Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011567260> ?p ?o ?g. }
- W2011567260 endingPage "53" @default.
- W2011567260 startingPage "44" @default.
- W2011567260 abstract "Towards understanding the IGF system during cancer growth and progression, progressive prostate cancer models, such as SV40 large T antigen immortalized human prostate epithelial cells (P69, M2182, M2205, and M12) and LNCaP sublines (C4, C4-2, and C4-2B4), were used. IGF-II mRNA levels progressively increase as prostate cancer cells become more tumorigenic and metastatic, suggesting that IGF-II contributes in part to prostate cancer progression. The role of IGF-II in cancer cell growth was evaluated in LNCaP, PC3, and M12 prostate cancer cell lines and MCF-7 breast cancer cell line by ribozyme/antisense strategies which were previously shown to suppress endogenous IGF-II expression and cell growth in PC-3 cells [Xu et al., Endocrinol 140 (1999) 2134]. Retroviral mediated transient expression of IGF-II-specific ribozyme (RZ) caused extensive cell death. In stably cloned cell lines, both RZ and mutant ribozyme (MRZ) inhibited cancer cell growth, suggesting that antisense effects of MRZ may be sufficient for cell growth inhibition. These results confirm an important role of IGF-II in cancer cell growth and progression, and support further development of gene therapy targeting IGF-II." @default.
- W2011567260 created "2016-06-24" @default.
- W2011567260 creator A5001190119 @default.
- W2011567260 creator A5029893522 @default.
- W2011567260 creator A5030321109 @default.
- W2011567260 creator A5042233884 @default.
- W2011567260 creator A5048287446 @default.
- W2011567260 creator A5053018243 @default.
- W2011567260 creator A5074350469 @default.
- W2011567260 creator A5080662019 @default.
- W2011567260 creator A5083812488 @default.
- W2011567260 date "2003-02-01" @default.
- W2011567260 modified "2023-09-26" @default.
- W2011567260 title "The role of insulin-like growth factor-II in cancer growth and progression evidenced by the use of ribozymes and prostate cancer progression models" @default.
- W2011567260 cites W1982841574 @default.
- W2011567260 cites W1986731330 @default.
- W2011567260 cites W1990359489 @default.
- W2011567260 cites W1993996978 @default.
- W2011567260 cites W2001479083 @default.
- W2011567260 cites W2015277221 @default.
- W2011567260 cites W2017757468 @default.
- W2011567260 cites W2018342641 @default.
- W2011567260 cites W2039033693 @default.
- W2011567260 cites W2064166253 @default.
- W2011567260 cites W2070284356 @default.
- W2011567260 cites W2081075932 @default.
- W2011567260 cites W2092209832 @default.
- W2011567260 cites W2094303934 @default.
- W2011567260 cites W2122379933 @default.
- W2011567260 cites W2160466713 @default.
- W2011567260 cites W4232211663 @default.
- W2011567260 cites W4234019287 @default.
- W2011567260 cites W4237186569 @default.
- W2011567260 cites W4243083151 @default.
- W2011567260 cites W4247693029 @default.
- W2011567260 cites W4249286641 @default.
- W2011567260 cites W4250395623 @default.
- W2011567260 cites W4250413823 @default.
- W2011567260 cites W4255309247 @default.
- W2011567260 cites W4255736139 @default.
- W2011567260 cites W4294216491 @default.
- W2011567260 doi "https://doi.org/10.1016/s1096-6374(02)00121-1" @default.
- W2011567260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12550081" @default.
- W2011567260 hasPublicationYear "2003" @default.
- W2011567260 type Work @default.
- W2011567260 sameAs 2011567260 @default.
- W2011567260 citedByCount "25" @default.
- W2011567260 countsByYear W20115672602012 @default.
- W2011567260 countsByYear W20115672602014 @default.
- W2011567260 countsByYear W20115672602016 @default.
- W2011567260 crossrefType "journal-article" @default.
- W2011567260 hasAuthorship W2011567260A5001190119 @default.
- W2011567260 hasAuthorship W2011567260A5029893522 @default.
- W2011567260 hasAuthorship W2011567260A5030321109 @default.
- W2011567260 hasAuthorship W2011567260A5042233884 @default.
- W2011567260 hasAuthorship W2011567260A5048287446 @default.
- W2011567260 hasAuthorship W2011567260A5053018243 @default.
- W2011567260 hasAuthorship W2011567260A5074350469 @default.
- W2011567260 hasAuthorship W2011567260A5080662019 @default.
- W2011567260 hasAuthorship W2011567260A5083812488 @default.
- W2011567260 hasConcept C104317684 @default.
- W2011567260 hasConcept C121608353 @default.
- W2011567260 hasConcept C126322002 @default.
- W2011567260 hasConcept C170493617 @default.
- W2011567260 hasConcept C2775960820 @default.
- W2011567260 hasConcept C2779256057 @default.
- W2011567260 hasConcept C2779723316 @default.
- W2011567260 hasConcept C2780192828 @default.
- W2011567260 hasConcept C502942594 @default.
- W2011567260 hasConcept C54355233 @default.
- W2011567260 hasConcept C62112901 @default.
- W2011567260 hasConcept C67705224 @default.
- W2011567260 hasConcept C71924100 @default.
- W2011567260 hasConcept C76346623 @default.
- W2011567260 hasConcept C81885089 @default.
- W2011567260 hasConcept C86803240 @default.
- W2011567260 hasConcept C96232424 @default.
- W2011567260 hasConceptScore W2011567260C104317684 @default.
- W2011567260 hasConceptScore W2011567260C121608353 @default.
- W2011567260 hasConceptScore W2011567260C126322002 @default.
- W2011567260 hasConceptScore W2011567260C170493617 @default.
- W2011567260 hasConceptScore W2011567260C2775960820 @default.
- W2011567260 hasConceptScore W2011567260C2779256057 @default.
- W2011567260 hasConceptScore W2011567260C2779723316 @default.
- W2011567260 hasConceptScore W2011567260C2780192828 @default.
- W2011567260 hasConceptScore W2011567260C502942594 @default.
- W2011567260 hasConceptScore W2011567260C54355233 @default.
- W2011567260 hasConceptScore W2011567260C62112901 @default.
- W2011567260 hasConceptScore W2011567260C67705224 @default.
- W2011567260 hasConceptScore W2011567260C71924100 @default.
- W2011567260 hasConceptScore W2011567260C76346623 @default.
- W2011567260 hasConceptScore W2011567260C81885089 @default.
- W2011567260 hasConceptScore W2011567260C86803240 @default.
- W2011567260 hasConceptScore W2011567260C96232424 @default.
- W2011567260 hasIssue "1" @default.
- W2011567260 hasLocation W20115672601 @default.
- W2011567260 hasLocation W20115672602 @default.
- W2011567260 hasOpenAccess W2011567260 @default.