
• W2011542688 cites W1969673534 @default.
• W2011542688 cites W1994834210 @default.
• W2011542688 cites W2002273927 @default.
• W2011542688 cites W2011468836 @default.
• W2011542688 cites W2013180694 @default.
• W2011542688 cites W2013264580 @default.
• W2011542688 cites W2014232335 @default.
• W2011542688 cites W2020580829 @default.
• W2011542688 cites W2021535444 @default.
• W2011542688 cites W2022028563 @default.
• W2011542688 cites W2034035903 @default.
• W2011542688 cites W2036931155 @default.
• W2011542688 cites W2038060058 @default.
• W2011542688 cites W2046062863 @default.
• W2011542688 cites W2067760644 @default.
• W2011542688 cites W2073264424 @default.
• W2011542688 cites W2081259110 @default.
• W2011542688 cites W2095046560 @default.
• W2011542688 cites W2096298361 @default.
• W2011542688 cites W2127141734 @default.
• W2011542688 cites W2129559300 @default.
• W2011542688 cites W2163387184 @default.
• W2011542688 cites W2164265846 @default.
• W2011542688 cites W2166185432 @default.
• W2011542688 cites W2314080775 @default.
• W2011542688 cites W2327648160 @default.
• W2011542688 cites W2995201542 @default.
• W2011542688 cites W4244586896 @default.
• W2011542688 doi "https://doi.org/10.1291/hypres.27.373" @default.
• W2011542688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15253101" @default.
• W2011542688 hasPublicationYear "2004" @default.
• W2011542688 type Work @default.
• W2011542688 sameAs 2011542688 @default.
• W2011542688 citedByCount "16" @default.
• W2011542688 countsByYear W20115426882013 @default.
• W2011542688 countsByYear W20115426882014 @default.
• W2011542688 countsByYear W20115426882017 @default.
• W2011542688 countsByYear W20115426882020 @default.
• W2011542688 countsByYear W20115426882022 @default.
• W2011542688 countsByYear W20115426882023 @default.
• W2011542688 crossrefType "journal-article" @default.
• W2011542688 hasAuthorship W2011542688A5011688144 @default.
• W2011542688 hasAuthorship W2011542688A5020362013 @default.
• W2011542688 hasAuthorship W2011542688A5020779247 @default.
• W2011542688 hasAuthorship W2011542688A5029900952 @default.
• W2011542688 hasAuthorship W2011542688A5030326080 @default.
• W2011542688 hasAuthorship W2011542688A5053677811 @default.
• W2011542688 hasAuthorship W2011542688A5055763642 @default.
• W2011542688 hasBestOaLocation W20115426881 @default.
• W2011542688 hasConcept C104317684 @default.
• W2011542688 hasConcept C126322002 @default.
• W2011542688 hasConcept C134018914 @default.
• W2011542688 hasConcept C135763542 @default.
• W2011542688 hasConcept C156957248 @default.
• W2011542688 hasConcept C171089720 @default.
• W2011542688 hasConcept C180754005 @default.
• W2011542688 hasConcept C197754878 @default.
• W2011542688 hasConcept C2777097880 @default.
• W2011542688 hasConcept C37463918 @default.
• W2011542688 hasConcept C54355233 @default.
• W2011542688 hasConcept C69991583 @default.
• W2011542688 hasConcept C71924100 @default.
• W2011542688 hasConcept C84393581 @default.
• W2011542688 hasConcept C86803240 @default.
• W2011542688 hasConcept C94879076 @default.
• W2011542688 hasConceptScore W2011542688C104317684 @default.
• W2011542688 hasConceptScore W2011542688C126322002 @default.
• W2011542688 hasConceptScore W2011542688C134018914 @default.
• W2011542688 hasConceptScore W2011542688C135763542 @default.
• W2011542688 hasConceptScore W2011542688C156957248 @default.
• W2011542688 hasConceptScore W2011542688C171089720 @default.
• W2011542688 hasConceptScore W2011542688C180754005 @default.
• W2011542688 hasConceptScore W2011542688C197754878 @default.
• W2011542688 hasConceptScore W2011542688C2777097880 @default.
• W2011542688 hasConceptScore W2011542688C37463918 @default.
• W2011542688 hasConceptScore W2011542688C54355233 @default.
• W2011542688 hasConceptScore W2011542688C69991583 @default.
• W2011542688 hasConceptScore W2011542688C71924100 @default.
• W2011542688 hasConceptScore W2011542688C84393581 @default.
• W2011542688 hasConceptScore W2011542688C86803240 @default.
• W2011542688 hasConceptScore W2011542688C94879076 @default.

• next