FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011570206> ?p ?o ?g. }

• W2011570206 endingPage "70" @default.
• W2011570206 startingPage "69" @default.
• W2011570206 abstract "Purpose: Early infantile epileptic encephaiopathy with suppression burst (EIEE) is characterized by an EEG pattern that alternates between an irregular mixture of spikes and waves and almost flat activity, each lasting from 1 to several seconds. This report presents a case characterized by lidocaine dependence, intractable hyponatremia, and an EEG pattern that alternates between extremely long suppression and short burst. In addition, the possible pathomechanism of the suppression is discussed. Case report; We examined a female patient born at term by normal delivery, who had a birth weight of 2,546 g and a head circumference of 33 cm. She did not present with asphyxia but hardly cried artd was unable to breast feed. Blood studies showed persistent hyponatremia ranging between 120 and 130 mEq/L. Endocrinological examinations disclosed no abnormalities. Despite NaCl loading and water restriction, the persistent hyponatremia did not show improvement. Tube feeding was started, but her activity and responsiveness remained poor. One month after birth, clonic seizures were observed in the face and limbs. Phenobarbital and diazepam were only transiently effective. Valproate and vitamin B6 were ineffective. Ten days after the onset of seizures, the patient was transferred to our hospital. On admission, she demonstrated repeated seizure activity every 1 to 2 minutes, lasting 10 to 15 seconds. Movement consisted of a series of tonic extension of the upper limbs, head turning toward the right, and clonic right hemiconvulsion. The head circumference increased to 41 cm at one and half month. The EEG showed burst activity during the seizure movements and suppressed flat activity during the interictal phase lasting I to 2 minutes. There were no spontaneous movements other than seizure and no response even to noxious stimuli. After starting intravenous lidocaine administration, the seizure activity improved and completely disappeared within 8 hours. The next day, the patient was able to cry and her hyponatremia improved. Three days after starting lidocaine, she was able to breast feed and the duration of the suppression phase in the EEG decreased to less than 10 seconds. Within several hours of ceasing lidocaine administration, the seizure movements reappeared and the EEG showed an extremely suppressed pattern. Within a several hours after restarting lidocaine, seizure movements disappeared, and the EEG improved. Based on these observations, we continued intravenous administration of lidocaine at a serum concentration of approximately 0.5 y/ml. Thereafter, head circumference improved, the EEG changed from a suppression burst pattern to an irregular slow wave pattern, and the patient showed more development, Nevertheless, an MRI revealed progressive cerebral atrophy. We changed from intravenous administration of lidocaine to the viscous lidocaine to enable administration through a gastric tube. Given the pharmacological mechanisms of lidocaine as a sodium channel blocker, we speculate that our patient had a sodium channel dysfunction that caused an overflow of sodium from the extracellular apace into neurons and other excitable cells. This hypothesis could explain the characteristic findings in our patient including intractable hyponatremia, extremely suppressed EEG, and subacute megalencephaly. We believe that this mechanisms merits further consideration." @default.
• W2011570206 created "2016-06-24" @default.
• W2011570206 creator A5008013959 @default.
• W2011570206 creator A5068324330 @default.
• W2011570206 creator A5086093597 @default.
• W2011570206 creator A5090901552 @default.
• W2011570206 date "2000-09-01" @default.
• W2011570206 modified "2023-10-04" @default.
• W2011570206 title "Lidocaine-Dependent Early Infantile Epileptic Encephalopathy with Hyponatremia and Highly Suppressed EEG" @default.
• W2011570206 doi "https://doi.org/10.1111/j.1528-1157.2000.tb02270.x" @default.
• W2011570206 hasPublicationYear "2000" @default.
• W2011570206 type Work @default.
• W2011570206 sameAs 2011570206 @default.
• W2011570206 citedByCount "0" @default.
• W2011570206 crossrefType "journal-article" @default.
• W2011570206 hasAuthorship W2011570206A5008013959 @default.
• W2011570206 hasAuthorship W2011570206A5068324330 @default.
• W2011570206 hasAuthorship W2011570206A5086093597 @default.
• W2011570206 hasAuthorship W2011570206A5090901552 @default.
• W2011570206 hasBestOaLocation W20115702061 @default.
• W2011570206 hasConcept C118552586 @default.
• W2011570206 hasConcept C126322002 @default.
• W2011570206 hasConcept C187212893 @default.
• W2011570206 hasConcept C2776175493 @default.
• W2011570206 hasConcept C2776703092 @default.
• W2011570206 hasConcept C2777341932 @default.
• W2011570206 hasConcept C2778186239 @default.
• W2011570206 hasConcept C2778621155 @default.
• W2011570206 hasConcept C2780149897 @default.
• W2011570206 hasConcept C42219234 @default.
• W2011570206 hasConcept C522805319 @default.
• W2011570206 hasConcept C71924100 @default.
• W2011570206 hasConceptScore W2011570206C118552586 @default.
• W2011570206 hasConceptScore W2011570206C126322002 @default.
• W2011570206 hasConceptScore W2011570206C187212893 @default.
• W2011570206 hasConceptScore W2011570206C2776175493 @default.
• W2011570206 hasConceptScore W2011570206C2776703092 @default.
• W2011570206 hasConceptScore W2011570206C2777341932 @default.
• W2011570206 hasConceptScore W2011570206C2778186239 @default.
• W2011570206 hasConceptScore W2011570206C2778621155 @default.
• W2011570206 hasConceptScore W2011570206C2780149897 @default.
• W2011570206 hasConceptScore W2011570206C42219234 @default.
• W2011570206 hasConceptScore W2011570206C522805319 @default.
• W2011570206 hasConceptScore W2011570206C71924100 @default.
• W2011570206 hasIssue "s9" @default.
• W2011570206 hasLocation W20115702061 @default.
• W2011570206 hasOpenAccess W2011570206 @default.
• W2011570206 hasPrimaryLocation W20115702061 @default.
• W2011570206 hasRelatedWork W1975614538 @default.
• W2011570206 hasRelatedWork W1986956795 @default.
• W2011570206 hasRelatedWork W1995679204 @default.
• W2011570206 hasRelatedWork W2011570206 @default.
• W2011570206 hasRelatedWork W2017055595 @default.
• W2011570206 hasRelatedWork W2023674423 @default.
• W2011570206 hasRelatedWork W2079780342 @default.
• W2011570206 hasRelatedWork W2241876992 @default.
• W2011570206 hasRelatedWork W2360573189 @default.
• W2011570206 hasRelatedWork W2417501204 @default.
• W2011570206 hasVolume "41" @default.
• W2011570206 isParatext "false" @default.
• W2011570206 isRetracted "false" @default.
• W2011570206 magId "2011570206" @default.
• W2011570206 workType "article" @default.