Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011573190> ?p ?o ?g. }
- W2011573190 abstract "Flaxseed (FS) is a dietary supplement known for its antioxidant and anti-inflammatory properties. Radiation exposure of lung tissues occurs either when given therapeutically to treat intrathoracic malignancies or incidentally, such as in the case of exposure from inhaled radioisotopes released after the detonation of a radiological dispersion devise (RDD). Such exposure is associated with pulmonary inflammation, oxidative tissue damage and irreversible lung fibrosis. We previously reported that dietary FS prevents pneumonopathy in a rodent model of thoracic X-ray radiation therapy (XRT). However, flaxseed's therapeutic usefulness in mitigating radiation effects post-exposure has never been evaluated.We evaluated the effects of a 10%FS or isocaloric control diet given to mice (C57/BL6) in 2 separate experiments (n = 15-25 mice/group) on 0, 2, 4, 6 weeks post a single dose 13.5 Gy thoracic XRT and compared it to an established radiation-protective diet given preventively, starting at 3 weeks prior to XRT. Lungs were evaluated four months post-XRT for blood oxygenation levels, inflammation and fibrosis.Irradiated mice fed a 0%FS diet had a 4-month survival rate of 40% as compared to 70-88% survival in irradiated FS-fed mouse groups. Additionally, all irradiated FS-fed mice had decreased fibrosis compared to those fed 0%FS. Lung OH-Proline content ranged from 96.5 ± 7.1 to 110.2 ± 7.7 μg/ml (Mean ± SEM) in all irradiated FS-fed mouse groups, as compared to 138 ± 10.8 μg/ml for mice on 0%FS. Concomitantly, bronchoalveolar lavage (BAL) protein and weight loss associated with radiation cachexia was significantly decreased in all FS-fed groups. Inflammatory cell influx to lungs also decreased significantly except when FS diet was delayed by 4 and 6 weeks post XRT. All FS-fed mice (irradiated or not), maintained a higher blood oxygenation level as compared to mice on 0%FS. Similarly, multiplex cytokine analysis in the BAL fluid revealed a significant decrease of specific inflammatory cytokines in FS-fed mice.Dietary FS given post-XRT mitigates radiation effects by decreasing pulmonary fibrosis, inflammation, cytokine secretion and lung damage while enhancing mouse survival. Dietary supplementation of FS may be a useful adjuvant treatment mitigating adverse effects of radiation in individuals exposed to inhaled radioisotopes or incidental radiation." @default.
- W2011573190 created "2016-06-24" @default.
- W2011573190 creator A5008260288 @default.
- W2011573190 creator A5016873527 @default.
- W2011573190 creator A5017021744 @default.
- W2011573190 creator A5026614969 @default.
- W2011573190 creator A5055734763 @default.
- W2011573190 creator A5062258585 @default.
- W2011573190 creator A5065576440 @default.
- W2011573190 creator A5070392597 @default.
- W2011573190 creator A5076092861 @default.
- W2011573190 creator A5080849169 @default.
- W2011573190 date "2011-06-24" @default.
- W2011573190 modified "2023-10-01" @default.
- W2011573190 title "Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice" @default.
- W2011573190 cites W1942344155 @default.
- W2011573190 cites W1971938662 @default.
- W2011573190 cites W1981413744 @default.
- W2011573190 cites W1987444332 @default.
- W2011573190 cites W1993268153 @default.
- W2011573190 cites W1996154720 @default.
- W2011573190 cites W2004660935 @default.
- W2011573190 cites W2007292828 @default.
- W2011573190 cites W2008174687 @default.
- W2011573190 cites W2016145760 @default.
- W2011573190 cites W2018165119 @default.
- W2011573190 cites W2025112087 @default.
- W2011573190 cites W2031150257 @default.
- W2011573190 cites W2034462747 @default.
- W2011573190 cites W2036184396 @default.
- W2011573190 cites W2041559070 @default.
