FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011596307> ?p ?o ?g. }

• W2011596307 endingPage "1166" @default.
• W2011596307 startingPage "1155" @default.
• W2011596307 abstract "Abstract Postzygotic isolation between incipient species results from the accumulation of incompatibilities that arise as a consequence of genetic divergence. When phenotypes are determined by regulatory interactions, hybrid incompatibility can evolve even as a consequence of parallel adaptation in parental populations because interacting genes can produce the same phenotype through incompatible allelic combinations. We explore the evolutionary conditions that promote and constrain hybrid incompatibility in regulatory networks using a bioenergetic model (combining thermodynamics and kinetics) of transcriptional regulation, considering the bioenergetic basis of molecular interactions between transcription factors (TFs) and their binding sites. The bioenergetic parameters consider the free energy of formation of the bond between the TF and its binding site and the availability of TFs in the intracellular environment. Together these determine fractional occupancy of the TF on the promoter site, the degree of subsequent gene expression and in diploids, and the degree of dominance among allelic interactions. This results in a sigmoid genotype–phenotype map and fitness landscape, with the details of the shape determining the degree of bioenergetic evolutionary constraint on hybrid incompatibility. Using individual-based simulations, we subjected two allopatric populations to parallel directional or stabilizing selection. Misregulation of hybrid gene expression occurred under either type of selection, although it evolved faster under directional selection. Under directional selection, the extent of hybrid incompatibility increased with the slope of the genotype–phenotype map near the derived parental expression level. Under stabilizing selection, hybrid incompatibility arose from compensatory mutations and was greater when the bioenergetic properties of the interaction caused the space of nearly neutral genotypes around the stable expression level to be wide. F2’s showed higher hybrid incompatibility than F1’s to the extent that the bioenergetic properties favored dominant regulatory interactions. The present model is a mechanistically explicit case of the Bateson–Dobzhansky–Muller model, connecting environmental selective pressure to hybrid incompatibility through the molecular mechanism of regulatory divergence. The bioenergetic parameters that determine expression represent measurable properties of transcriptional regulation, providing a predictive framework for empirical studies of how phenotypic evolution results in epistatic incompatibility at the molecular level in hybrids." @default.
• W2011596307 created "2016-06-24" @default.
• W2011596307 creator A5006875214 @default.
• W2011596307 creator A5020693225 @default.
• W2011596307 creator A5051168598 @default.
• W2011596307 creator A5051901205 @default.
• W2011596307 date "2014-08-29" @default.
• W2011596307 modified "2023-09-26" @default.
• W2011596307 title "Hybrid Incompatibility Arises in a Sequence-Based Bioenergetic Model of Transcription Factor Binding" @default.
• W2011596307 cites W1963761245 @default.
• W2011596307 cites W1967749294 @default.
• W2011596307 cites W1968647692 @default.
• W2011596307 cites W1980253661 @default.
• W2011596307 cites W1981336731 @default.
• W2011596307 cites W1981779495 @default.
• W2011596307 cites W1995649500 @default.
• W2011596307 cites W1996264210 @default.
• W2011596307 cites W2011145067 @default.
• W2011596307 cites W2012354488 @default.
• W2011596307 cites W2020766456 @default.
• W2011596307 cites W2025991849 @default.
• W2011596307 cites W2033282516 @default.
• W2011596307 cites W2035300844 @default.
• W2011596307 cites W2051645586 @default.
• W2011596307 cites W2052469882 @default.
• W2011596307 cites W2067284308 @default.
• W2011596307 cites W2068415520 @default.
• W2011596307 cites W2069319713 @default.
• W2011596307 cites W2081002636 @default.
• W2011596307 cites W2082682118 @default.
• W2011596307 cites W2084125253 @default.
• W2011596307 cites W2085454778 @default.
• W2011596307 cites W2086567311 @default.
• W2011596307 cites W2089806726 @default.
• W2011596307 cites W2092809119 @default.
• W2011596307 cites W2093403092 @default.
• W2011596307 cites W2100305057 @default.
• W2011596307 cites W2100618392 @default.
• W2011596307 cites W2102176540 @default.
• W2011596307 cites W2111408573 @default.
• W2011596307 cites W2111774474 @default.
• W2011596307 cites W2112823093 @default.
• W2011596307 cites W2121763778 @default.
• W2011596307 cites W2122452605 @default.
• W2011596307 cites W2133147430 @default.
• W2011596307 cites W2134437816 @default.
• W2011596307 cites W2139137018 @default.
• W2011596307 cites W2140542639 @default.
• W2011596307 cites W2143855992 @default.
• W2011596307 cites W2150368341 @default.
• W2011596307 cites W2152095546 @default.
• W2011596307 cites W2153124993 @default.
• W2011596307 cites W2157424463 @default.
• W2011596307 cites W2161376294 @default.
• W2011596307 cites W2166472624 @default.
• W2011596307 cites W2168004137 @default.
• W2011596307 cites W2171463101 @default.
• W2011596307 cites W3105662792 @default.
• W2011596307 cites W4251042002 @default.
• W2011596307 cites W4317527510 @default.
• W2011596307 doi "https://doi.org/10.1534/genetics.114.168112" @default.
• W2011596307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224158" @default.
• W2011596307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25173845" @default.
• W2011596307 hasPublicationYear "2014" @default.
• W2011596307 type Work @default.
• W2011596307 sameAs 2011596307 @default.
• W2011596307 citedByCount "43" @default.
• W2011596307 countsByYear W20115963072015 @default.
• W2011596307 countsByYear W20115963072016 @default.
• W2011596307 countsByYear W20115963072017 @default.
• W2011596307 countsByYear W20115963072018 @default.
• W2011596307 countsByYear W20115963072019 @default.
• W2011596307 countsByYear W20115963072020 @default.
• W2011596307 countsByYear W20115963072021 @default.
• W2011596307 countsByYear W20115963072022 @default.
• W2011596307 countsByYear W20115963072023 @default.
• W2011596307 crossrefType "journal-article" @default.
• W2011596307 hasAuthorship W2011596307A5006875214 @default.
• W2011596307 hasAuthorship W2011596307A5020693225 @default.
• W2011596307 hasAuthorship W2011596307A5051168598 @default.
• W2011596307 hasAuthorship W2011596307A5051901205 @default.
• W2011596307 hasBestOaLocation W20115963071 @default.
• W2011596307 hasConcept C104317684 @default.
• W2011596307 hasConcept C127716648 @default.
• W2011596307 hasConcept C54355233 @default.
• W2011596307 hasConcept C68873052 @default.
• W2011596307 hasConcept C78458016 @default.
• W2011596307 hasConcept C86339819 @default.
• W2011596307 hasConcept C86803240 @default.
• W2011596307 hasConcept C90032942 @default.
• W2011596307 hasConceptScore W2011596307C104317684 @default.
• W2011596307 hasConceptScore W2011596307C127716648 @default.
• W2011596307 hasConceptScore W2011596307C54355233 @default.
• W2011596307 hasConceptScore W2011596307C68873052 @default.
• W2011596307 hasConceptScore W2011596307C78458016 @default.
• W2011596307 hasConceptScore W2011596307C86339819 @default.
• W2011596307 hasConceptScore W2011596307C86803240 @default.
• W2011596307 hasConceptScore W2011596307C90032942 @default.

• next