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- W2011644642 abstract "Current approaches aiming to cure type 1 diabetes (T1D) have made a negligible number of patients insulin-independent. In this review, we revisit the role of stem cell (SC)-based applications in curing T1D. The optimal therapeutic approach for T1D should ideally preserve the remaining β-cells, restore β-cell function, and protect the replaced insulin-producing cells from autoimmunity. SCs possess immunological and regenerative properties that could be harnessed to improve the treatment of T1D; indeed, SCs may reestablish peripheral tolerance toward β-cells through reshaping of the immune response and inhibition of autoreactive T-cell function. Furthermore, SC-derived insulin-producing cells are capable of engrafting and reversing hyperglycemia in mice. Bone marrow mesenchymal SCs display a hypoimmunogenic phenotype as well as a broad range of immunomodulatory capabilities, they have been shown to cure newly diabetic nonobese diabetic (NOD) mice, and they are currently undergoing evaluation in two clinical trials. Cord blood SCs have been shown to facilitate the generation of regulatory T cells, thereby reverting hyperglycemia in NOD mice. T1D patients treated with cord blood SCs also did not show any adverse reaction in the absence of major effects on glycometabolic control. Although hematopoietic SCs rarely revert hyperglycemia in NOD mice, they exhibit profound immunomodulatory properties in humans; newly hyperglycemic T1D patients have been successfully reverted to normoglycemia with autologous nonmyeloablative hematopoietic SC transplantation. Finally, embryonic SCs also offer exciting prospects because they are able to generate glucose-responsive insulin-producing cells. Easy enthusiasm should be mitigated mainly because of the potential oncogenicity of SCs." @default.
- W2011644642 created "2016-06-24" @default.
- W2011644642 creator A5028314110 @default.
- W2011644642 creator A5046994122 @default.
- W2011644642 creator A5051210233 @default.
- W2011644642 date "2011-08-23" @default.
- W2011644642 modified "2023-10-16" @default.
- W2011644642 title "Immunological Applications of Stem Cells in Type 1 Diabetes" @default.
- W2011644642 cites W122755776 @default.
- W2011644642 cites W125090202 @default.
- W2011644642 cites W1503074982 @default.
- W2011644642 cites W1507258865 @default.
- W2011644642 cites W1510928501 @default.
- W2011644642 cites W1538762819 @default.
- W2011644642 cites W1542149753 @default.
- W2011644642 cites W1719320996 @default.
- W2011644642 cites W1752045965 @default.
- W2011644642 cites W1905836649 @default.
- W2011644642 cites W1963800344 @default.
- W2011644642 cites W1965171504 @default.
- W2011644642 cites W1965757881 @default.
- W2011644642 cites W1966225821 @default.
- W2011644642 cites W1966263947 @default.
- W2011644642 cites W1967033957 @default.
- W2011644642 cites W1967049808 @default.
- W2011644642 cites W1967222268 @default.
- W2011644642 cites W1968255500 @default.
- W2011644642 cites W1969756786 @default.
- W2011644642 cites W1978278335 @default.
- W2011644642 cites W1978984974 @default.
- W2011644642 cites W1979043688 @default.
- W2011644642 cites W1979430908 @default.
- W2011644642 cites W1980866685 @default.
- W2011644642 cites W1980990188 @default.
- W2011644642 cites W1981359573 @default.
- W2011644642 cites W1981478185 @default.
- W2011644642 cites W1981787940 @default.
- W2011644642 cites W1981809048 @default.
- W2011644642 cites W1982786429 @default.
- W2011644642 cites W1984857471 @default.
- W2011644642 cites W1986228673 @default.
- W2011644642 cites W1986940374 @default.
- W2011644642 cites W1988256776 @default.
- W2011644642 cites W1990652035 @default.
- W2011644642 cites W1993328941 @default.
- W2011644642 cites W1993539384 @default.
- W2011644642 cites W1993902386 @default.
- W2011644642 cites W1994686104 @default.
- W2011644642 cites W1994790065 @default.
- W2011644642 cites W1994887713 @default.
- W2011644642 cites W1995718960 @default.
- W2011644642 cites W1995894201 @default.
- W2011644642 cites W1997470313 @default.
- W2011644642 cites W1998570216 @default.
- W2011644642 cites W1999009297 @default.
- W2011644642 cites W2000549941 @default.
- W2011644642 cites W2001525387 @default.
- W2011644642 cites W2002179012 @default.
- W2011644642 cites W2002943691 @default.
- W2011644642 cites W2006087233 @default.
- W2011644642 cites W2006613197 @default.
- W2011644642 cites W2006712783 @default.
- W2011644642 cites W2007104941 @default.
- W2011644642 cites W2007766732 @default.
- W2011644642 cites W2011450045 @default.
- W2011644642 cites W2013353419 @default.
- W2011644642 cites W2013720404 @default.
- W2011644642 cites W2013758266 @default.
- W2011644642 cites W2016397332 @default.
- W2011644642 cites W2017240932 @default.
- W2011644642 cites W2017496728 @default.
- W2011644642 cites W2019123554 @default.
- W2011644642 cites W2019495971 @default.
- W2011644642 cites W2023284474 @default.
- W2011644642 cites W2023894972 @default.
- W2011644642 cites W2024307514 @default.
- W2011644642 cites W2025054356 @default.
- W2011644642 cites W2026638749 @default.
- W2011644642 cites W2026739290 @default.
- W2011644642 cites W2027739413 @default.
- W2011644642 cites W2027802570 @default.
- W2011644642 cites W2028239901 @default.
- W2011644642 cites W2028535131 @default.
- W2011644642 cites W2028937813 @default.
- W2011644642 cites W2029131065 @default.
- W2011644642 cites W2029190737 @default.
- W2011644642 cites W2029219554 @default.
- W2011644642 cites W2029959553 @default.
- W2011644642 cites W2030653181 @default.
- W2011644642 cites W2032058920 @default.
- W2011644642 cites W2032238268 @default.
- W2011644642 cites W2032570745 @default.
- W2011644642 cites W2033345247 @default.
- W2011644642 cites W2033377460 @default.
- W2011644642 cites W2033892864 @default.
- W2011644642 cites W2034224176 @default.
- W2011644642 cites W2034293734 @default.
- W2011644642 cites W2034540804 @default.