FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011615847> ?p ?o ?g. }

• W2011615847 endingPage "276" @default.
• W2011615847 startingPage "265" @default.
• W2011615847 abstract "Several lines of evidence suggest that the piriform cortex functions as a generator in the development and propagation of forebrain (limbic type) seizures, particularly in the kindling model of epilepsy. It is, however, not clear where, within the rather large piriform cortex region, the generator resides, and how much tissue is involved. Highly sensitive loci to chemical or electrical stimulation have been described both in the deep anterior and posterior parts of the piriform cortex. Furthermore, data from piriform cortex slice preparations indicated that epileptiform potentials originate in deep structures, particularly the endopiriform nucleus that underlies the piriform cortex. In the present study, in rats, we implanted stimulation and recording electrodes in various rostrocaudal locations of the piriform cortex and endopiriform nucleus, including the “area tempestas” i.e., a structure in the anterior part of the piriform cortex previously proposed to be critically involved in the generation of convulsive seizures of limbic origin. Within the piriform cortex, electrodes were aimed at different cellular layers of this structure. For comparison, additional animals received electrodes in different parts of the basolateral amygdala. A total of 19 different locations was obtained in this way. The susceptibility of these locations to electrical stimulation was characterized by determining the threshold for induction of afterdischarges. The afterdischarge threshold was lowest in layer III of the posterior piriform cortex and some locations in the endopiriform nucleus, whereas amygdala and “area tempestas” displayed higher values. In several animals, particularly those with electrodes in layer III of the posterior piriform cortex, spontaneous spiking was seen in prestimulation recordings, whereas this was never observed in recordings from the amygdala. Subsequent kindling by repeated stimulation of the various locations demonstrated marked differences in afterdischarge threshold reduction and kindling rate. The most marked decreases in afterdischarge threshold were seen in locations within layer III of the piriform cortex, whereas several other locations, including the “area tempestas”, exhibited only moderate decreases or no decrease at all. In contrast to previous observations with only few locations in the piriform cortex region, the posterior piriform cortex was not in general slower to kindle than the anterior piriform cortex, although some locations in the posterior piriform cortex exhibited significantly lower kindling rates than the amygdala. The highest kindling rate was seen in the dorsal endopiriform nucleus. When the stepwise progression of kindling was studied, several locations in the piriform cortex stayed for long periods in the early and middle, i.e. focal stages of the kindling process, thus refuting previous suggestions that the piriform cortex generally proceeds rapidly through these stages. Behavioral characteristics of seizures kindled from the diverse sites did not differ. In conclusion, within the amygdala-piriform cortex region, the most sensitive cells to electrical induction of afterdischarge and reduction of afterdischarge threshold by repeated electrical stimulation reside in layer III of the posterior piriform cortex, while the anterior part of the piriform cortex, including the locus previously termed “area tempestas”, is less susceptible in this regard. In contrast to the marked decrease in afterdischarge threshold, several locations in the posterior piriform cortex kindle only slowly, thus demonstrating a separation between decrease in seizure threshold and increase in seizure severity in response to repeated electrical stimulation." @default.
• W2011615847 created "2016-06-24" @default.
• W2011615847 creator A5007732554 @default.
• W2011615847 creator A5010235451 @default.
• W2011615847 creator A5025713631 @default.
• W2011615847 creator A5078172111 @default.
• W2011615847 date "1995-05-01" @default.
• W2011615847 modified "2023-09-25" @default.
• W2011615847 title "Susceptibility of different cell layers of the anterior and posterior part of the piriform cortex to electrical stimulation and kindling: comparison with the basolateral amygdala and “area tempestas”" @default.
• W2011615847 cites W1500243402 @default.
• W2011615847 cites W1609394567 @default.
• W2011615847 cites W1963498769 @default.
• W2011615847 cites W1966416366 @default.
• W2011615847 cites W1981948963 @default.
• W2011615847 cites W1989400013 @default.
• W2011615847 cites W1994130857 @default.
• W2011615847 cites W1994312297 @default.
• W2011615847 cites W2002608596 @default.
• W2011615847 cites W2003926011 @default.
• W2011615847 cites W2011176838 @default.
• W2011615847 cites W2013568401 @default.
• W2011615847 cites W2014367829 @default.
• W2011615847 cites W2032661877 @default.
