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• W2011651646 abstract "Glutamate mediated intracellular calcium accumulation and free radical generation are thought to be major mechanisms that contribute to cell death in hypoxic-ischemic brain injury. For this reason, various glutamate receptor antagonists and antioxidants have been investigated for their therapeutic potential. To assess whether l-carnitine, a possible antioxidant, is able to prevent glutamate- and kainic acid (KA)-induced neurotoxicity. Glutamate (10−7 M) and one of its receptor agonists, KA (10−4 M) were administered to cerebellar granular cell cultures that were prepared from 1-day-old Sprague–Dawley rats. The neuroprotective effect of l-carnitine was examined. l-carnitine at doses of 10−6, 10−5, 10−4, 10−3 M was applied to culture flasks. l-carnitine at doses of 10−4 and 10−3 M significantly blocked glutamate-induced neurotoxicity. 10−4 M dose of l-carnitine proved to be more effective than 10−3 M. l-carnitine also blocked KA-induced neurotoxicity only at the dose of 10−4 M. 10−4 M l-carnitine, the most effective dose in both glutamate- and KA-induced neurotoxicity, decreased glutamate-induced neuronal cell death from 36.14±2.95% to 17.59±2.25%; (P<0.001) and KA-induced neuronal cell death from 21.4±0.41 to 13.4±1.38%; (P<0.001). The present study demonstrates that l-carnitine protects against glutamate- and KA-induced neurotoxicity. Protective effect of l-carnitine may result from its antioxidant activity because free radical generation is a common result in either glutamate- or KA-induced neurotoxicity. l-carnitine merits further investigation as a therapeutic option in hypoxic-ischemic brain injury of newborn." @default.
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• W2011651646 date "2005-12-01" @default.
• W2011651646 modified "2023-10-17" @default.
• W2011651646 title "l-carnitine protects against glutamate- and kainic acid-induced neurotoxicity in cerebellar granular cell culture of rats" @default.
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• W2011651646 doi "https://doi.org/10.1016/j.braindev.2005.02.006" @default.
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