- W2011573190 cites W2044910514 @default.
- W2011573190 cites W2046053045 @default.
- W2011573190 cites W2051695868 @default.
- W2011573190 cites W2057522312 @default.
- W2011573190 cites W2057955197 @default.
- W2011573190 cites W2064962253 @default.
- W2011573190 cites W2067011460 @default.
- W2011573190 cites W2072993227 @default.
- W2011573190 cites W2076948526 @default.
- W2011573190 cites W2086156623 @default.
- W2011573190 cites W2100634348 @default.
- W2011573190 cites W2109827369 @default.
- W2011573190 cites W2116179634 @default.
- W2011573190 cites W2119921083 @default.
- W2011573190 cites W2120977260 @default.
- W2011573190 cites W2134607822 @default.
- W2011573190 cites W2151664404 @default.
- W2011573190 cites W2166321298 @default.
- W2011573190 cites W2169789149 @default.
- W2011573190 cites W2171697262 @default.
- W2011573190 cites W2318141305 @default.
- W2011573190 cites W4249623900 @default.
- W2011573190 cites W4300454115 @default.
- W2011573190 doi "https://doi.org/10.1186/1471-2407-11-269" @default.
- W2011573190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3146937" @default.
- W2011573190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21702963" @default.
- W2011573190 hasPublicationYear "2011" @default.
- W2011573190 type Work @default.
- W2011573190 sameAs 2011573190 @default.
- W2011573190 citedByCount "47" @default.
- W2011573190 countsByYear W20115731902012 @default.
- W2011573190 countsByYear W20115731902013 @default.
- W2011573190 countsByYear W20115731902014 @default.
- W2011573190 countsByYear W20115731902015 @default.
- W2011573190 countsByYear W20115731902016 @default.
- W2011573190 countsByYear W20115731902017 @default.
- W2011573190 countsByYear W20115731902018 @default.
- W2011573190 countsByYear W20115731902020 @default.
- W2011573190 countsByYear W20115731902021 @default.
- W2011573190 countsByYear W20115731902022 @default.
- W2011573190 countsByYear W20115731902023 @default.
- W2011573190 crossrefType "journal-article" @default.
- W2011573190 hasAuthorship W2011573190A5008260288 @default.
- W2011573190 hasAuthorship W2011573190A5016873527 @default.
- W2011573190 hasAuthorship W2011573190A5017021744 @default.
- W2011573190 hasAuthorship W2011573190A5026614969 @default.
- W2011573190 hasAuthorship W2011573190A5055734763 @default.
- W2011573190 hasAuthorship W2011573190A5062258585 @default.
- W2011573190 hasAuthorship W2011573190A5065576440 @default.
- W2011573190 hasAuthorship W2011573190A5070392597 @default.
- W2011573190 hasAuthorship W2011573190A5076092861 @default.
- W2011573190 hasAuthorship W2011573190A5080849169 @default.
- W2011573190 hasBestOaLocation W20115731901 @default.
- W2011573190 hasConcept C126322002 @default.
- W2011573190 hasConcept C126894567 @default.
- W2011573190 hasConcept C142724271 @default.
- W2011573190 hasConcept C2776151105 @default.
- W2011573190 hasConcept C2776914184 @default.
- W2011573190 hasConcept C2777714996 @default.
- W2011573190 hasConcept C2777961210 @default.
- W2011573190 hasConcept C2780559512 @default.
- W2011573190 hasConcept C2781244666 @default.
- W2011573190 hasConcept C2989005 @default.
- W2011573190 hasConcept C509974204 @default.
- W2011573190 hasConcept C71924100 @default.
- W2011573190 hasConcept C90924648 @default.
- W2011573190 hasConceptScore W2011573190C126322002 @default.
- W2011573190 hasConceptScore W2011573190C126894567 @default.
- W2011573190 hasConceptScore W2011573190C142724271 @default.