FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011607383> ?p ?o ?g. }

• W2011607383 endingPage "139" @default.
• W2011607383 startingPage "129" @default.
• W2011607383 abstract "An attenuated equine infectious anemia virus (EIAV), V26, was previously prepared by 50 passages of the Japanese virulent strain V70 in primary horse macrophage culture. The horses inoculated with this V26 virus were shown to raise neutralizing antibodies against V70 without any viremia. Here, we investigated the in vitro and in vivo replication ability of V26. Comparison of the long-terminal repeat (LTR) sequences between V26 and V70 revealed a large insertion within the LTR U3 hypervariable region of V26. V26 with the mutation in the LTR showed much higher promoter activity in vitro than V70. This is consistent with the much higher replication rate of V26 in horse primary macrophage cultures compared with V70. In sharp contrast, we failed to identify the V26-specific LTR sequence by PCR, at least in sequential samples of plasma or peripheral blood mononuclear cells derived from three horses until day 62 after V26 inoculation. In contrast, antibody responses to EIAV were observed in all horses. The results suggest that the replication ability of V26 in vivo is extremely low. When one of the horses was subsequently challenged with cell-associated V70, it was found that the horse became PCR positive for EIAV. There was no LTR mutation in EIAV genome in samples periodically prepared from the V70-challenged horse. Thus it was suggested that the LTR mutation in EIAV, which occurs during serial passage in vitro, affects EIAV replication in vitro and in vivo." @default.
• W2011607383 created "2016-06-24" @default.
• W2011607383 creator A5001759370 @default.
• W2011607383 creator A5004375935 @default.
• W2011607383 creator A5016195460 @default.
• W2011607383 creator A5019599463 @default.
• W2011607383 creator A5022951509 @default.
• W2011607383 creator A5023255479 @default.
• W2011607383 creator A5025567169 @default.
• W2011607383 creator A5034474882 @default.
• W2011607383 creator A5045175134 @default.
• W2011607383 creator A5074002817 @default.
• W2011607383 creator A5077891676 @default.
• W2011607383 date "2000-01-01" @default.
• W2011607383 modified "2023-09-30" @default.
• W2011607383 title "Replication Ability in Vitro and in Vivo of Equine Infectious Anemia Virus Avirulent Japanese Strain" @default.
• W2011607383 cites W1535348334 @default.
• W2011607383 cites W1555598192 @default.
• W2011607383 cites W1559656254 @default.
• W2011607383 cites W1563465785 @default.
• W2011607383 cites W1582963807 @default.
• W2011607383 cites W1588896166 @default.
• W2011607383 cites W1742019737 @default.
• W2011607383 cites W1809295614 @default.
• W2011607383 cites W1852584301 @default.
• W2011607383 cites W1876563867 @default.
• W2011607383 cites W1878135792 @default.
• W2011607383 cites W1896737842 @default.
• W2011607383 cites W1923224286 @default.
• W2011607383 cites W1928121315 @default.
• W2011607383 cites W1978854279 @default.
• W2011607383 cites W2015979176 @default.
• W2011607383 cites W2016780880 @default.
• W2011607383 cites W2017562082 @default.
• W2011607383 cites W2020423904 @default.
• W2011607383 cites W2065139987 @default.
• W2011607383 cites W2079198806 @default.
• W2011607383 cites W2096607681 @default.
• W2011607383 cites W2122678447 @default.
• W2011607383 cites W2126891112 @default.
• W2011607383 cites W2128629527 @default.
• W2011607383 cites W2144784540 @default.
• W2011607383 cites W2169925896 @default.
• W2011607383 cites W2338825587 @default.
• W2011607383 doi "https://doi.org/10.1006/viro.1999.0076" @default.
• W2011607383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10612667" @default.
• W2011607383 hasPublicationYear "2000" @default.
• W2011607383 type Work @default.
• W2011607383 sameAs 2011607383 @default.
• W2011607383 citedByCount "11" @default.
• W2011607383 countsByYear W20116073832014 @default.
• W2011607383 countsByYear W20116073832018 @default.
• W2011607383 crossrefType "journal-article" @default.
• W2011607383 hasAuthorship W2011607383A5001759370 @default.
• W2011607383 hasAuthorship W2011607383A5004375935 @default.
• W2011607383 hasAuthorship W2011607383A5016195460 @default.
• W2011607383 hasAuthorship W2011607383A5019599463 @default.
• W2011607383 hasAuthorship W2011607383A5022951509 @default.
• W2011607383 hasAuthorship W2011607383A5023255479 @default.
• W2011607383 hasAuthorship W2011607383A5025567169 @default.
• W2011607383 hasAuthorship W2011607383A5034474882 @default.
• W2011607383 hasAuthorship W2011607383A5045175134 @default.
• W2011607383 hasAuthorship W2011607383A5074002817 @default.
• W2011607383 hasAuthorship W2011607383A5077891676 @default.
• W2011607383 hasBestOaLocation W20116073831 @default.
• W2011607383 hasConcept C140704245 @default.
• W2011607383 hasConcept C159047783 @default.
• W2011607383 hasConcept C202751555 @default.
• W2011607383 hasConcept C207001950 @default.
• W2011607383 hasConcept C2522874641 @default.
• W2011607383 hasConcept C2781053568 @default.
• W2011607383 hasConcept C54355233 @default.
• W2011607383 hasConcept C86803240 @default.
• W2011607383 hasConceptScore W2011607383C140704245 @default.
• W2011607383 hasConceptScore W2011607383C159047783 @default.
• W2011607383 hasConceptScore W2011607383C202751555 @default.
• W2011607383 hasConceptScore W2011607383C207001950 @default.
• W2011607383 hasConceptScore W2011607383C2522874641 @default.
• W2011607383 hasConceptScore W2011607383C2781053568 @default.
• W2011607383 hasConceptScore W2011607383C54355233 @default.
• W2011607383 hasConceptScore W2011607383C86803240 @default.
• W2011607383 hasIssue "1" @default.
• W2011607383 hasLocation W20116073831 @default.
• W2011607383 hasLocation W20116073832 @default.
• W2011607383 hasOpenAccess W2011607383 @default.
• W2011607383 hasPrimaryLocation W20116073831 @default.
• W2011607383 hasRelatedWork W1487857142 @default.
• W2011607383 hasRelatedWork W1923224286 @default.
• W2011607383 hasRelatedWork W1979807665 @default.
• W2011607383 hasRelatedWork W2028912289 @default.
• W2011607383 hasRelatedWork W2032810199 @default.
• W2011607383 hasRelatedWork W2148610111 @default.
• W2011607383 hasRelatedWork W2152779030 @default.
• W2011607383 hasRelatedWork W2351571969 @default.
• W2011607383 hasRelatedWork W2355191493 @default.
• W2011607383 hasRelatedWork W2481551380 @default.
• W2011607383 hasVolume "266" @default.
• W2011607383 isParatext "false" @default.

• next