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- W2011655967 abstract "Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO. Objectives: The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese. Methods: Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing. Results: The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS. Conclusions: CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese." @default.
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- W2011655967 date "2012-07-01" @default.
- W2011655967 modified "2023-09-24" @default.
- W2011655967 title "CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese" @default.
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- W2011655967 doi "https://doi.org/10.1017/s0317167100014001" @default.
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