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• W2011567013 abstract "Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction and maintenance phases. Testing the hypothesis that the mechanism of LTP maintenance stores information requires reversing this mechanism in vivo and finding out whether long-term stored information is lost. This was not previously possible. Recently however, persistent phosphorylation by the atypical protein kinase C isoform, protein kinase Mzeta (PKMz), has been found to maintain late LTP in hippocampal slices. Here we show that a cell-permeable PKMz inhibitor, injected in the rat hippocampus, both reverses LTP maintenance in vivo and produces persistent loss of 1-day-old spatial information. Thus, the mechanism maintaining LTP sustains spatial memory." @default.
• W2011567013 created "2016-06-24" @default.
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• W2011567013 date "2006-08-25" @default.
• W2011567013 modified "2023-10-01" @default.
• W2011567013 title "Storage of Spatial Information by the Maintenance Mechanism of LTP" @default.
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• W2011567013 doi "https://doi.org/10.1126/science.1128657" @default.
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