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• W2011592968 abstract "During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Leprdb/Leprdb mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10 mg/kg in both 1- and 3-month-old Leprdb/Leprdb mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Leprdb/Leprdb mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B." @default.
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• W2011592968 date "2005-01-01" @default.
• W2011592968 modified "2023-10-16" @default.
• W2011592968 title "Antidiabetic effects of extracts from Psidium guajava" @default.
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• W2011592968 doi "https://doi.org/10.1016/j.jep.2004.09.041" @default.
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