• W2011615847 cites W2036278822 @default.
• W2011615847 cites W2037605538 @default.
• W2011615847 cites W2039105482 @default.
• W2011615847 cites W2039236424 @default.
• W2011615847 cites W2045855320 @default.
• W2011615847 cites W2046014420 @default.
• W2011615847 cites W2049381848 @default.
• W2011615847 cites W2052012507 @default.
• W2011615847 cites W2057879030 @default.
• W2011615847 cites W2063413260 @default.
• W2011615847 cites W2068010983 @default.
• W2011615847 cites W2079730655 @default.
• W2011615847 cites W2081817613 @default.
• W2011615847 cites W2082488891 @default.
• W2011615847 cites W2084303371 @default.
• W2011615847 cites W2085251042 @default.
• W2011615847 cites W2103946141 @default.
• W2011615847 cites W2121333375 @default.
• W2011615847 cites W2337860672 @default.
• W2011615847 cites W2409130643 @default.
• W2011615847 doi "https://doi.org/10.1016/0306-4522(94)00614-b" @default.
• W2011615847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7477871" @default.
• W2011615847 hasPublicationYear "1995" @default.
• W2011615847 type Work @default.
• W2011615847 sameAs 2011615847 @default.
• W2011615847 citedByCount "74" @default.
• W2011615847 countsByYear W20116158472012 @default.
• W2011615847 countsByYear W20116158472013 @default.
• W2011615847 countsByYear W20116158472014 @default.
• W2011615847 countsByYear W20116158472015 @default.
• W2011615847 countsByYear W20116158472017 @default.
• W2011615847 countsByYear W20116158472019 @default.
• W2011615847 countsByYear W20116158472020 @default.
• W2011615847 countsByYear W20116158472022 @default.
• W2011615847 crossrefType "journal-article" @default.
• W2011615847 hasAuthorship W2011615847A5007732554 @default.
• W2011615847 hasAuthorship W2011615847A5010235451 @default.
• W2011615847 hasAuthorship W2011615847A5025713631 @default.
• W2011615847 hasAuthorship W2011615847A5078172111 @default.
• W2011615847 hasConcept C100691959 @default.
• W2011615847 hasConcept C105702510 @default.
• W2011615847 hasConcept C110726550 @default.
• W2011615847 hasConcept C169760540 @default.
• W2011615847 hasConcept C185592680 @default.
• W2011615847 hasConcept C201792869 @default.
• W2011615847 hasConcept C24998067 @default.
• W2011615847 hasConcept C2777348757 @default.
• W2011615847 hasConcept C2778340768 @default.
• W2011615847 hasConcept C2779144063 @default.
• W2011615847 hasConcept C2780382662 @default.
• W2011615847 hasConcept C2780496858 @default.
• W2011615847 hasConcept C2780723820 @default.
• W2011615847 hasConcept C529278444 @default.
• W2011615847 hasConcept C541082541 @default.
• W2011615847 hasConcept C86803240 @default.
• W2011615847 hasConceptScore W2011615847C100691959 @default.
• W2011615847 hasConceptScore W2011615847C105702510 @default.
• W2011615847 hasConceptScore W2011615847C110726550 @default.
• W2011615847 hasConceptScore W2011615847C169760540 @default.
• W2011615847 hasConceptScore W2011615847C185592680 @default.
• W2011615847 hasConceptScore W2011615847C201792869 @default.
• W2011615847 hasConceptScore W2011615847C24998067 @default.
• W2011615847 hasConceptScore W2011615847C2777348757 @default.
• W2011615847 hasConceptScore W2011615847C2778340768 @default.
• W2011615847 hasConceptScore W2011615847C2779144063 @default.
• W2011615847 hasConceptScore W2011615847C2780382662 @default.
• W2011615847 hasConceptScore W2011615847C2780496858 @default.
• W2011615847 hasConceptScore W2011615847C2780723820 @default.
• W2011615847 hasConceptScore W2011615847C529278444 @default.
• W2011615847 hasConceptScore W2011615847C541082541 @default.
• W2011615847 hasConceptScore W2011615847C86803240 @default.
• W2011615847 hasIssue "2" @default.
• W2011615847 hasLocation W20116158471 @default.
• W2011615847 hasLocation W20116158472 @default.
• W2011615847 hasOpenAccess W2011615847 @default.

• next