FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011617296> ?p ?o ?g. }

• W2011617296 endingPage "7289" @default.
• W2011617296 startingPage "7284" @default.
• W2011617296 abstract "During animal development, regions of the embryo become committed to position-specific identities, which are determined by spatially restricted expression of Hox/homeotic genes. This expression pattern is initially established by the activity of the segmentation genes and is subsequently maintained during the proliferative stage through the action of transcription factors encoded by the trithorax (trx) and Polycomb ( Pc ) groups of genes . trithorax (trx) and ash1 (absent, small, or homeotic 1) are members of the Drosophila trx group. Their products are associated with chromosomes and are believed to activate transcription of target genes through chromatin remodeling. Recently, we reported molecular studies indicating that TRX and ASH1 proteins act in concert to bind simultaneously to response elements located at close proximity within the same set of target genes. Extension of these and other studies to mammalian systems required identification and cloning of the mammalian homologue of ash1 (the mammalian homologue of trx , ALL-1, was previously cloned). We have identified a human expressed sequence tag (EST) clone with similarity to the SET domain of Drosophila ASH1, and used it to clone the human gene. huASH1 resides at chromosomal band 1q21. The gene is expressed in multiple tissues as an ≈10.5-kb transcript and encodes a protein of 2962 residues. The protein contains a SET domain, a PHD finger, four AT hooks, and a region with homology to the bromodomain. The last region is not present in Drosophila ASH1, and as such might confer to the human protein a unique additional function. Using several anti-huASH1 Ab for immunostaining of cultured cells, we found that the protein is distributed in intranuclear speckles, and unexpectedly also in intercellular junctions. Double-immunofluorescence labeling of huASH1 and several junctional proteins localized the huASH1 protein into tight junctions. The significance of huASH1 dual location is discussed. In particular, we consider the possibility that translocation of the protein between the junctional membrane and the nucleus may be involved in adhesion-mediated signaling." @default.
• W2011617296 created "2016-06-24" @default.
• W2011617296 creator A5000768230 @default.
• W2011617296 creator A5016331106 @default.
• W2011617296 creator A5019706232 @default.
• W2011617296 creator A5028652571 @default.
• W2011617296 creator A5038925921 @default.
• W2011617296 creator A5043281173 @default.
• W2011617296 creator A5046264807 @default.
• W2011617296 creator A5060073633 @default.
• W2011617296 creator A5079700663 @default.
• W2011617296 creator A5085063614 @default.
• W2011617296 date "2000-06-20" @default.
• W2011617296 modified "2023-10-02" @default.
• W2011617296 title "huASH1 protein, a putative transcription factor encoded by a human homologue of the <i>Drosophila ash1</i> gene, localizes to both nuclei and cell–cell tight junctions" @default.
• W2011617296 cites W129013773 @default.
• W2011617296 cites W1481473039 @default.
• W2011617296 cites W1533604650 @default.
• W2011617296 cites W1533942477 @default.
• W2011617296 cites W1625510017 @default.
• W2011617296 cites W1660631781 @default.
• W2011617296 cites W1900883967 @default.
• W2011617296 cites W1976577927 @default.
• W2011617296 cites W1976736755 @default.
• W2011617296 cites W1982640053 @default.
• W2011617296 cites W1989145865 @default.
• W2011617296 cites W1992916802 @default.
• W2011617296 cites W1998475589 @default.
• W2011617296 cites W1999752453 @default.
• W2011617296 cites W2006718453 @default.
• W2011617296 cites W2024615596 @default.
• W2011617296 cites W2028224423 @default.
• W2011617296 cites W2037481900 @default.
• W2011617296 cites W2039597909 @default.
• W2011617296 cites W2043888207 @default.
• W2011617296 cites W2063904948 @default.
• W2011617296 cites W2065422635 @default.
• W2011617296 cites W2065813594 @default.
• W2011617296 cites W2084555620 @default.
• W2011617296 cites W2087172939 @default.
• W2011617296 cites W2088516964 @default.
• W2011617296 cites W2090904095 @default.
• W2011617296 cites W2091677482 @default.
• W2011617296 cites W2092411127 @default.
• W2011617296 cites W2093690932 @default.
• W2011617296 cites W2095184701 @default.
• W2011617296 cites W2097808068 @default.
• W2011617296 cites W2107601924 @default.
• W2011617296 cites W2108709755 @default.
• W2011617296 cites W2117344426 @default.
• W2011617296 cites W2118281253 @default.
• W2011617296 cites W2124220437 @default.
• W2011617296 cites W2132212013 @default.
• W2011617296 cites W2142111204 @default.
• W2011617296 cites W2143776806 @default.
• W2011617296 cites W2154171643 @default.
• W2011617296 cites W2169333252 @default.
• W2011617296 cites W2174739588 @default.
• W2011617296 cites W277446671 @default.
• W2011617296 cites W4300141132 @default.
• W2011617296 doi "https://doi.org/10.1073/pnas.97.13.7284" @default.
• W2011617296 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/16537" @default.
• W2011617296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10860993" @default.
• W2011617296 hasPublicationYear "2000" @default.
• W2011617296 type Work @default.
• W2011617296 sameAs 2011617296 @default.
• W2011617296 citedByCount "110" @default.
• W2011617296 countsByYear W20116172962012 @default.
• W2011617296 countsByYear W20116172962013 @default.
• W2011617296 countsByYear W20116172962014 @default.
• W2011617296 countsByYear W20116172962015 @default.
• W2011617296 countsByYear W20116172962016 @default.
• W2011617296 countsByYear W20116172962017 @default.
• W2011617296 countsByYear W20116172962018 @default.
• W2011617296 countsByYear W20116172962020 @default.
• W2011617296 countsByYear W20116172962021 @default.
• W2011617296 countsByYear W20116172962022 @default.
• W2011617296 crossrefType "journal-article" @default.
• W2011617296 hasAuthorship W2011617296A5000768230 @default.
• W2011617296 hasAuthorship W2011617296A5016331106 @default.
• W2011617296 hasAuthorship W2011617296A5019706232 @default.
• W2011617296 hasAuthorship W2011617296A5028652571 @default.
• W2011617296 hasAuthorship W2011617296A5038925921 @default.
• W2011617296 hasAuthorship W2011617296A5043281173 @default.
• W2011617296 hasAuthorship W2011617296A5046264807 @default.
• W2011617296 hasAuthorship W2011617296A5060073633 @default.
• W2011617296 hasAuthorship W2011617296A5079700663 @default.
• W2011617296 hasAuthorship W2011617296A5085063614 @default.
• W2011617296 hasBestOaLocation W20116172962 @default.
• W2011617296 hasConcept C104317684 @default.
• W2011617296 hasConcept C111039654 @default.
• W2011617296 hasConcept C138885662 @default.
• W2011617296 hasConcept C179926584 @default.
• W2011617296 hasConcept C2780104201 @default.
• W2011617296 hasConcept C41895202 @default.
• W2011617296 hasConcept C46751350 @default.
• W2011617296 hasConcept C54355233 @default.
• W2011617296 hasConcept C64927066 @default.

• next