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- W2011660168 abstract "Acetylation and deacetylation of chromatin histone protein by histone deacetylase (HDAC) alters chromatin structure and dynamically affects transcriptional regulation. Many lines of evidence indicate that histone hypo-acetylation induces repression of tumour suppressor gene expression. Small molecule inhibitors of HDAC (HDACI) are highly effective in up-regulating tumour suppressor gene expression, reducing tumour growth and inducing programmed cell death in vitro and in cancer patients in phase I and II clinical trials. HDACI-induced growth inhibition and cytotoxicity have been attributed to acetylation of both histone and non-histone proteins. Less studied, but equally important, is the role of HDAC and HDACI on other components of the malignant phenotype: tumour initiation and progression. In this review, we summarise evidence indicating that the in vivo anti-cancer efficacy of HDACIs is at least in part dependent on suppression of cancer cell migration, invasion, metastasis, blood supply, and angiogenesis. As histone hypo-acetylation is involved in the tumourigenesis of various haematological and solid malignancies, the clinical use of HDACIs in patients at high risk of cancer or with precancerous conditions warrants further investigation." @default.
- W2011660168 created "2016-06-24" @default.
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- W2011660168 date "2006-05-01" @default.
- W2011660168 modified "2023-10-06" @default.
- W2011660168 title "Histone deacetylase inhibitors: Multifunctional anticancer agents" @default.
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- W2011660168 cites W1550565578 @default.
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- W2011660168 cites W1969323007 @default.
- W2011660168 cites W1971621147 @default.
- W2011660168 cites W1977931536 @default.
- W2011660168 cites W1981591956 @default.
- W2011660168 cites W1987443571 @default.
- W2011660168 cites W1987932410 @default.
- W2011660168 cites W1989180635 @default.
- W2011660168 cites W1990801507 @default.
- W2011660168 cites W1996487270 @default.
- W2011660168 cites W1997908375 @default.
- W2011660168 cites W2004980848 @default.
- W2011660168 cites W2006881752 @default.
- W2011660168 cites W2008054969 @default.
- W2011660168 cites W2008156174 @default.
- W2011660168 cites W2009781762 @default.
- W2011660168 cites W2009850143 @default.
- W2011660168 cites W2013429896 @default.
- W2011660168 cites W2017767253 @default.
- W2011660168 cites W2021577923 @default.
- W2011660168 cites W2022884475 @default.
- W2011660168 cites W2024425375 @default.
- W2011660168 cites W2025366757 @default.
- W2011660168 cites W2027483071 @default.
- W2011660168 cites W2029644449 @default.
- W2011660168 cites W2031671750 @default.
- W2011660168 cites W2035209422 @default.
- W2011660168 cites W2035323574 @default.
- W2011660168 cites W2041265190 @default.
- W2011660168 cites W2043319086 @default.
- W2011660168 cites W2051026285 @default.
- W2011660168 cites W2053527426 @default.
- W2011660168 cites W2056369410 @default.
- W2011660168 cites W2056656235 @default.
- W2011660168 cites W2064310618 @default.
- W2011660168 cites W2066389184 @default.
- W2011660168 cites W2066756232 @default.
- W2011660168 cites W2069341069 @default.
- W2011660168 cites W2071175338 @default.
- W2011660168 cites W2072259101 @default.
- W2011660168 cites W2075116781 @default.
- W2011660168 cites W2077180950 @default.
- W2011660168 cites W2081635401 @default.
- W2011660168 cites W2082739830 @default.
- W2011660168 cites W2085180690 @default.
- W2011660168 cites W2089692551 @default.
- W2011660168 cites W2090465622 @default.
- W2011660168 cites W2095228162 @default.
- W2011660168 cites W2098536205 @default.
- W2011660168 cites W2100338355 @default.
- W2011660168 cites W2100365251 @default.
- W2011660168 cites W2108230631 @default.
- W2011660168 cites W2120412844 @default.
- W2011660168 cites W2126336008 @default.
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- W2011660168 cites W2140204965 @default.
- W2011660168 cites W2140513457 @default.
- W2011660168 cites W2143591283 @default.
- W2011660168 cites W2147048832 @default.
- W2011660168 cites W2147812298 @default.
- W2011660168 cites W2149386327 @default.
- W2011660168 cites W2152667145 @default.
- W2011660168 cites W2155725346 @default.
- W2011660168 cites W2156712995 @default.
- W2011660168 cites W2157899072 @default.
- W2011660168 cites W2158971210 @default.
- W2011660168 cites W2159113325 @default.
- W2011660168 cites W2166683150 @default.
- W2011660168 cites W2168490864 @default.
- W2011660168 cites W2171074974 @default.
- W2011660168 cites W2171439874 @default.
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- W2011660168 doi "https://doi.org/10.1016/j.ctrv.2005.12.006" @default.
- W2011660168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16516391" @default.
- W2011660168 hasPublicationYear "2006" @default.
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