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- W2011578064 endingPage "2756" @default.
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- W2011578064 abstract "The drug discovery process for drugs that target the central nervous system suffers from a very high rate of failure due to the presence of the blood-brain barrier, which limits the entry of xenobiotics into the brain. To minimise drug failure at different stages of the drug development process, new methodologies have been developed to understand the absorption, distribution, metabolism, excretion and toxicity (ADMET) profile of drug candidates at early stages of drug development. Additionally, understanding the permeation of drug candidates is also important, particularly for drugs that target the central nervous system. During the first stages of the drug discovery process, in vitro methods that allow for the determination of permeability using high-throughput screening methods are advantageous. For example, performing the parallel artificial membrane permeability assay followed by cell-based models with interesting hits is a useful technique for identifying potential drugs. In silico models also provide interesting information but must be confirmed by in vitro models. Finally, in vivo models, such as in situ brain perfusion, should be studied to reduce a large number of drug candidates to a few lead compounds. This article reviews the different methodologies used in the drug discovery and drug development processes to determine the permeation of drug candidates through the blood-brain barrier." @default.
- W2011578064 created "2016-06-24" @default.
- W2011578064 creator A5003426636 @default.
- W2011578064 creator A5014486326 @default.
- W2011578064 creator A5051263081 @default.
- W2011578064 creator A5078273093 @default.
- W2011578064 date "2013-06-26" @default.
- W2011578064 modified "2023-10-18" @default.
- W2011578064 title "Methodologies to Assess Drug Permeation Through the Blood–Brain Barrier for Pharmaceutical Research" @default.
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