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- W2011616478 abstract "Protein kinase C (PKC) is a family of phospholipid-dependent kinases that is involved, along with calcium mobilization, in the activation of human platelets. Since interleukin-3 (IL-3) has been shown to act, in part, by activating PKC, we investigated the effect of IL-3 on PKC activity and content in human platelets. Exposure of platelets to 10 ng/ml of IL-3 was associated with a rapid (i.e., within 3 minutes) translocation of PKC activity and content from the cytosol to the membrane fraction. In addition, treatment with IL-3 effected a time-dependent down-regulation of PKC activity and content. We speculate that IL-3 may act as a modulator of PKC-dependent pathways in the human platelet." @default.
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- W2011616478 date "1992-06-01" @default.
- W2011616478 modified "2023-10-16" @default.
- W2011616478 title "Interleukin-3 induces translocation and down-regulation of protein kinase C in human platelets" @default.
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- W2011616478 doi "https://doi.org/10.1016/0006-291x(92)91677-i" @default.
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