Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011640110> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2011640110 endingPage "177" @default.
- W2011640110 startingPage "171" @default.
- W2011640110 abstract "To explore the rules for mammalian splice-site selection using a statistical approach, we constructed an aberrant splicing database containing an extensive collection of mammalian genetic disease mutations (90 genes, 209 mutations). From this database, we confirmed that: (1) more than 90% of mutations either destroy or create the splice-site consensus sequences; (2) the number of mutations mapped at individual residues in the splice-site regions roughly correlates to their conservation degrees in the consensus sequences; (3) about half of the observed aberrant splicing is exon skipping, while intron retention is rarely observed; (4) almost all of the major cryptic sites, activated by mutations, are mapped within an about 100-nt region from the authentic splice sites. Furthermore, we found that: (5) mutations are observed more frequently in the 5' splice-site region than in the 3' splice site region; (6) splice sites that are newly created by mutations are located upstream from the authentic splice sites. Hopefully, these observations will be used as rules for constructing a more effective prediction system of exon sequences." @default.
- W2011640110 created "2016-06-24" @default.
- W2011640110 creator A5054681585 @default.
- W2011640110 creator A5083782157 @default.
- W2011640110 date "1994-04-01" @default.
- W2011640110 modified "2023-10-16" @default.
- W2011640110 title "Construction of a novel database containing aberrant splicing mutations of mammalian genes" @default.
- W2011640110 cites W1545260380 @default.
- W2011640110 cites W1771001171 @default.
- W2011640110 cites W1931301781 @default.
- W2011640110 cites W1974440868 @default.
- W2011640110 cites W1988271866 @default.
- W2011640110 cites W1994704939 @default.
- W2011640110 cites W2003574926 @default.
- W2011640110 cites W2014181394 @default.
- W2011640110 cites W2015252183 @default.
- W2011640110 cites W2023218737 @default.
- W2011640110 cites W2036056816 @default.
- W2011640110 cites W2040578580 @default.
- W2011640110 cites W2102519771 @default.
- W2011640110 cites W2115149771 @default.
- W2011640110 cites W2124306486 @default.
- W2011640110 cites W2129552484 @default.
- W2011640110 cites W2132978049 @default.
- W2011640110 cites W2083579892 @default.
- W2011640110 doi "https://doi.org/10.1016/0378-1119(94)90567-3" @default.
- W2011640110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8163185" @default.
- W2011640110 hasPublicationYear "1994" @default.
- W2011640110 type Work @default.
- W2011640110 sameAs 2011640110 @default.
- W2011640110 citedByCount "276" @default.
- W2011640110 countsByYear W20116401102012 @default.
- W2011640110 countsByYear W20116401102013 @default.
- W2011640110 countsByYear W20116401102014 @default.
- W2011640110 countsByYear W20116401102015 @default.
- W2011640110 countsByYear W20116401102016 @default.
- W2011640110 countsByYear W20116401102017 @default.
- W2011640110 countsByYear W20116401102018 @default.
- W2011640110 countsByYear W20116401102019 @default.
- W2011640110 countsByYear W20116401102020 @default.
- W2011640110 countsByYear W20116401102021 @default.
- W2011640110 countsByYear W20116401102022 @default.
- W2011640110 countsByYear W20116401102023 @default.
- W2011640110 crossrefType "journal-article" @default.
- W2011640110 hasAuthorship W2011640110A5054681585 @default.
- W2011640110 hasAuthorship W2011640110A5083782157 @default.
- W2011640110 hasConcept C104317684 @default.
- W2011640110 hasConcept C167625842 @default.
- W2011640110 hasConcept C194583182 @default.
- W2011640110 hasConcept C2778776201 @default.
- W2011640110 hasConcept C2780989783 @default.
- W2011640110 hasConcept C36823959 @default.
- W2011640110 hasConcept C501734568 @default.
- W2011640110 hasConcept C54355233 @default.
- W2011640110 hasConcept C54458228 @default.
- W2011640110 hasConcept C54985914 @default.
- W2011640110 hasConcept C62257209 @default.
- W2011640110 hasConcept C67705224 @default.
- W2011640110 hasConcept C70721500 @default.
- W2011640110 hasConcept C86803240 @default.
- W2011640110 hasConcept C94671646 @default.
- W2011640110 hasConceptScore W2011640110C104317684 @default.
- W2011640110 hasConceptScore W2011640110C167625842 @default.
- W2011640110 hasConceptScore W2011640110C194583182 @default.
- W2011640110 hasConceptScore W2011640110C2778776201 @default.
- W2011640110 hasConceptScore W2011640110C2780989783 @default.
- W2011640110 hasConceptScore W2011640110C36823959 @default.
- W2011640110 hasConceptScore W2011640110C501734568 @default.
- W2011640110 hasConceptScore W2011640110C54355233 @default.
- W2011640110 hasConceptScore W2011640110C54458228 @default.
- W2011640110 hasConceptScore W2011640110C54985914 @default.
- W2011640110 hasConceptScore W2011640110C62257209 @default.
- W2011640110 hasConceptScore W2011640110C67705224 @default.
- W2011640110 hasConceptScore W2011640110C70721500 @default.
- W2011640110 hasConceptScore W2011640110C86803240 @default.
- W2011640110 hasConceptScore W2011640110C94671646 @default.
- W2011640110 hasIssue "2" @default.
- W2011640110 hasLocation W20116401101 @default.
- W2011640110 hasLocation W20116401102 @default.
- W2011640110 hasOpenAccess W2011640110 @default.
- W2011640110 hasPrimaryLocation W20116401101 @default.
- W2011640110 hasRelatedWork W1767488132 @default.
- W2011640110 hasRelatedWork W1979564952 @default.
- W2011640110 hasRelatedWork W1998434274 @default.
- W2011640110 hasRelatedWork W2013123757 @default.
- W2011640110 hasRelatedWork W2073387857 @default.
- W2011640110 hasRelatedWork W2126974438 @default.
- W2011640110 hasRelatedWork W2157125050 @default.
- W2011640110 hasRelatedWork W2167914935 @default.
- W2011640110 hasRelatedWork W4213165146 @default.
- W2011640110 hasRelatedWork W4249674248 @default.
- W2011640110 hasVolume "141" @default.
- W2011640110 isParatext "false" @default.
- W2011640110 isRetracted "false" @default.
- W2011640110 magId "2011640110" @default.
- W2011640110 workType "article" @default.