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- W2011650280 abstract "ABSTRACT The findings presented here demonstrate the role of α-catenin in cadherin-based adhesion and mechanotransduction in different mechanical contexts. Bead-twisting measurements in conjunction with imaging, and the use of different cell lines and α-catenin mutants reveal that the acute local mechanical manipulation of cadherin bonds triggers vinculin and actin recruitment to cadherin adhesions in an actin- and α-catenin-dependent manner. The modest effect of α-catenin on the two-dimensional binding affinities of cell surface cadherins further suggests that force-activated adhesion strengthening is due to enhanced cadherin–cytoskeletal interactions rather than to α-catenin-dependent affinity modulation. Complementary investigations of cadherin-based rigidity sensing also suggest that, although α-catenin alters traction force generation, it is not the sole regulator of cell contractility on compliant cadherin-coated substrata." @default.
- W2011650280 created "2016-06-24" @default.
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- W2011650280 date "2014-04-15" @default.
- W2011650280 modified "2023-10-16" @default.
- W2011650280 title "α-Catenin cytomechanics – role in cadherin-dependent adhesion and mechanotransduction" @default.
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- W2011650280 doi "https://doi.org/10.1242/jcs.139014" @default.
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