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- W2011647066 abstract "Healthcare databases have been used in the past four decades to identify, refine, and evaluate potential safety signals of marketed medical products. Critics have challenged this research because data are from secondary sources and because some published studies have lacked robust methods for exposure and outcome definition and failed to adequately control for biases. We review the history of healthcare databases used in pharmacovigilance for quantifying adverse outcomes associated with therapeutics, methods to improve the quality of this research, and best practices for pharmacoepidemiologic studies. Drug and vaccine safety studies increasingly use information from multiple healthcare databases, with analyses that aim to keep patient-level identifying data with local research custodians. Analytic methods, including high-dimensional exposure propensity scores, use large numbers of variables to reduce confounding and further anonymize patient data. However, due to gaps in and complexities of the available databases, the value of the research depends on experts with knowledge about the clinical context (e.g., how products are prescribed and taken, how outcomes are diagnosed and recorded, what risk factors must be considered), understanding the nuances of individual databases and the clinical practice patterns they represent, and utilizing study designs that minimize bias, particularly confounding by medication indication." @default.
- W2011647066 created "2016-06-24" @default.
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- W2011647066 date "2014-10-12" @default.
- W2011647066 modified "2023-09-28" @default.
- W2011647066 title "Opportunities and Challenges in Using Epidemiologic Methods to Monitor Drug Safety in the Era of Large Automated Health Databases" @default.
- W2011647066 cites W1482401824 @default.
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- W2011647066 cites W1501511408 @default.
- W2011647066 cites W1538065495 @default.
- W2011647066 cites W1569938899 @default.
- W2011647066 cites W1573555636 @default.
- W2011647066 cites W1600992313 @default.
- W2011647066 cites W1841486778 @default.
- W2011647066 cites W1864510953 @default.
- W2011647066 cites W1960737837 @default.
- W2011647066 cites W1967862917 @default.
- W2011647066 cites W1970114601 @default.
- W2011647066 cites W1983311163 @default.
- W2011647066 cites W1984454461 @default.
- W2011647066 cites W1987610593 @default.
- W2011647066 cites W1988399918 @default.
- W2011647066 cites W1999689091 @default.
- W2011647066 cites W2006184595 @default.
- W2011647066 cites W2012514761 @default.
- W2011647066 cites W2014223327 @default.
- W2011647066 cites W2018612904 @default.
- W2011647066 cites W2023149067 @default.
- W2011647066 cites W2031814675 @default.
- W2011647066 cites W2036645664 @default.
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- W2011647066 cites W2078671558 @default.
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- W2011647066 cites W2093371154 @default.
- W2011647066 cites W2094320722 @default.
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- W2011647066 cites W329239 @default.
- W2011647066 cites W4245554566 @default.
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- W2011647066 doi "https://doi.org/10.1007/s40471-014-0026-0" @default.
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