FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011551149> ?p ?o ?g. }

• W2011551149 endingPage "438" @default.
• W2011551149 startingPage "426" @default.
• W2011551149 abstract "TRPA1, a member of the transient receptor potential (TRP) family of cation channels, has mainly been characterized as a chemosensory protein in neuronal cells. TRPA1 is activated by toxic or irritating volatile agents like allyl isothiocyanate (AITC), tear gas, formalin, or cigarette smoke. To date, little is known about a function of TRPA1 in non-neuronal cells in the respiratory system and even less regarding a possible role in cancer biology. Here, we show that TRPA1 is expressed in a panel of human small cell lung cancer (SCLC) cell lines. Of note, TRPA1 mRNA was also significantly higher expressed in tumor samples of SCLC patients as compared to non-SCLC tumor samples or non-malignant lung tissue. Stimulation of SCLC cells with AITC led to a rise of the intracellular calcium concentration. This calcium response was inhibited by TRPA1 antagonists. Furthermore, AITC or formalin stimulated ERK1/2 in TRPA1-expressing HEK293 cells and in SCLC cells via a Src- and calcium-dependent mechanism. More importantly, TRPA1 activation in SCLC cells prevented apoptosis induced by serum starvation and thus promoted cell survival, an effect which could be blocked by inhibition of TRPA1 or ERK1/2. Vice versa, down-regulation of TRPA1 severely impaired anchorage-independent growth of SCLC cells. Since TRPA1 appears to play a pivotal role for cell survival in SCLC cells we propose that this channel could represent a promising target for therapeutic interventions. Furthermore, our data suggest that exogenous, inhalable activators of TRPA1 could be able to exert tumor promoting effects in SCLC cells." @default.
• W2011551149 created "2016-06-24" @default.
• W2011551149 creator A5019603584 @default.
• W2011551149 creator A5030952942 @default.
• W2011551149 creator A5036004370 @default.
• W2011551149 creator A5040695029 @default.
• W2011551149 creator A5065854689 @default.
• W2011551149 creator A5077066668 @default.
• W2011551149 date "2013-02-01" @default.
• W2011551149 modified "2023-10-13" @default.
• W2011551149 title "Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells" @default.
• W2011551149 cites W1965153645 @default.
• W2011551149 cites W1970878584 @default.
• W2011551149 cites W1971388165 @default.
• W2011551149 cites W1973007396 @default.
• W2011551149 cites W1973619060 @default.
• W2011551149 cites W1981057134 @default.
• W2011551149 cites W1983127589 @default.
• W2011551149 cites W1985914288 @default.
• W2011551149 cites W1987149979 @default.
• W2011551149 cites W1993207284 @default.
• W2011551149 cites W1997828131 @default.
• W2011551149 cites W1998647619 @default.
• W2011551149 cites W1999521736 @default.
• W2011551149 cites W2004234324 @default.
• W2011551149 cites W2006423053 @default.
• W2011551149 cites W2006908806 @default.
• W2011551149 cites W2010856639 @default.
• W2011551149 cites W2011350367 @default.
• W2011551149 cites W2012402537 @default.
• W2011551149 cites W2014185236 @default.
• W2011551149 cites W2023420445 @default.
• W2011551149 cites W2035257142 @default.
• W2011551149 cites W2037337146 @default.
• W2011551149 cites W2039246411 @default.
• W2011551149 cites W2043172711 @default.
• W2011551149 cites W2046383193 @default.
• W2011551149 cites W2050279035 @default.
• W2011551149 cites W2052400079 @default.
• W2011551149 cites W2056674840 @default.
• W2011551149 cites W2068927073 @default.
• W2011551149 cites W2075308422 @default.
• W2011551149 cites W2075613967 @default.
• W2011551149 cites W2077744054 @default.
• W2011551149 cites W2079711255 @default.
• W2011551149 cites W2082832752 @default.
• W2011551149 cites W2086395469 @default.
• W2011551149 cites W2090469880 @default.
• W2011551149 cites W2096225389 @default.
• W2011551149 cites W2109879418 @default.
• W2011551149 cites W2111972883 @default.
• W2011551149 cites W2119835285 @default.
• W2011551149 cites W2120229762 @default.
• W2011551149 cites W2126181026 @default.
• W2011551149 cites W2145505569 @default.
• W2011551149 cites W2161063110 @default.
• W2011551149 cites W2162478991 @default.
• W2011551149 cites W2164073806 @default.
• W2011551149 cites W2327782821 @default.
• W2011551149 cites W2726250309 @default.
• W2011551149 cites W4248805815 @default.
• W2011551149 cites W56214437 @default.
• W2011551149 doi "https://doi.org/10.1016/j.bcp.2012.11.019" @default.
• W2011551149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23219522" @default.
• W2011551149 hasPublicationYear "2013" @default.
• W2011551149 type Work @default.
• W2011551149 sameAs 2011551149 @default.
• W2011551149 citedByCount "55" @default.
• W2011551149 countsByYear W20115511492013 @default.
• W2011551149 countsByYear W20115511492014 @default.
• W2011551149 countsByYear W20115511492015 @default.
• W2011551149 countsByYear W20115511492016 @default.
• W2011551149 countsByYear W20115511492017 @default.
• W2011551149 countsByYear W20115511492018 @default.
• W2011551149 countsByYear W20115511492019 @default.
• W2011551149 countsByYear W20115511492020 @default.
• W2011551149 countsByYear W20115511492021 @default.
• W2011551149 countsByYear W20115511492022 @default.
• W2011551149 countsByYear W20115511492023 @default.
• W2011551149 crossrefType "journal-article" @default.
• W2011551149 hasAuthorship W2011551149A5019603584 @default.
• W2011551149 hasAuthorship W2011551149A5030952942 @default.
• W2011551149 hasAuthorship W2011551149A5036004370 @default.
• W2011551149 hasAuthorship W2011551149A5040695029 @default.
• W2011551149 hasAuthorship W2011551149A5065854689 @default.
• W2011551149 hasAuthorship W2011551149A5077066668 @default.
• W2011551149 hasConcept C121608353 @default.
• W2011551149 hasConcept C126322002 @default.
• W2011551149 hasConcept C134018914 @default.
• W2011551149 hasConcept C1491633281 @default.
• W2011551149 hasConcept C155164980 @default.
• W2011551149 hasConcept C170493617 @default.
• W2011551149 hasConcept C178790620 @default.
• W2011551149 hasConcept C181080969 @default.
• W2011551149 hasConcept C185592680 @default.
• W2011551149 hasConcept C190283241 @default.
• W2011551149 hasConcept C24998067 @default.
• W2011551149 hasConcept C2777103848 @default.

• next