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- W2011562671 abstract "Here, the authors show that scratching the cutaneous receptive field of primate spinothalamic neurons produces inhibition during histamine-evoked itchiness, but not during spontaneous activity or activity evoked by pain. This suggests that the inhibition of itch by scratching is state-dependent in the spinal cord. Itch is relieved by scratching, but the neural mechanisms that are responsible for this are unknown. Spinothalamic tract (STT) neurons respond to itch-producing agents and transmit pruritic information to the brain. We observed that scratching the cutaneous receptive field of primate STT neurons produced inhibition during histamine-evoked activity but not during spontaneous activity or activity evoked by a painful stimulus, suggesting that scratching inhibits the transmission of itch in the spinal cord in a state-dependent manner." @default.
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- W2011562671 date "2009-04-06" @default.
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- W2011562671 title "Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons" @default.
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- W2011562671 doi "https://doi.org/10.1038/nn.2292" @default.
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