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- W2011617521 abstract "As part of our program to develop PET tracers for the 5-HT reuptake site, venlafaxine, a non-classical, fast-acting antidepressant, was selected as a candidate for labelling with 11C for in vivo evaluation. [O-methyl-11C]venlafaxine was produced by the alkylation of O-desmethyl venlafaxine with [11C]methyl iodide followed by HPLC purification and formulation. Radiochemically pure [O-methyl-11C]venlafaxine was obtained in a 30 ± 5 % decay corrected radiochemical yield and a specific activity > 50 GBq / μmol (1.4 Ci / μmol) at the end of synthesis. For a typical production starting with 46 GBq (1.3 Ci) [11C]CO2, 5.2 GBq (140 mCi) [O-methyl-11C]venlafaxine was obtained as a sterile, formulated solution in a synthesis time of 30 min (counted from EOB). © 1997 John Wiley & Sons, Ltd." @default.
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- W2011617521 date "1997-01-01" @default.
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- W2011617521 title "The synthesis of [o-methyl-11C]venlafaxine: A non-classical, fast-acting antidepressant" @default.
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- W2011617521 doi "https://doi.org/10.1002/(sici)1099-1344(199701)39:1<89::aid-jlcr944>3.0.co;2-l" @default.
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