FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011570504> ?p ?o ?g. }

• W2011570504 endingPage "571" @default.
• W2011570504 startingPage "561" @default.
• W2011570504 abstract "The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses is superior to histopathology for reflecting distinct biological groups, predicting outcomes and guiding therapy decisions has yet to be determined. Epigenome-wide DNA methylation analysis, using a platform which also allows the detection of copy-number aberrations, was performed in a cohort of 228 patients with anaplastic gliomas (astrocytomas, oligoastrocytomas, and oligodendrogliomas), including 115 patients of the NOA-04 trial. We further compared these tumors with a group of 55 glioblastomas. Unsupervised clustering of DNA methylation patterns revealed two main groups correlated with IDH status: CpG island methylator phenotype (CIMP) positive (77.5 %) or negative (22.5 %). CIMPpos (IDH mutant) tumors showed a further separation based on copy-number status of chromosome arms 1p and 19q. CIMPneg (IDH wild type) tumors showed hallmark copy-number alterations of glioblastomas, and clustered together with CIMPneg glioblastomas without forming separate groups based on WHO grade. Notably, there was no molecular evidence for a distinct biological entity representing anaplastic oligoastrocytoma. Tumor classification based on CIMP and 1p/19q status was significantly associated with survival, allowing a better prediction of outcome than the current histopathological classification: patients with CIMPpos tumors with 1p/19q codeletion (CIMP-codel) had the best prognosis, followed by patients with CIMPpos tumors but intact 1p/19q status (CIMP-non-codel). Patients with CIMPneg anaplastic gliomas (GBM-like) had the worst prognosis. Collectively, our data suggest that anaplastic gliomas can be grouped by IDH and 1p/19q status into three molecular groups that show clear links to underlying biology and a significant association with clinical outcome in a prospective trial cohort." @default.
• W2011570504 created "2016-06-24" @default.
• W2011570504 creator A5001237705 @default.
• W2011570504 creator A5010036887 @default.
• W2011570504 creator A5010582324 @default.
• W2011570504 creator A5014073957 @default.
• W2011570504 creator A5014129073 @default.
• W2011570504 creator A5015267609 @default.
• W2011570504 creator A5022108122 @default.
• W2011570504 creator A5025477516 @default.
• W2011570504 creator A5027116276 @default.
• W2011570504 creator A5038035447 @default.
• W2011570504 creator A5039263372 @default.
• W2011570504 creator A5039647180 @default.
• W2011570504 creator A5039985608 @default.
• W2011570504 creator A5041096535 @default.
• W2011570504 creator A5044206440 @default.
• W2011570504 creator A5050894746 @default.
• W2011570504 creator A5052657395 @default.
• W2011570504 creator A5064288807 @default.
• W2011570504 creator A5064456190 @default.
• W2011570504 creator A5064778456 @default.
• W2011570504 creator A5074018145 @default.
• W2011570504 creator A5080482957 @default.
• W2011570504 creator A5084473005 @default.
• W2011570504 creator A5090815387 @default.
• W2011570504 creator A5091359885 @default.
• W2011570504 date "2014-07-10" @default.
• W2011570504 modified "2023-10-10" @default.
• W2011570504 title "Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma" @default.
• W2011570504 cites W1970547133 @default.
• W2011570504 cites W1982088425 @default.
• W2011570504 cites W1986009297 @default.
• W2011570504 cites W1988756388 @default.
• W2011570504 cites W1995675594 @default.
• W2011570504 cites W1996908572 @default.
• W2011570504 cites W2013816626 @default.
• W2011570504 cites W2022064821 @default.
• W2011570504 cites W2033130827 @default.
• W2011570504 cites W2040827479 @default.
• W2011570504 cites W2046029490 @default.
• W2011570504 cites W2057308377 @default.
• W2011570504 cites W2066343654 @default.
• W2011570504 cites W2100795816 @default.
• W2011570504 cites W2105528101 @default.
• W2011570504 cites W2109816625 @default.
• W2011570504 cites W2114551767 @default.
• W2011570504 cites W2126817554 @default.
• W2011570504 cites W2131117209 @default.
• W2011570504 cites W2133865472 @default.
• W2011570504 cites W2140892567 @default.
• W2011570504 cites W2141431050 @default.
• W2011570504 cites W2141713919 @default.
• W2011570504 cites W2145489645 @default.
• W2011570504 cites W2147013683 @default.
• W2011570504 cites W2154526619 @default.
• W2011570504 cites W2155677253 @default.
• W2011570504 cites W2158233796 @default.
• W2011570504 cites W2158501128 @default.
• W2011570504 cites W2160382843 @default.
• W2011570504 cites W2161289668 @default.
• W2011570504 cites W2164890947 @default.
• W2011570504 cites W2171418517 @default.
• W2011570504 doi "https://doi.org/10.1007/s00401-014-1315-x" @default.
• W2011570504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25008768" @default.
• W2011570504 hasPublicationYear "2014" @default.
• W2011570504 type Work @default.
• W2011570504 sameAs 2011570504 @default.
• W2011570504 citedByCount "168" @default.
• W2011570504 countsByYear W20115705042014 @default.
• W2011570504 countsByYear W20115705042015 @default.
• W2011570504 countsByYear W20115705042016 @default.
• W2011570504 countsByYear W20115705042017 @default.
• W2011570504 countsByYear W20115705042018 @default.
• W2011570504 countsByYear W20115705042019 @default.
• W2011570504 countsByYear W20115705042020 @default.
• W2011570504 countsByYear W20115705042021 @default.
• W2011570504 countsByYear W20115705042022 @default.
• W2011570504 countsByYear W20115705042023 @default.
• W2011570504 crossrefType "journal-article" @default.
• W2011570504 hasAuthorship W2011570504A5001237705 @default.
• W2011570504 hasAuthorship W2011570504A5010036887 @default.
• W2011570504 hasAuthorship W2011570504A5010582324 @default.
• W2011570504 hasAuthorship W2011570504A5014073957 @default.
• W2011570504 hasAuthorship W2011570504A5014129073 @default.
• W2011570504 hasAuthorship W2011570504A5015267609 @default.
• W2011570504 hasAuthorship W2011570504A5022108122 @default.
• W2011570504 hasAuthorship W2011570504A5025477516 @default.
• W2011570504 hasAuthorship W2011570504A5027116276 @default.
• W2011570504 hasAuthorship W2011570504A5038035447 @default.
• W2011570504 hasAuthorship W2011570504A5039263372 @default.
• W2011570504 hasAuthorship W2011570504A5039647180 @default.
• W2011570504 hasAuthorship W2011570504A5039985608 @default.
• W2011570504 hasAuthorship W2011570504A5041096535 @default.
• W2011570504 hasAuthorship W2011570504A5044206440 @default.
• W2011570504 hasAuthorship W2011570504A5050894746 @default.
• W2011570504 hasAuthorship W2011570504A5052657395 @default.
• W2011570504 hasAuthorship W2011570504A5064288807 @default.

• next