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- W2011576618 abstract "beta-Casomorphin derivatives without the N-terminal amino acid tyrosine possess memory-improving effects after central and peripheral application. We investigated the significance of adrenal glands for the memory improving effect of the systemically applied beta-casomorphin derivative des-Tyr-D-Pro4CM (Pro-Phe-D-Pro-Gly) in a learning experiment. Seven-week-old rats were adrenalectomized or sham operated. One week after surgery the rats were trained in an active avoidance task in a shuttle box. Five avoidance reactions were taken as learning criterion. After training 10 nmol/kg des-Tyr-D-Pro4CM or saline (10 ml/kg) was subcutaneously applied. There were no differences in acquisition between adrenalectomized and sham-operated rats. The memory retention of sham-operated animals was improved by des-Tyr-D-Pro4CM. In adrenalectomized rats this positive effect could not be observed. The involvement of adrenal glands in the peptide effect during learning and retention is discussed." @default.
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- W2011576618 title "Adrenalectomy attenuates the improvement of memory in rats by peripheral application of des-Tyr-d-Pro4-casomorphin" @default.
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- W2011576618 doi "https://doi.org/10.1016/0163-1047(93)91117-6" @default.
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